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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Lysyl oxidase-like 1

Lol, LOXL1, lysyl oxidase-like 1
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AGE, IgE, elastin, HAD, CAN
Papers on Lol
LOXL1 gene analysis in Turkish patients with exfoliation glaucoma.
New
Yagci et al., İzmir, Turkey. In Int Ophthalmol, Feb 2016
UNASSIGNED: The purpose of this study is to evaluate whole lysyl oxidase like 1 (LOXL1) gene by sequence analysis in Turkish patients with exfoliation glaucoma (XFG).
Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse.
New
Shynlova et al., Toronto, Canada. In Reprod Sci, Feb 2016
Collagen XV and tissue inhibitors of MMPs (TIMP1 and TIMP2) as well as genes involved in the biogenesis and maturation of collagen and elastin fibers (LOX, LOXL1-LOXL3, BMP1, and ADAMTS2) were significantly downregulated in POP-HVCs versus control-HVCs (P < .05).
Exfoliation syndrome: assembling the puzzle pieces.
New
Ritch et al., Boston, United States. In Acta Ophthalmol, Jan 2016
Lysyl oxidase-like 1 (LOXL1) variants are unequivocally genetic risk factors for XFS but exactly how these variants contribute to the assembly of exfoliation material (XFM) remains unclear.
Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice.
New
Trackman et al., Boston, United States. In Calcif Tissue Int, Dec 2015
The lysyl oxidase family consists of lysyl oxidase (LOX) and 4 isoforms (LOXL1-4).
Outer membrane lipoprotein biogenesis: Lol is not the end.
Review
New
Silhavy et al., Princeton, United States. In Philos Trans R Soc Lond B Biol Sci, Nov 2015
Outer membrane (OM) lipoproteins take the localization of lipoproteins (Lol) export pathway, which ends with the insertion of the N-terminal lipid moiety into the inner leaflet of the OM.
Association of clusterin (CLU) variants and exfoliation syndrome: An analysis in two Caucasian studies and a meta-analysis.
Review
New
Wiggs et al., Boston, United States. In Exp Eye Res, Oct 2015
LOXL1 variants are highly associated with XFS in most populations; however, the high frequency of risk alleles in normal individuals and the reversal of risk alleles in different ethnic populations suggest that other factors contribute to XFS pathogenesis.
Association of Genetic Variants with Polypoidal Choroidal Vasculopathy: A Systematic Review and Updated Meta-analysis.
Review
New
Chen et al., Hong Kong, Hong Kong. In Ophthalmology, Sep 2015
Another 25 polymorphisms in 13 genes (ARMS2, HTRA1, C2, CFB, ELN, LIPC, LPL, ABCA1, VEGF-A, TLR3, LOXL1, SERPING1, and PEDF) had no significant association.
A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
New
Impact
Khor et al., Singapore, Singapore. In Nat Genet, Apr 2015
Although we also confirmed overwhelming association at the LOXL1 locus, the key SNP marker (LOXL1 rs4886776) demonstrated allelic reversal depending on the ancestry group (Japanese: OR(A allele) = 9.87, P = 2.13 × 10(-217); non-Japanese: OR(A allele) = 0.49, P = 2.35 × 10(-31)).
Update on pseudoexfoliation syndrome pathogenesis and associations with intraocular pressure, glaucoma and systemic diseases.
Review
New
Topouzis et al., London, United Kingdom. In Curr Opin Ophthalmol, Mar 2015
RECENT FINDINGS: In PEX tissues, expression of lysyl oxidase-like 1 (LOXL1) was found to be markedly dysregulated.
Exfoliation syndrome: a disease with an environmental component.
Review
New
Pasquale et al., Boston, United States. In Curr Opin Ophthalmol, Mar 2015
RECENT FINDINGS: In XFS, aberrant microfibril formation emanating from the cell-extracellular matrix interface admixes with other macromolecules and is cross-linked by lysyl oxidase like 1 (LOXL1) activity.
Exfoliative glaucoma: new evidence in the pathogenesis and treatment.
Bertuzzi et al., Monza, Italy. In Prog Brain Res, 2014
Population-based studies have identified mutations on the lysil-oxidase-like 1(LOXL1) gene as a risk factor for PXFS.
Identifying specific proteins involved in eggshell membrane formation using gene expression analysis and bioinformatics.
Gautron et al., Ottawa, Canada. In Bmc Genomics, 2014
Genes encoding collagen-processing enzymes such as lysyl oxidase homologs 1, 2 and 3 (LOXL1, LOXL2 and LOXL3), prolyl 4 hydroxylase subunit α-2 and beta polypeptide (P4HA2 and P4HB) as well as peptidyl-prolyl cis-trans isomerase C (PPIC) were also over-expressed.
Identification of epistatic interactions through genome-wide association studies in sporadic medullary and juvenile papillary thyroid carcinomas.
Borrego et al., Sevilla, Spain. In Bmc Med Genomics, 2014
RP11-648k4.2-DMGDH and RP11-648k4.2-LOXL1).
LOXL1 deficiency in the lamina cribrosa as candidate susceptibility factor for a pseudoexfoliation-specific risk of glaucoma.
GeneRIF
Zenkel et al., Erlangen, Germany. In Ophthalmology, 2012
The findings provide evidence for a pseudoexfoliation-specific elastinopathy of the lamina cribrosa resulting from a primary disturbance in LOXL1 regulation and elastic fiber homeostasis.
Prevalence of high-risk alleles in the LOXL1 gene and its association with pseudoexfoliation syndrome and exfoliation glaucoma in a Latin American population.
GeneRIF
Zenteno et al., Mexico. In Ophthalmic Genet, 2012
This is the first study associating LOXL1 gene polymorphism and pseudoexfoliation syndrome (XFS) is a major risk factor for exfoliation glaucoma in Latin America.
Variations in LOXL1 associated with exfoliation glaucoma do not affect amine oxidase activity.
GeneRIF
Kim et al., Iksan, South Korea. In Mol Vis, 2011
The R141L and G153D variations in the NH2-terminal region of LOXL1 do not affect the amine oxidase activity of LOXL1 associated with exfoliation glaucoma.
Association of lysyl oxidase-like 1 gene polymorphisms with exfoliation syndrome in Koreans.
GeneRIF
Cha et al., Taegu, South Korea. In Mol Vis, 2010
Three LOXL1 single nucleotide polymorphisms are associated with exfoliation syndrome in the Korean population.
Analysis of LOXL1 gene variants in Japanese patients with branch retinal vein occlusion.
GeneRIF
Iwata et al., Izumo, Japan. In Mol Vis, 2010
LOXL1 variants, well established markers for exfoliation syndrome, are not likely genetic markers for branch retinal vein occlusion in Japanese subjects.
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.
Impact
GeneRIF
Stefansson et al., Reykjavík, Iceland. In Science, 2007
The product of LOXL1 catalyzes the formation of elastin fibers found to be a major component of the lesions in exfoliation glaucoma
Elastic fiber homeostasis requires lysyl oxidase-like 1 protein.
Impact
Li et al., Boston, United States. In Nat Genet, 2004
Here we show that mice lacking the protein lysyl oxidase-like 1 (LOXL1) do not deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation.
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