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Von Willebrand factor A domain containing 5A

LOH11CR2A, BCSC-1
human homolg is a putative tumor suppressor gene [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: E-cadherin, PPP2R1B, TSG, p53, hepatocyte growth factor
Papers on LOH11CR2A
Association of BCSC-1 with human esophageal squamous cell carcinoma.
Ju et al., In Neoplasma, 2014
Breast cancer suppressor candidate-1 (BCSC-1) is a newly identified candidate tumor suppressor gene.
Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF.
GeneRIF
Piguet et al., Genève, Switzerland. In Pigment Cell Melanoma Res, 2012
BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype.
Inactivation of CHEK1 and EI24 is associated with the development of invasive cervical carcinoma: clinical and prognostic implications.
Panda et al., Calcutta, India. In Int J Cancer, 2011
region in cervical carcinogenesis, alterations (deletion/methylation/mutation/expression) of the candidate genes LOH11CR2A, EI24 and CHEK1 located in the region were analyzed in 29 cervical intraepithelial neoplasia (CIN), 112 cervical carcinoma (CACX) samples and two CACX cell lines.
Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1-24.2 region in breast carcinoma: clinical and prognostic implications.
GeneRIF
Panda et al., Calcutta, India. In Mol Oncol, 2011
LOH11CR2A, PIG8 and CHEK1 are candidate tumor suppressor genes associated with breast carcinoma and have significant clinical as well as prognostic importance.
[Preparation and characterization of monoclonal antibodies for human BCSC-1 protein].
Liang et al., Weifang, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2010
AIM: To obtain monoclonal antibodies against human BCSC-1 protein for further study of the structure and function of human BCSC-1 protein.
Tumor suppressor function of BCSC-1 in nasopharyngeal carcinoma.
GeneRIF
Zhu et al., Beijing, China. In Cancer Sci, 2009
BCSC-1 suppression might play roles in tumorigenesis of some nasopharyngeal carcinomas
[Experimental BCSC-1 gene therapy on nasopharyngeal carcinoma mediated by adenovirus].
Zhu et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2008
OBJECTIVE: To explore the therapeutic value of BCSC-1 in tumor gene therapy.
Promoter hypermethylation of CCNA1, RARRES1, and HRASLS3 in nasopharyngeal carcinoma.
Sriuranpong et al., Bangkok, Thailand. In Oral Oncol, 2008
Integration of this information suggested eight potential candidate tumor suppressor genes, CCNA1, HRASLS3, RARRES1, CLMN, EML1, TSC22, LOH11CR2A and MCC.
[Inhibition of malignant activities of nasopharyngeal carcinoma cell by ectopic expression of BCSC-1 gene].
Zhu et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2007
OBJECTIVE: To study effects of ectopic expression of BCSC-1 gene on the malignant activi-BCSC-1 cDNA was isolated by RT-PCR ties of human nasopharyngeal carcinoma cell CNE-2L2.
[Ectopic expression of BCSC-1 gene results in enhancement of adhesion and cell cycling blockade of nasopharyngeal carcinoma CNE-2L2 cell].
Zhu et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2007
OBJECTIVE: To study mechanisms of reduction of the malignant activities of human naso-pharyngeal carcinoma cell CNE-2L2 induced by ectopic expression of BCSC-1 gene.
Fine mapping and evaluation of candidate genes for cervical cancer on 11q23.
Rader et al., Saint Louis, United States. In Genes Chromosomes Cancer, 2005
The expression status of USP2, POU2F3, TRIM29, and another proposed TSG that is telomeric to the region (BCSC1) also was examined.
The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.
Croce et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2003
The breakpoint was found within 6 kb of the BCSC-1 candidate tumor suppressor gene located in the LOH11CR2 region whereas additional loss of heterozygosity (LOH) analysis in breast and ovarian tumors, including that of the patient with the t(11;12)(q23;q24), implicated the BCSC-1 locus as the primary target of deletion.
Screening of selected genomic areas potentially involved in thyroid neoplasms.
Rivera-Fillat et al., Barcelona, Spain. In Eur J Cancer, 2001
This result is interesting because the LOH11CR2A gene is localised at this locus.
Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis.
Wingren et al., Linköping, Sweden. In Oncogene, 2001
The coding sequence of PIG8, CHK1, LOH11CR2A and PPP2R1B were screened for mutations using the protein truncation test or single-strand conformational polymorphism, in combination with direct DNA sequencing.
Molecular cloning and characterization of LOH11CR2A, a new gene within a refined minimal region of LOH at 11q23.
Croce et al., Philadelphia, United States. In Genomics, 1998
The gene, called LOH11CR2A, spans an area of approximately 40 kb and is transcribed at a low level in all the tissues in which it has been analyzed.
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