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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Laminin, alpha 3

Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CsF, LAMB3, CAN, HAD, AGE
Papers on LOCS
Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity.
Ito et al., Tsu, Japan. In Int J Oncol, Feb 2016
The level of matrix metallopeptidase 15 (MMP15) mRNA expression was significantly reduced, whereas the level of laminin alpha 3 (LAMA3) and secreted phosphoprotein 1 (SPP1) mRNA expression was significantly increased in Huh7 cells following exposure to C646.
Comparison of clinical cut-points and treatment targets for urine NTX and plasma βCTX-I in osteoporosis.
Vasikaran et al., Perth, Australia. In Clin Biochem, Jan 2016
Urine was analysed routinely and plasma stored at -20C until analysis by enzyme-linked immunosorbent assay (ELISA) (Immunodiagnostic Systems plc), E170 (Roche Diagnostics) and IDS-iSYS (Immunodiagnostic Systems plc) methods.
Performance characteristics of six automated 25-hydroxyvitamin D assays: Mind your 3s and 2s.
Straseski et al., Salt Lake City, United States. In Clin Biochem, Nov 2015
DESIGN AND METHODS: Access2 and UniCel DxI 800 (Beckman Coulter), ARCHITECT i2000SR (Abbott Diagnostics), ADVIA Centaur XP (Siemens), Liaison XL (DiaSorin) and MODULAR E170 (Roche Diagnostics) assays were assessed for accuracy, imprecision, interference, limit of blank, and linearity.
Using immunofluorescence (antigen) mapping in the diagnosis and classification of epidermolysis bullosa: a first report from Iran.
Toossi et al., Tehrān, Iran. In Int J Dermatol, Oct 2015
Genetic molecular studies showed nonsense mutations in the last codon of exon 39 of the laminin α3a (LAMA3) gene (p.Gln57X) and a donor splice site mutation in LAMA3 (IVS57+5G>A) in the first and second family, respectively.
A stop-gain in the laminin, alpha 3 gene causes recessive junctional epidermolysis bullosa in Belgian Blue cattle.
Charlier et al., Liège, Belgium. In Anim Genet, Oct 2015
Combining information from (i) whole-genome sequencing of an affected calf, (ii) transcriptomic data from a panel of tissues and (iii) a list of functionally ranked positional candidates pinpointed a private G to A nucleotide substitution in the LAMA3 gene that creates a premature stop codon (p.Arg2609*) in exon 60, truncating 22% of the corresponding protein.
Corneal status following modified Blumenthal technique of manual small incision cataract surgery (MSICS) compared to phacoemulsification in treatment of grade III or more nuclear sclerosis-cohort study.
Gupta et al., Meerut, India. In Nepal J Ophthalmol, 2015
OBJECTIVE: To evaluate the endothelial cell loss and central corneal thickness in modified Blumenthal technique of MSICS and Phacoemulsification. METHOD: A prospective study in which 50 cases of nuclear sclerosis grade III (LOCS III) or more were randomized in two groups of 25 each.
A Turkish 3-center study evaluation of serum folic acid and vitamin B12 levels in Alzheimer disease.
Avci et al., In Turk J Med Sci, 2014
Vitamin B12 and folic acid levels were measured using Roche E170 and Beckman Coulter DXI 800 immunoassays (chemiluminescence) according to the manufacturers' guideline in all centers.
Genome Wide Methylome Alterations in Lung Cancer.
Spivack et al., New York City, United States. In Plos One, 2014
IPA analyses showed adenocarcinoma-specific promoter DMxDE overlay identified familiar lung cancer nodes [tP53, Akt] as well as less familiar nodes [HBEGF, NQO1, GRK5, VWF, HPGD, CDH5, CTNNAL1, PTPN13, DACH1, SMAD6, LAMA3, AR].
Genomic and molecular aberrations in malignant peripheral nerve sheath tumor and their roles in personalized target therapy.
Du et al., Tianjin, China. In Surg Oncol, 2013
The involved genes in the significant gains aberrations include BIRC5, CCNE2, DAB2, DDX15, EGFR, DAB2, MSH2, CDK6, HGF, ITGB4, KCNK12, LAMA3, LOXL2, MET, and PDGFRA.
Laminin 332 in junctional epidermolysis bullosa.
Bruckner-Tuderman et al., Freiburg, Germany. In Cell Adh Migr, 2013
Mutations in the LAMA3, LAMB3 and LAMC2 genes that encode the three constituent polypeptide chains, α3, β3 and γ2, abrogate or perturb the functions of laminin 332.
Cell surface proteoglycans syndecan-1 and -4 bind overlapping but distinct sites in laminin α3 LG45 protein domain.
Rousselle et al., Lyon, France. In J Biol Chem, 2012
the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4.
Polymerized laminin-332 matrix supports rapid and tight adhesion of keratinocytes, suppressing cell migration.
Miyazaki et al., Yokohama, Japan. In Plos One, 2011
Data show laminin-332 (alpha3ss3gamma2)(Lm332) matrix supported adhesion of keratinocytes much more strongly and stably than purified Lm332.
The clinical relevance of the expression of the ratio of laminin-5 subchains messenger RNA of hepatocellular carcinoma to non-cancerous liver remnant: a prospective study.
Su et al., Taipei, Taiwan. In Hepatogastroenterology, 2011
Expression of a3, ss3 and ?2 cannot predict the prognosis. However, high expression of ?2 mRNA in HCC/non-cancerous liver correlated significantly with the absence of complete encapsulation, which is an important tumor invasiveness factor.
Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers.
Miyazaki et al., Yokohama, Japan. In Cancer Sci, 2011
results suggest that Lm3B11/3B21 may be required for normal mature vessels and interfere with tumor angiogenesis
Methods for the determination of European Union-permitted added natural colours in foods: a review.
Scotter, York, United Kingdom. In Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2011
The nine designated natural colour classes covered are: 1. Curcumin (E100), 2. Riboflavins (E101i-ii), 3. Cochineal (E120), 4. Chlorophylls--including chlorophyllins and copper analogues (E140-141), 5. Caramel Classes I-IV (E150a-d), 6. Carotenoids (E160a-f, E161b, E161g), 7. Beetroot red (E162), 8. Anthocyanins (E163), and 9. Other colours--Vegetable carbon (E153), Calcium carbonate (E170), Titanium dioxide (E171) and Iron oxides and hydroxides (E172).
Type XVII collagen (BP180) can function as a cell-matrix adhesion molecule via binding to laminin 332.
Giudice et al., Milwaukee, United States. In Matrix Biol, 2011
Cell surface COL17 can interact with laminin 332 and, together, participate in the adherence of a cell to the extracellular matrix.
Herlitz junctional epidermolysis bullosa.
Bauer et al., Salzburg, Austria. In Dermatol Clin, 2010
Characterized by generalized, extensive mucocutaneous blistering at birth and early lethality, this devastating condition is most often caused by homozygous null mutations in the genes LAMA3, LAMB3, or LAMC2, each encoding for 1 of the 3 chains of the heterotrimer laminin-332.
Junctional Epidermolysis Bullosa
Lucky et al., Seattle, United States. In Unknown Journal, 2008
The four genes in which mutations are known to cause JEB are LAMB3 (70% of all JEB), COL17A1 (12%), LAMC2 (9%), and LAMA3 (9%).
Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa.
Uitto et al., Philadelphia, United States. In Nat Genet, 1995
Previously, in different JEB phenotypes, mutations have been found in the three genes for the anchoring filament component laminin 5 (LAMA3, LAMB3, and LAMC2) and in the gene for the hemidesmosome-associated integrin beta 4 subunit.
Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes.
Gahr et al., Seattle, United States. In Cell, 1991
In the extracellular matrix of human foreskin keratinocytes (HFKs), epiligrin contains three disulfide-bonded, glycoprotein subunits, E170, E145, and E135, based on molecular size in kilodaltons.
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