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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nucleolar and spindle associated protein 1

LNP, NuSAP, Ulnaless, SAPS3, U-L, PP6R3
NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, AGE, Lac
Papers on LNP
NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity.
Liou et al., Singapore, Singapore. In Sci Rep, Dec 2015
Nucleolar and spindle-associated protein (NuSAP) is a microtubule-associated protein that functions as a microtubule stabiliser.
Briassoulis et al., Vienna, Austria. In Shock, Oct 2015
ATP was correlated with glutamine (p < 0.05), NO2 with citruline (p < 0.03) and glucine (p < 0.05), and NO3 with the metabolic pattern (p < 0.05), CRP (p < 0.02), SAPS3 (p < 0.02) and inversely with pH (p < 0.002).
The communication of physical science uncertainty in European National Adaptation Strategies.
Forster et al., Leeds, United Kingdom. In Clim Change, 2014
The framework is based on but modifies and integrates the notion of the "cascade of uncertainties" and the NUSAP (Numeral Unit Spread Assessment Pedigree) methodology to include the overarching assessment categories of Numerical Value, Spread, Depth and Substantiation.
Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.
Uzawa et al., Chiba, Japan. In Plos One, 2014
BACKGROUND: Nucleolar and spindle-associated protein 1 (NUSAP1) is an important mitotic regulator.
Near-infrared (NIR) up-conversion optogenetics.
Yawo et al., Sendai, Japan. In Sci Rep, 2014
However, there remains room for large improvements in the energy efficiency of the LNP-ChR system.
Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood-brain barrier and glioma cells.
Andresen et al., Denmark. In Int J Nanomedicine, 2014
As a first step in obtaining such a delivery system, this study aims at designing a lipid nanoparticle (LNP) able to efficiently encapsulate siRNA by a combination of titratable cationic lipids.
Incidence and predisposing factors for the development of disturbed glucose metabolism and DIabetes mellitus AFter Intensive Care admission: the DIAFIC study.
De Block et al., Edegem, Belgium. In Crit Care, 2014
A diabetes risk score (FINDRISC) (11.0 versus 9.5, P = 0.001), the SAPS3 score (median of 42 in both groups, P = 0.003) and daily caloric intake during ICU stay (197 vs. 222, P = 0.011) were independently associated with a disturbed glucose metabolism.
Lipid nanoparticles for short interfering RNA delivery.
Cullis et al., Vancouver, Canada. In Adv Genet, 2013
This chapter reviews various challenges and delivery strategies for siRNA, with a particular focus on the development of lipid nanoparticle (LNP) delivery technologies.
Pharmacotherapy of Ebola hemorrhagic fever: a brief review of current status and future perspectives.
Gawlik et al., Kraków, Poland. In Folia Med Cracov, 2013
monoclonal anti EBOV antibodies (ZMapp, MB-003), phosphorodiamidate morpholino oligomers (PMOs), liposomes containing siRNA (LNP-siRNA:TKM-Ebola) and small molecule inhibitors (e.g.
Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape.
Zerial et al., Dresden, Germany. In Nat Biotechnol, 2013
Our results provide insights into LNP-mediated siRNA delivery that can guide development of the next generation of delivery systems for RNAi therapeutics.
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling.
Anderson et al., Cambridge, United States. In Nat Biotechnol, 2013
Niemann-Pick type C1 (NPC1) is shown to be an important regulator of the major recycling pathways of LNP-delivered siRNAs.
Immunotoxicity derived from manipulating leukocytes with lipid-based nanoparticles.
Peer, Tel Aviv-Yafo, Israel. In Adv Drug Deliv Rev, 2012
A common denominator of all these LNP-based platforms is to deliver drugs into specific tissues or cells in a pathological setting with minimal adverse effects on bystander cells.
Safety profile of RNAi nanomedicines.
Gollob et al., Cambridge, United States. In Adv Drug Deliv Rev, 2012
As a case study, the preclinical development of ALN-VSP, the first lipid nanoparticle (LNP)-formulated siRNA therapeutic to be tested in cancer patients, is reviewed to broadly highlight some of the preclinical safety challenges and areas of investigation for "next generation" LNP systems.
ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p.
Ferro-Novick et al., San Diego, United States. In Nat Cell Biol, 2012
Propose that Lnp1p and Sey1p act antagonistically to balance endoplasmic reticular polygonal network formation.
Lipid nanoparticles: state of the art, new preparation methods and challenges in drug delivery.
Gallarate et al., Torino, Italy. In Expert Opin Drug Deliv, 2012
New technologies have been developed for LNP preparation and studies are currently underway in order to obtain the encapsulation of different drugs and to deliver the active molecule to the site of action.
Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis.
Jeng et al., Taipei, Taiwan. In Cell Cycle, 2012
Phosphorylation of NuSAP by Cdk1 is an important mechanism to regulate microtubule dynamics during cell cycle progression.
SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction.
Engelborghs et al., Leuven, Belgium. In Biochem Biophys Res Commun, 2011
Interphase NuSAP-chromatin interaction suggests additional functions for NuSAP, as recently identified for other nuclear spindle assembly factors with a role in gene expression or DNA damage response.
ATM-mediated NuSAP phosphorylation induces mitotic arrest.
Zhang et al., Beijing, China. In Biochem Biophys Res Commun, 2011
this work has uncovered an ATM-dependent checkpoint pathway that prevents mitotic progression by targeting a microtubule-associated protein, NuSAP.
Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation.
Miklos et al., Stanford, United States. In Blood, 2010
NuSAP1 is recognized as an immunogenic antigen in 65% of patients with AML following allogeneic HCT and suggests a tumor antigen role.
A global control region defines a chromosomal regulatory landscape containing the HoxD cluster.
Duboule et al., Genève, Switzerland. In Cell, 2003
We searched for the underlying control sequences upstream from the HoxD cluster and found Lunapark (Lnp), a gene having limb and CNS expression
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