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Lemur tyrosine kinase 2

LMTK2, AATYK2, BREK, brain-enriched kinase, lemur tyrosine kinase 2, KPI-2, Lmr2
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: V1a, Actin, Transferrin, Dab2, iMpact
Papers on LMTK2
Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations.
Borczuk et al., Guangzhou, China. In J Clin Oncol, Aug 2015
RESULTS: In addition to confirming mutations in known cancer-associated genes (TP53, KRAS, PIK3CA, MET, NOTCH, STK11, and RB1), several novel mutations in additional genes, including RASA1, CDH4, CDH7, LAMB4, SCAF1, and LMTK2, were identified and validated.
Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy.
Bradbury et al., North Chicago, United States. In Oncotarget, Jul 2015
We undertook evaluation of the role of Lemur Tyrosine Kinase 2 (LMTK2) in modulating AR activity, as several Genome Wide Association Studies (GWAS) have shown a marked association of LMTK2 activity with the development of prostate cancer.
Signal dependent ER export of lemur tyrosine kinase 2.
Bradbury et al., North Chicago, United States. In Bmc Cell Biol, 2014
BACKGROUND: The membrane anchored kinase, LMTK2, is a serine/threonine kinase predominantly localized to endosomal compartments.
LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells.
Swiatecka-Urban et al., Lisbon, Portugal. In J Biol Chem, 2014
Lemur tyrosine kinase 2 (LMTK2) is a transmembrane protein with serine and threonine but not tyrosine kinase activity.
Myosin VI and its cargo adaptors - linking endocytosis and autophagy.
Buss et al., Cambridge, United Kingdom. In J Cell Sci, 2013
The unique actin motor myosin VI functions at distinct steps during clathrin-mediated endocytosis and the early endocytic pathway - both of which are involved in cargo trafficking and sorting - through interactions with Dab2, GIPC, Tom1 and LMTK2.
[Association of TET2, LMTK2 and FAM84B gene expression with prostate cancer risk in Chinese patients].
Yang et al., Beijing, China. In Zhonghua Zhong Liu Za Zhi, 2013
We compared the differences of allele and genotype frequencies of TET2 (rs7679673, A), LMTK2 (rs6465657, T) and FAM84B (rs12543663, C) gene expressions between the two groups for the allele and genotype frequencies, and explored the relationship between different genotypes and clinical features such as patient age, BMI, Gleason score, PSA level and tumor stage, by Chi-square test in patients with PCa.
Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection.
Bradbury et al., North Chicago, United States. In Am J Physiol Cell Physiol, 2013
Lemur tyrosine kinase 2 (LMTK2) is a novel membrane-anchored kinase reported to be involved in several normal and pathophysiological conditions, including endosomal membrane recycling, prostate cancer, and neurodegeneration.
The transcriptional landscape and mutational profile of lung adenocarcinoma.
Kim et al., Seoul, South Korea. In Genome Res, 2012
Candidates for novel driver mutations were also identified in genes newly implicated in lung adenocarcinoma such as LMTK2, ARID1A, NOTCH2, and SMARCA4.
Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.
Miller et al., London, United Kingdom. In Oncogene, 2012
A recent genome-wide association study identified the gene encoding lemur tyrosine kinase-2 (LMTK2) as a susceptibility gene for prostate cancer.
Cdk5/p35 phosphorylates lemur tyrosine kinase-2 to regulate protein phosphatase-1C phosphorylation and activity.
Miller et al., London, United Kingdom. In J Neurochem, 2012
We describe a new signalling pathway within the nervous system that links cdk5/p35 with phosphatase-1C and which has implications for a number of neuronal functions and neuronal dysfunction
Hemostatic properties of a TFPI antibody.
Petersen, Denmark. In Thromb Res, 2012
Using mAb 2021, we have confirmed the original findings, and further characterized the pro-haemostatic effect of this specific anti-KPI-2 mAb in preclinical studies.
Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis.
Buss et al., Cambridge, United Kingdom. In Oncogene, 2010
Data show that downregulation of myosin VI expression results in a significant reduction in PSA and VEGF secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI-interacting proteins, GIPC and LMTK2 and Dab2.
Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.
Crundwell et al., Exeter, United Kingdom. In Bmc Cancer, 2009
Low LMTK2 expression is associated with the development of prostate cancer.
Identification of new genetic risk factors for prostate cancer.
Eeles et al., United Kingdom. In Asian J Androl, 2009
Three of these loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK2/3.
BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking.
Sutoh et al., Tokyo, Japan. In Genes Cells, 2008
Results show that BREK is critical for the transition of endocytosed membrane vesicles from early endosomes to recycling endosomes and also suggest an involvement of myosin VI in this pathway.
Multiple newly identified loci associated with prostate cancer susceptibility.
Easton et al., United Kingdom. In Nat Genet, 2008
Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.
Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.
Buss et al., Cambridge, United Kingdom. In J Cell Sci, 2008
Myosin VI and LMTK2 are required for the transport of cargo, such as the Transferrin Receptor, from early endosomes to the endocytic recycling compartment.
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