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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lemur tyrosine kinase 3

Lmr3, LMTK3
Top mentioned proteins: AGE, Akt, erbB-2, V1a, CAN
Papers on Lmr3
LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5.
New
Giamas et al., London, United Kingdom. In Cancer Lett, Jan 2016
UNASSIGNED: Lemur tyrosine kinase-3 (LMTK3) plays an important role in cancer progression and is associated with breast, lung, gastric and colorectal cancer.
LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer.
New
Giamas et al., London, United Kingdom. In Cell Rep, Sep 2015
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer, including breast, lung, gastric, and colorectal cancer.
Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer.
New
Lenz et al., Los Angeles, United States. In Pharmacogenomics J, Jun 2015
Those associations remained significant in the multivariable analysis adjusting age, lymph node status, LMTK3 and IGFR variants and HER2 status.
Serum lemur tyrosine kinase-3: a novel biomarker for screening primary non-small cell lung cancer and predicting cancer progression.
Wang et al., Changzhou, China. In Int J Clin Exp Pathol, 2014
LMTK3 protein expression in NSCLC tissues and normal lung tissues was also detected by using immunohistochemical staining.
An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling.
Zhou et al., Harbin, China. In Plos One, 2014
A total of 6 candidate transformation suppressors including INPP4B, Sesn2, TIAR, ACRC, Nup210, LMTK3 were identified.
Transcriptional CCND1 expression as a predictor of poor response to neoadjuvant chemotherapy with trastuzumab in HER2-positive/ER-positive breast cancer.
Nishio et al., Akashi, Japan. In Breast Cancer Res Treat, 2014
In a univariate analysis, a pCR was associated with high mRNA levels of ESR1, PGR, LMTK3, HER2, IGF1R, INPP4B, PDL-1, BCL-2, and CCND1 (P ≤ 0.05).
Endocrine resistance in breast cancer.
Review
Liu et al., In Climacteric, 2014
Several molecular mechanisms have been proposed to be responsible for endocrine resistance in breast cancer, including MIR-451, FGF and FGFR, ADAM12, fibronectin and other soluble stromal factors, PELP1-KDM1, HER2, NOTCH, δEF1, mTOR, AKT/mTOR, Pi3K/AKT, Pi3K/AKT/mTOR, NFκB, LMTK3, IGF1R, cyclin E2, IRF1, Tab2, and SRC-1.
High expression of LMTK3 is an independent factor indicating a poor prognosis in estrogen receptor α-positive breast cancer patients.
Toyama et al., Nagoya, Japan. In Jpn J Clin Oncol, 2014
In this study, we investigated whether messenger RNA expression and polymorphisms of the gene encoding the kinase, LMTK3, are associated with prognosis in breast cancer patients during long-term follow-up.
Prognostic role of lemur tyrosine kinase 3 in postoperative gastric cancer.
Wu et al., Changzhou, China. In Mol Clin Oncol, 2014
Moreover, the expression and polymorphisms of LMTK3 are correlated with the prognosis of breast cancer patients.
The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin β₁.
Giamas et al., Kuala Lumpur, Malaysia. In Sci Signal, 2014
Lemur tyrosine kinase 3 (LMTK3) is associated with cell proliferation and endocrine resistance in breast cancer.
Structural modeling and molecular dynamics studies on the human LMTK3 domain and the mechanism of ATP binding.
Jayanthi et al., Vellore, India. In Mol Biosyst, 2014
The key role of Lemur tyrosine kinase-3 (LMTK3) in regulation of ERα has been identified and it is found to be a novel therapeutic target for breast cancer.
Preoperative serum LMTK3 as a novel biomarker in non-small cell lung cancer.
Yu et al., Shenyang, China. In Tumour Biol, 2014
The lemur tyrosine kinase-3 (LMTK3) has been reported to be involved in tumor progression.
LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking.
Yamamoto et al., Okinawa, Japan. In J Neurosci, 2014
LMTK3 belongs to the LMTK family of protein kinases that are predominantly expressed in the brain.
Lemur tyrosine kinase-3 is a significant prognostic marker for patients with colorectal cancer.
Jiang et al., China. In Int J Clin Exp Pathol, 2013
Lemur tyrosine kinase-3 (LMTK3) belongs to the family of serine-threonine-tyrosine kinases and the aberrant expression of LMTK3 was observed in several human malignancies.
LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome.
GeneRIF
Giamas et al., London, United Kingdom. In Breast Cancer Res Treat, 2012
Higher LMTK3 expression is associated with more aggressive breast cancers.
Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer.
Impact
GeneRIF
Stebbing et al., London, United Kingdom. In Nat Med, 2011
abundance and intronic polymorphism associated with breast cancer survival and response to endocrine therapies
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