gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PDZ and LIM domain 7

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Barr, CAN, V1a, HAD, AGE
Papers using LMP1 antibodies
Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.
Masucci Maria G., In PLoS ONE, 2006
... LMP-1 Ab (CS1-4) antibodies were purchased from DAKO.
The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells.
Stevenson Philip G., In PLoS ONE, 2002
... B95.8-LMP1), NPC (referred to as NPC9-LMP1, CAO-LMP1) or spontaneous lymphoblastoid cell lines (LCL; HS6-LMP1, QC-LMP1, PM-LMP1) using sequence-specific primers and PCR and cloned in frame into the pEGFP-N1 vector (Clontech, Palo Alto, California) ...
De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients
Stein Harald et al., In Virchows Archiv, 2001
... EBV-LMPCS1-4Citrate1:100Dako ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Guan Xin-yuan, In PLoS ONE, 2000
... were performed on an automated stainer (Ventana, Medical Systems, Tucson, AZ, USA), using the antibodies LMP (Clone CS1-4; Cell Marque, Rocklin, USA/California), EBNA2 (Clone ...
Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE
Jin Dong-Yan, In PLoS ONE, 1991
... LMP1 antibody (CS1-4) was purchased from Dako.
Papers on LMP1
PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization.
Liu et al., Chengdu, China. In Oncotarget, Jan 2016
The expression of pig7 resulted in lysosomal membrane permeabilization (LMP) and lysosomal protease (e.g.
Design and synthesis of pyrrolobenzodiazepine-gallic hybrid agents as p53-dependent and -independent apoptogenic signaling in melanoma cells.
Hu et al., Kao-hsiung, Taiwan. In Eur J Med Chem, Jan 2016
On the other hand, mutant p53 RPMI7951 cell death occurred by PBD-GA-mediated mitochondria- and caspase-dependent pathways via lysosomal membrane permeabilization (LMP), but not through p53 signaling.
Glycogen Synthase Kinase-3β and Caspase-2 Mediate Ceramide- and Etoposide-Induced Apoptosis by Regulating the Lysosomal-Mitochondrial Axis.
Chen et al., Taipei, Taiwan. In Plos One, Dec 2015
Treatment with either the ceramide analogue C2-ceramide or the topoisomerase II inhibitor etoposide sequentially induced lysosomal membrane permeabilization (LMP), the reduction of mitochondrial transmembrane potential, and apoptosis.
Consideration of Epstein-Barr Virus-Encoded Noncoding RNAs EBER1 and EBER2 as a Functional Backup of Viral Oncoprotein Latent Membrane Protein 1.
Pimienta et al., Ensenada, Mexico. In Mbio, Dec 2015
Based on published quantitative proteomics data from BJAB cells expressing EBER1 and EBER2, we propose that the EBERs, through their activation of AKT in a B-cell-specific manner, are a functionally redundant backup of latent membrane protein 1 (LMP1)-an essential oncoprotein in EBV-associated malignancies, with a main role in AKT activation.
The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling.
Young et al., Kuala Lumpur, Malaysia. In Sci Rep, Dec 2015
Latent membrane protein 1 (LMP1), the major oncoprotein encoded by EBV, behaves as a constitutively active tumour necrosis factor (TNF) receptor activating a variety of signalling pathways, including the three classic MAPKs (ERK-MAPK, p38 MAPK and JNK/SAPK).
Epstein-Barr virus latency: current and future perspectives.
Robertson et al., München, Germany. In Curr Opin Virol, Oct 2015
We broadly describe the transcription, epigenetic, signaling and super-enhancer functions of the latent nuclear antigens in regulating cellular transcription; the role of LMP2 in utilization of the autophagosome to control cell death, and the association between LMP1, the linear ubiquitin chain assembly complex and TRAF1 which are important for transformation.
[Mechanisms of Epstein-Barr Virus-Mediated Oncogenesis].
Iwakiri, Kōbe, Japan. In Gan To Kagaku Ryoho, Oct 2015
Here, I describe mechanisms of oncogenesis associated with EBV, focusing on functions of EBV latent membrane protein(LMP)and EBV-encoded small RNA (EBER).
EBV noncoding RNA binds nascent RNA to drive host PAX5 to viral DNA.
Steitz et al., New Haven, United States. In Cell, Mar 2015
EBER2 knockdown phenocopies PAX5 depletion in upregulating the expression of LMP2A/B and LMP1, genes nearest the TRs.
Epstein-Barr Virus-Specific Humoral Immune Responses in Health and Disease.
Middeldorp, Amsterdam, Netherlands. In Curr Top Microbiol Immunol, 2014
Humoral immune responses against EBV-encoded tumour antigens LMP1, LMP2 and BARF1 are addressed, which provide novel options for targeted immunotherapy.
The Latent Membrane Protein 1 (LMP1).
Sterz et al., München, Germany. In Curr Top Microbiol Immunol, 2014
Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter, it was recognized as the primary transforming gene product of the virus.
EBNA2 and Its Coactivator EBNA-LP.
Ling et al., München, Germany. In Curr Top Microbiol Immunol, 2014
EBV growth-transformed B-cells express a viral transcriptional program, termed latency III, which is characterized by the coexpression of EBNA2 and EBNA-LP with EBNA1, EBNA3A, -3B, and -3C as well as LMP1, LMP2A, and LMP2B.
Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein-Barr virus latent membrane proteins.
Rooney et al., Houston, United States. In J Clin Oncol, 2014
PURPOSE: Tumor cells from approximately 40% of patients with Hodgkin or non-Hodgkin lymphoma express the type II latency Epstein-Barr virus (EBV) antigens latent membrane protein 1 (LMP1) and LMP2, which represent attractive targets for immunotherapy.
CLP36 and RIL recruit α-actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts.
Sato et al., Hamamatsu, Japan. In Exp Cell Res, 2012
The CLP36 has a redundant role in the formation of stress fibers, but have different effects on stress fiber dynamics in F2408 cells.
Epstein-Barr virus-encoded LMP1 triggers regulation of the ERK-mediated Op18/stathmin signaling pathway in association with cell cycle.
Cao et al., Changsha, China. In Cancer Sci, 2012
findings indicate the existence of a new cell cycle-associated signaling pathway in which LMP1 regulates ERK-mediated Op18/stathmin signaling
Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model.
Rajewsky et al., Boston, United States. In Cell, 2012
We have generated mice expressing the transforming EBV latent membrane protein 1 (LMP1), mimicking a constitutively active CD40 coreceptor, specifically in B cells.
Parent-of-origin effects of FAS and PDLIM1 in attention-deficit/hyperactivity disorder.
Pan et al., Johnson City, United States. In J Psychiatry Neurosci, 2012
PDLIM1 showed moderate parent-of origin effects for some single nucleotide polymorphisms in attention deficit disorder with hyperactivity.
Cutting edge: mouse CD300f (CMRF-35-like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis.
Coligan et al., Rockville, United States. In J Immunol, 2011
We conclude that expression of CD300f conveys additional capacity to recognize phosphatidylserine to myeloid cells.
Alpha-actinin-4 and CLP36 protein deficiencies contribute to podocyte defects in multiple human glomerulopathies.
Wu et al., Pittsburgh, United States. In J Biol Chem, 2011
Alpha-actinin-4 and CLP36 protein deficiencies contribute to podocyte defects in multiple human glomerulopathies
Stat3 controls lysosomal-mediated cell death in vivo.
Watson et al., Cambridge, United Kingdom. In Nat Cell Biol, 2011
A range of stimuli can lead to lysosomal membrane permeabilization (LMP), thus inducing programmed cell death without involvement of the classical apoptotic programme.
Preoperative serum tissue factor levels are an independent prognostic factor in patients with ovarian carcinoma.
Sood et al., Houston, United States. In J Clin Oncol, 2006
Using enzyme-linked immunosorbent assay, we assessed preoperative serum TF levels in 98 women with invasive epithelial ovarian carcinoma, 30 with low malignant potential (LMP) tumors, 16 with benign tumors, and a separate validation group of 39 women with adnexal masses.
share on facebooktweetadd +1mail to friends