gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

LIM domain 7

LMO7, LIM domain only 7, TGFbeta-induced protein
This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: LIM, HAD, Actin, E-cadherin, TGF-beta
Papers on LMO7
Knockdown of Lmo7 inhibits chick myogenesis.
New
Mermelstein et al., Rio de Janeiro, Brazil. In Febs Lett, Feb 2016
UNASSIGNED: The multifunctional protein Lmo7 has been implicated in some aspects of myogenesis in mammals.
A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types.
New
Kato et al., Tokyo, Japan. In Clin Transl Med, Dec 2015
70 proteins including HPX, CTTN, CDH1, EGFR, MUC1 were found as LPIA-type marker candidates, 15 protein candidates for MIA-type marker included CRABP2, LMO7, and NPEP, and 26 protein candidates for AIS-type marker included LTA4H and SOD2.
Lmo7 is dispensable for skeletal muscle and cardiac function.
New
Chen et al., San Diego, United States. In Am J Physiol Cell Physiol, Nov 2015
Recently, a novel protein, Lim-domain only 7 (lmo7) has been reported to play a role in the molecular pathogenesis of EDMD.
LMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy.
New
Holaska et al., Chicago, United States. In Muscle Nerve, Feb 2015
We previously showed that emerin binds directly to the transcription regulator Lmo7 and attenuates its activity to regulate the proper temporal expression of important myogenic differentiation genes.
Comprehensive evaluation of the response of genes to the administration of the antitumor drug S-1 using a low density array.
New
Tangoku et al., Tokushima, Japan. In Int J Oncol, Feb 2015
The expression of the PRSS3, ABCC4, TXN, SHMT1 and CMPK genes was significantly promoted in the orthotopically implanted SCID mouse model of the 4 lung cancer cell lines by the administration of S-1, while the expression of the LMO7 and FOLH1 genes was significantly suppressed.
Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol.
Efferth et al., Mainz, Germany. In Pharmazie, 2013
Among the candidates were genes involved in apoptosis (STAB2, NUMBL), regulation of transcription (CDYL, FOXA2) and diverse other functional groups (INE1, CTRL, MRS2, NEB, LMO7, C9orf3, EHBP1).
The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions.
Wilson et al., Baltimore, United States. In Peerj, 2012
The transcription factor Lmo7 regulates muscle- and heart-relevant genes and is inhibited by binding to emerin, suggesting Lmo7 misregulation contributes to EDMD disease.
Decreased expression of LMO7 and its clinicopathological significance in human lung adenocarcinoma.
Miyoshi et al., In Exp Ther Med, 2011
LIM-domain only protein 7 (LMO7) has been suggested to act as a tumor suppressor for murine lung adenocarcinoma, while its splice variant p100 LMO7/#16 is associated with invasion and metastasis of rat AH130W1 cells.
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
Hakonarson et al., Philadelphia, United States. In Plos Genet, 2011
The most significantly associated SNP (rs539514, P = 5.66×10⁻¹¹) resides in an intronic region of the LMO7 (LIM domain only 7) gene on 13q22.
LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.
GeneRIF
Zhang et al., Cincinnati, United States. In Mol Cell Biol, 2011
show that LMO7 is upregulated in the stroma of invasive breast carcinoma in a manner that correlates with the increased expression of serum response factor target genes
Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes.
GeneRIF
Holaska et al., Chicago, United States. In J Cell Sci, 2011
functional interaction between emerin and Lmo7 is crucial for temporally regulating the expression of key myogenic differentiation genes.
Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis.
Andersen et al., Århus, Denmark. In Bmc Genomics, 2010
RESULTS: By profiling 108 colorectal samples using exon arrays, we identified nine genes (TCF12, OSBPL1A, TRAK1, ANK3, CHEK1, UGP2, LMO7, ACSL5, and SCIN) showing tumor-specific alternative TSS usage in both adenoma and cancer samples relative to normal mucosa.
[Typing of Listeria monocytogenes in import and export foods with PFGE].
Jiao et al., Guangzhou, China. In Wei Sheng Yan Jiu, 2010
Particularly, it was identified that there were three subtype strain groups, each group sharing with the same PFGE pattern, and the similarity reaching 100%: the first group including LMO16 from Canada, LMO18 from America and LMO13 from Denmark, the second group including LMO7 from Denmark and LMO22 from Shunde, and the third group including LMO21 from Guangzhou and LMO8 from Shanxi.
Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation.
McNally et al., Chicago, United States. In Plos One, 2009
We identified clusters of misexpressed genes and examined the nuclear positioning of two such genomic clusters, each harboring genes relevant to striated muscle disease including LMO7 and MBNL2.
Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7.
GeneRIF
Miyoshi et al., Ōsaka, Japan. In Cancer Sci, 2009
Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7 is reported.
Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes.
GeneRIF
Wilson et al., Baltimore, United States. In Hum Mol Genet, 2007
Lmo7 positively regulates many EDMD-relevant genes (including emerin), and is feedback-regulated by binding to emerin.
PDZ and LIM domain-encoding genes: molecular interactions and their role in development.
Review
Bagowski et al., Leiden, Netherlands. In Scientificworldjournal, 2006
In mammals, there are ten genes that encode for both a PDZ domain, and one or several LIM domains: four genes of the ALP subfamily (ALP, Elfin, Mystique, and RIL), three of the Enigma subfamily (Enigma, Enigma Homolog, and ZASP), the two LIM kinases (LIMK1 and LIMK2), and the LIM only protein 7 (LMO7).
Differential expression and molecular characterisation of Lmo7, Myo1e, Sash1, and Mcoln2 genes in Btk-defective B-cells.
GeneRIF
Smith et al., Huddinge, Sweden. In Cell Immunol, 2005
Expressed in both B-cell lines and primary B-lymphocytes.
share on facebooktweetadd +1mail to friends