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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

LIM domain only 4

LMO4, LIM domain only 4
This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: LIM, LIM-only, Ldb1, CAN, LMO2
Papers on LMO4
Lmo4 and other LIM domain only factors are necessary and sufficient for multiple retinal cell type development.
Xiang et al., Guangzhou, China. In Dev Neurobiol, Dec 2015
Here we examined the role of LIM domain only 4 (Lmo4) in retinal development using both gain-of-function and loss-of-function approaches.
MicroRNA-409-3p suppresses colorectal cancer invasion and metastasis partly by targeting GAB1 expression.
Xu et al., Hangzhou, China. In Int J Cancer, Dec 2015
The 3'-UTR binding assays between the candidates and miR-409-3p suggested that only GAB1, NR4A2 and LMO4 were directly regulated by the miRNA.
ϒ-secretase and LARG mediate distinct RGMa activities to control appropriate layer targeting within the optic tectum.
Monnier et al., Lyon, France. In Cell Death Differ, Sep 2015
N-RGMa on the other hand relies on ϒ-secretase cleavage of the intracellular portion of Neogenin to generate an intracellular domain (NeICD) that uses LIM-only protein 4 (LMO4) to block growth.
GWA meta-analysis of personality in Korean cohorts.
Kim et al., Seoul, South Korea. In J Hum Genet, Aug 2015
We investigated the top five single-nucleotide polymorphisms (SNPs) for each trait, and revealed the most highly association with neuroticism and TACC2 (rs1010657, P=8.79 × 10(-7)), extraversion and PTPN12 (rs12537271, P=1.47 × 10(-7)), openness and IMPAD1 (rs16921695, P=5 × 10(-8)), agreeableness and RPS29 (rs8015351, P=1.27 × 10(-6)) and conscientiousness and LMO4 (rs912765, P=2.91 × 10(-6)).
A Selective Role for Lmo4 in Cue-Reward Learning.
Messing et al., Austin, United States. In J Neurosci, Aug 2015
The transcriptional regulator LIM-only 4 (LMO4) is highly expressed in pyramidal neurons of the BLA, where it plays an important role in fear learning.
Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4.
Sabourin et al., Ottawa, Canada. In Biochim Biophys Acta, Jul 2015
These adapter proteins have been demonstrated to interact with LMO4 in the organization of transcriptional complexes.
Preliminary screening of differentially expressed genes involved in methyl-CpG-binding protein 2 gene-mediated proliferation in human osteosarcoma cells.
Guo et al., Chongqing, China. In Tumour Biol, Apr 2015
There were five significant differentially expressed genes, including IGFBP4, HOXC8, LMO4, MDK, and CTGF, which correlated with the MeCP2 gene.
Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling.
Chen et al., Ottawa, Canada. In Neuron, Apr 2015
Mice lacking LMO4, an endogenous inhibitor of the tyrosine phosphatase PTP1B, display reduced mGluR5 phosphorylation, eCB signaling, and profound anxiety that is reversed by genetic or pharmacological suppression of amygdalar PTP1B.
The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.
Asselin-Labat et al., Australia. In Respir Res, 2014
Here we studied the role of the transcriptional regulator Lmo4 during lung development, in the regulation of adult lung epithelial cell proliferation following lung damage and in the context of oncogenic transformation.
The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.
Andersen et al., Irvine, United States. In Plos Genet, 2014
Clim2, in a complex with LMO4, supports mammary stem cells by directly targeting the Fgfr2 promoter in basal cells to increase its expression.
LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.
Geng et al., Shijiazhuang, China. In Mol Biol Rep, 2014
To date, four LIM-domain-only (LMO) proteins (LMO1-LMO4) have been identified.
The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.
Matthews et al., Sydney, Australia. In Plos One, 2013
LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer.
LMO4 inhibits p53-mediated proliferative inhibition of breast cancer cells through interacting p53.
Shan et al., Shijiazhuang, China. In Life Sci, 2012
LMO4 is a direct target of p53 and inhibits p53-mediated proliferative inhibition of breast cancer cells through interacting p53
LIM domain only 4 (LMO4) regulates calcium-induced calcium release and synaptic plasticity in the hippocampus.
Chen et al., Ottawa, Canada. In J Neurosci, 2012
This study demonitratd that LMO4 as a key regulator of calcium-induced calcium release in central neurons, providing a mechanism for LMO4 to modulate a wide range of neuronal functions and behavior.
Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism.
Chen et al., Ottawa, Canada. In Cell Mol Life Sci, 2012
LMO4 is expressed in the ventromedial hypothalamic nuclei but not in the arcurate nucleus, and consistent with their predominant effects in regulating fate metabolism/energy expenditure and feeding.
Lmo4 in the basolateral complex of the amygdala modulates fear learning.
Heberlein et al., United States. In Plos One, 2011
a selective role for LMO4 in the basolateral complex in modulating learned but not unlearned fear
Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward.
Heberlein et al., San Francisco, United States. In J Neurosci, 2011
LMO4 and estrogen receptor alpha are associated with the Alk promoter by chromatin immunoprecipitation and Alk is an estrogen-responsive gene in the striatum.
Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
Maris et al., Philadelphia, United States. In Nature, 2011
LMO1 encodes a cysteine-rich transcriptional regulator, and its paralogues (LMO2, LMO3 and LMO4) have each been previously implicated in cancer.
[Involvement of LMO4 in tumorigenesis associated epithelial-mesenchymal transition].
Deng et al., Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, 2011
LMO4 is a novel member of the LIM-only (LMO) subfamily of LIM domain-containing transcription factors, so named because they are composed almost entirely of two tandem LIM domains.
Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.
Walsh et al., Boston, United States. In Science, 2005
LMO4 is consistently more highly expressed in the embryonic right perisylvian cerebral cortex than in the left
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