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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

LIM domain only 2

LMO2, RBTN2
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008] (from NCBI)
Top mentioned proteins: CK7, LIM, CAN, GATA-1, LIM-only
Papers on LMO2
The LMO2 oncogene regulates DNA replication in hematopoietic cells.
New
Hoang et al., Toulouse, France. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: Oncogenic transcription factors are commonly activated in acute leukemias and subvert normal gene expression networks to reprogram hematopoietic progenitors into preleukemic stem cells, as exemplified by LIM-only 2 (LMO2) in T-cell acute lymphoblastic leukemia (T-ALL).
Identification of potential therapeutic targets for lung cancer by bioinformatics analysis.
New
Qiao et al., Liaocheng, China. In Mol Med Report, Jan 2016
The TF regulatory network indicated that TFs of FOSB and LMO2 had a key role.
FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2.
New
Coffer et al., Utrecht, Netherlands. In Oncogene, Jan 2016
UNASSIGNED: T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex.
Ectopic expression of Hoxb4a in hemangioblasts promotes hematopoietic development in early embryogenesis of zebrafish.
New
He et al., Guiyang, China. In Clin Exp Pharmacol Physiol, Dec 2015
A transgenic zebrafish line was established with Cre-loxP system that stably overexpressed enhanced green fluorescent protein (EGFP)-tagged Hoxb4a protein under the control of hemangioblast-specific lmo2 promoter.
LMO2 at 25 years: a paradigm of chromosomal translocation proteins.
Review
New
Rabbitts et al., Oxford, United Kingdom. In Open Biol, Jun 2015
LMO2 was first discovered through proximity to frequently occurring chromosomal translocations in T cell acute lymphoblastic leukaemia (T-ALL).
Diffuse large B-cell lymphoma classification system that associates normal B-cell subset phenotypes with prognosis.
New
Impact
Johnsen et al., Odense, Denmark. In J Clin Oncol, May 2015
The centroblast subtype had a complex genotype, whereas the centrocyte subtype had high TP53 mutation and insertion/deletion frequencies and expressed LMO2, CD58, and stromal-1-signature and major histocompatibility complex class II-signature genes, which are known to have a positive impact on prognosis.
Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells.
Slukvin et al., Madison, United States. In J Vis Exp, 2014
The addition of LMO2 to GATA2 and TAL1 combination substantially accelerates differentiation and increases erythroid and megakaryocytic cells production.
Intracellular antibody capture: A molecular biology approach to inhibitors of protein-protein interactions.
Review
Rabbitts et al., Oxford, United Kingdom. In Biochim Biophys Acta, 2014
The method called Intracellular Antibody Capture (IAC) has been used to develop inhibitory anti-RAS and anti-LMO2 single domains that have been used for target validation of these antigens in pre-clinical cancer models and illustrate the efficacy of the IAC approach to generation of drug surrogates.
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency.
Impact
Thrasher et al., London, United Kingdom. In N Engl J Med, 2014
Assessment of insertion sites in peripheral blood from patients in the current trial as compared with those in previous trials revealed significantly less clustering of insertion sites within LMO2, MECOM, and other lymphoid proto-oncogenes in our patients.
LMO2 and BCL6 are associated with improved survival in primary central nervous system lymphoma.
Review
Lossos et al., Miami, United States. In Br J Haematol, 2014
We evaluated 69 cases of PCNSL for the expression of HGAL (also known as GCSAM), LMO2 and BCL6 - genes associated with DLBCL prognosis and pathobiology, and analysed their correlation to survival in 49 PCNSL patients receiving MTX-based therapy.
Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos.
GeneRIF
Inbal et al., Jerusalem, Israel. In Dev Biol, 2012
a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure
Detection of LIM domain only 2 (LMO2) in normal human tissues and haematopoietic and non-haematopoietic tumours using a newly developed rabbit monoclonal antibody.
GeneRIF
Marafioti et al., Bologna, Italy. In Histopathology, 2012
The new anti-LMO2 antibody can be applied confidently to routine sections, contributing to the differential diagnosis of several lymphoma subtypes, subtyping of DLBCLs and potential development of innovative therapies.
KDM3B is the H3K9 demethylase involved in transcriptional activation of lmo2 in leukemia.
GeneRIF
Seo et al., Seoul, South Korea. In Mol Cell Biol, 2012
evidence that the H3K9-me1/2 demethylase KDM3B might play a role in leukemogenesis via activation of lmo2 through interdependent actions with the histone acetyltransferase complex containing CBP
Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.
GeneRIF
Lossos et al., Miami, United States. In Blood, 2012
Overexpression of LMO2 in diffuse large B-cell (DLBCL) cell lines results in centrosome amplification.
Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene.
GeneRIF
Yu et al., North Chicago, United States. In Biochem Biophys Res Commun, 2012
This result raises the possibility that oncogenic Lck may activate Lmo2 promoter through direct interaction.
[Progress in improvement of lentiviral vectors' transcriptional read-through].
Review
Zhang et al., Shanghai, China. In Sheng Wu Gong Cheng Xue Bao, 2011
This is due to the vector integrated to the proximity of lmo2 etc proto-oncogene promoters, leading to the activation of onco-gene expression, which raises the concern of the bio-safety of gene therapy vectors.
Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
Impact
Maris et al., Philadelphia, United States. In Nature, 2011
LMO1 encodes a cysteine-rich transcriptional regulator, and its paralogues (LMO2, LMO3 and LMO4) have each been previously implicated in cancer.
Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximab.
Impact
Weisenburger et al., Omaha, United States. In J Clin Oncol, 2011
The use of LMO2 alone showed the lowest concordance with the microarray results.
The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia.
Review
GeneRIF
McCormack et al., Melbourne, Australia. In Clin Cancer Res, 2011
The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia.
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.
Impact
Göttgens et al., Cambridge, United Kingdom. In Cell Stem Cell, 2010
Here, we report the genome-wide binding patterns and combinatorial interactions for ten key regulators of blood stem/progenitor cells (SCL/TAL1, LYL1, LMO2, GATA2, RUNX1, MEIS1, PU.1, ERG, FLI-1, and GFI1B), thus providing the most comprehensive TF data set for any adult stem/progenitor cell type to date.
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