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LIM and cysteine-rich domains 1

LMCD1, LIM and cysteine-rich domains 1
The protein encoded by this gene contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. The presence of LIM domains implies involvement in protein-protein interactions. Expression of this gene has been detected in most tissues, with highest expression in skeletal muscle. Transcript variants utilizing alternative polyA signals have been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LIM, GATA6, POLYMERASE, ACID, Actin
Papers on LMCD1
Genetic association analyses highlight biological pathways underlying mitral valve prolapse.
Leducq Transatlantic MITRAL Network et al., Nantes, France. In Nat Genet, Oct 2015
We highlight LMCD1 (LIM and cysteine-rich domains 1), which encodes a transcription factor and for which morpholino knockdown of the ortholog in zebrafish resulted in atrioventricular valve regurgitation.
Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis.
Kashuba et al., Moscow, Russia. In Dis Markers, 2014
Frequent methylation of the discovered loci was confirmed by bisulfite sequencing on selective sampling of genes: FGF12, GATA2, and LMCD1.
Transcriptome interrogation of human myometrium identifies differentially expressed sense-antisense pairs of protein-coding and long non-coding RNA genes in spontaneous labor at term.
Lipovich et al., Detroit, United States. In J Matern Fetal Neonatal Med, 2014
RESULTS: We identified co-differential expression and correlation at two genomic loci that contain coding-lncRNA gene pairs: SOCS2-AK054607 and LMCD1-NR_024065 in women in spontaneous labor at term.
Tissue-based microarray expression of genes predictive of metastasis in uveal melanoma and differentially expressed in metastatic uveal melanoma.
Elner et al., United States. In J Ophthalmic Vis Res, 2013
PURPOSE: To screen the microarray expression of CDH1, ECM1, EIF1B, FXR1, HTR2B, ID2, LMCD1, LTA4H, MTUS1, RAB31, ROBO1, and SATB1 genes which are predictive of primary uveal melanoma metastasis, and NFKB2, PTPN18, MTSS1, GADD45B, SNCG, HHIP, IL12B, CDK4, RPLP0, RPS17, RPS12 genes that are differentially expressed in metastatic uveal melanoma in normal whole human blood and tissues prone to metastatic involvement by uveal melanoma.
Genomic biomarkers for cardiotoxicity in rats as a sensitive tool in preclinical studies.
Uehara et al., Toyonaka, Japan. In J Appl Toxicol, 2013
Based on their functions, the present study focused on 8 of these 32 genes (Spp1, Fhl1, Timp1, Serpine1, Bcat1, Lmcd1, Rnd1 and Tgfb2).
Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma.
Jou et al., Taipei, Taiwan. In Oncogene, 2012
Together, our results suggest that LMCD1 mutations are potential oncogenic events in HCC metastasis to promote cell migration through the Rac1-signaling pathway.
Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6.
Bruni et al., Florence, Italy. In Plos One, 2010
Quantitative mRNA and protein analysis corroborated the microarray results demonstrating enhanced expression of myogenic marker proteins and regulation of the expression of transcription factor GATA6 and its co-regulator, LMCD1.
Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo.
Frey et al., Heidelberg, Germany. In J Mol Cell Cardiol, 2010
Study show that the novel LIM protein Lmcd1/Dyxin is both sufficient and necessary for cardiomyocyte hypertrophy.
LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling.
Li et al., Wuhan, China. In Hypertension, 2010
LIM and cysteine-rich domains 1 (Lmcd1) is a novel protein that contain 2 LIM domains with regular spacing in the carboxy-terminal region.
Gene expression profiles during hepatic stellate cell activation in culture and in vivo.
Schwabe et al., New York City, United States. In Gastroenterology, 2007
RESULTS: Two thousand seventy-three probe sets were differentially expressed in at least 1 of 3 models of HSC activation, including novel genes that encode proinflammatory and antiapoptotic mediators; transcription factors; cell surface receptors; and cytoskeleton components such as CXCL14, survivin, septin 4, osteopontin, PRX1, LMCD1, GPR91, leiomodin, and anillin.
Differential expression profiling of the blind subterranean mole rat Spalax ehrenbergi superspecies: bioprospecting for hypoxia tolerance.
Band et al., Haifa, Israel. In Physiol Genomics, 2006
Among the most striking results are differential expressions of cardiac ankyrin repeat protein (Carp), activating transcription factor 3 (Atf3), LIM and cysteine-rich domains 1 (Lmcd1), cysteine and glycine-rich protein 2 (Csrp2), and ras homolog gene family, member B (RhoB).
cDNA cloning, sequence analysis of the porcine LIM and cysteine-rich domain 1 gene.
Jiang et al., Wuhan, China. In Acta Biochim Biophys Sin (shanghai), 2005
Using molecular biology combined with in silico cloning, we have cloned the complete coding sequence of pig LIM and the cysteine-rich domain 1 gene (LMCD1) which encodes a 363 amino acid protein.
LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding.
Morrisey et al., Philadelphia, United States. In Mol Cell Biol, 2005
Expression of LMCD1/dyxin is remarkably similar to that of GATA6, with high-level expression observed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium.
A refined comparative map between porcine chromosome 13 and human chromosome 3.
Peelman et al., Merelbeke, Belgium. In Cytogenet Genome Res, 2002
GATA2 (Sw2448; 37 cR; LOD = 8.26), IL5RA (Swr2114; 64 cR; LOD = 3.85), LMCD1 (Sw2450; 61 cR; LOD = 4.73), MME (CP; 50 cR; LOD = 7.75), RYK (Swc22; 12 cR; LOD = 18.62) and SGU003 (Sw1876; 6 cR; LOD = 16.99) by radiation hybrid (RH) mapping to porcine chromosome 13 (SSC13).
Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse.
Burmeister et al., Ann Arbor, United States. In Genomics, 2000
A new human LIM domain gene LMCD1 was identified from RT-PCR products, and partial sequencing of two expressed sequence tag clones flanking the assembled cDNA contig revealed a 1743-bp full-length cDNA with 1098-bp open reading frame.
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