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Baculoviral IAP repeat containing 7

Livin, ML-IAP, KIAP
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, CAN, XIAP, caspase-3, cIAP2
Papers on Livin
The effects of Livin shRNA on the response to cisplatin in HepG2 cells.
New
Zhai et al., Jinan, China. In Oncol Lett, Nov 2015
The present study aimed to generate eukaryotic expression vectors for Livin shRNA and to examine the effects of Livin shRNA on the chemosensitivity of HepG2 hepatocellular carcinoma cells.
Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma.
New
Ding et al., Chengdu, China. In Int J Oncol, Nov 2015
In this study, we attempted to explore the expression of the anti-apoptotic factor Livin in lung adenocarcinoma and its possible relationship to VSV vulnerability.
Effect of siRNA-Livin on drug resistance to chemotherapy in glioma U251 cells and CD133(+) stem cells.
New
Jin et al., Tianjin, China. In Exp Ther Med, Oct 2015
UNASSIGNED: The aim of the present study was to observe the effect of siRNA-Livin on the expression of multidrug resistance-associated protein (MRP) genes in a U251 cell line and U251 stem cells.
Effects of siRNA Livin on EJ human bladder cancer cells treated with mitomycin-C.
New
Zhang et al., Guilin, China. In Oncol Lett, Oct 2015
UNASSIGNED: The aim of this study was to observe the inhibitory and therapeutic effects of small interfering RNA (siRNA) targeting Livin in EJ human bladder cancer cells.
In vitro antitumor immune response induced by dendritic cells transduced with human livin α recombinant adenovirus.
New
Tao et al., Nanchang, China. In Cell Immunol, Sep 2015
Livin is a good candidate for cancer immunotherapy since it is overexpressed in most common human cancers, poorly expressed in most normal adult tissues.
Silencing of Livin inhibits tumorigenesis and metastasis via VEGF and MMPs pathway in lung cancer.
New
Chen et al., Fuzhou, China. In Int J Oncol, Aug 2015
Livin, an inhibitor of apoptosis protein (IAP), is overexpressed in various cancers and decreases tumor sensitivity to chemotherapy and radiotherapy.
Birc7: A Late Fiber Gene of the Crystalline Lens.
New
Bassnett et al., In Invest Ophthalmol Vis Sci, Jul 2015
RESULTS: Expression of Livin, a member of the inhibitor of apoptosis protein (IAP) family encoded by Birc7, was strongly upregulated in deep cortical fiber cells.
Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists.
New
Lacasse et al., Ottawa, Canada. In Int J Dev Biol, Jun 2015
Small molecule antagonists that target specific IAP oncoproteins, primarily cIAP1 and cIAP2, but potentially also XIAP and Livin, modulate distinct immune signal transduction pathways that can lead to an increased sensitivity of tumors cells to cytokine-mediated apoptosis.
EXPRESSION AND CLINICAL SIGNIFICANCE OF APOPTOSIS-ASSOCIATED PROTEINS SURVIVIN AND LIVIN IN CONDYLOMA ACUMINATUM.
New
Zhang et al., Zhengzhou, China. In J Biol Regul Homeost Agents, Apr 2015
The objective of the present study was to explore the expression and significance of survivin and Livin in lesions of Condyloma acuminatum (CA).
shRNA-mediated silencing of sorcin increases drug chemosensitivity in myeloma KM3/DDP and U266/ADM cell lines.
Wang et al., Harbin, China. In Int J Clin Exp Pathol, 2014
Silencing of Sorcin also significantly reduced the mRNA and protein expression levels of MDR1, MRP1, GST-π, Survinvin, Livin, Bcl-2, Cyclin-D1, phospho-Src, C-myc, p21, NF-κB and phospho-AKT, while p53 expression and caspase-3 and caspase-8 activity significantly increased when compared with control group.
Combinatorial cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists.
Review
Lacasse et al., Ottawa, Canada. In Int J Dev Biol, 2014
Small molecule antagonists that target specific IAP oncoproteins, primarily cIAP1 and cIAP2, but potentially also XIAP and Livin, modulate distinct immune signal transduction pathways that can lead to an increased sensitivity of tumors cells to cytokine-mediated apoptosis.
Targeting the inhibitor of Apoptosis Protein BIR3 binding domains.
Review
Jaquith, Vancouver, Canada. In Pharm Pat Anal, 2014
IAP family members include XIAP, cIAP1, cIAP2, NAIP, survivin, Apollon/Bruce, ML-IAP/livin and TIAP.
Research progress on the livin gene and osteosarcomas.
Review
Lu et al., Nanjing, China. In Asian Pac J Cancer Prev, 2013
Livin, as a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family, has specifically high expression in tumor tissues and can inhibit tumor cell apoptosis through multiple ways, which can become a new target for malignant tumor treatment (including osteosarcoma) and might of great significance in the clinical diagnosis of tumors and the screening of anti-tumor agents and carcinoma treatment.
The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives.
Review
Facciorusso, Foggia, Italy. In Curr Diabetes Rev, 2013
Metformin activates 5-adenosine monophosphate-activated protein kinase (AMPK), that has growth inhibition effects on human cancer cell lines via inhibition of its downstream target mammalian target of rapamycin (mTOR), and decreases the expression of Livin, a protein involved in both cell proliferation and survivalexpressed at high level in neoplastic cell.
Targeted silencing of inhibitors of apoptosis proteins with siRNAs: a potential anti-cancer strategy for hepatocellular carcinoma.
Review
Xu et al., Jinan, China. In Asian Pac J Cancer Prev, 2012
There are now 8 recognized members of the IAP-family: NAIP, c-IAP1, c-IAP2, XIAP, Survivin, Bruce, Livin and ILP-2.
BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.
GeneRIF
Huang et al., Glasgow, United Kingdom. In Nat Struct Mol Biol, 2012
Presented is the structure of the human dimeric RING domain from BIRC7 in complex with the E2 UbcH5B covalently linked to Ub.
Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration.
GeneRIF
Rajalingam et al., Frankfurt am Main, Germany. In J Biol Chem, 2012
unknown role for ML-IAP in controlling C-RAF stability and cell migration.
Livin mediates tumor cell invasion in the DU-145 cell line via NF-κB.
GeneRIF
Song et al., Dalian, China. In Oncol Rep, 2012
livin induction of fibronectin regulates tumor cell invasion via nuclear factor kappa-B signaling
Immunity to the melanoma inhibitor of apoptosis protein (ML-IAP; livin) in patients with malignant melanoma.
GeneRIF
Hodi et al., Boston, United States. In Cancer Immunol Immunother, 2012
A broad array of CD4(+) and CD8(+) cellular responses against ML-IAP was observed with novel class I and class II epitopes identified.
siRNA directed against Livin inhibits tumor growth and induces apoptosis in human glioma cells.
GeneRIF
Chen et al., Fuzhou, China. In J Neurooncol, 2012
High Livin is associated with glioma.
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