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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nuclear receptor subfamily 1, group H, member 3

liver X receptor alpha, NR1H3
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: ACID, V1a, PPAR, CAN, PPARgamma
Papers on liver X receptor alpha
Role of PPARα in the Attenuation of Bile Acid-Induced Apoptosis by Omega-3 Long-Chain Polyunsaturated Fatty Acids in Cultured Hepatocytes.
Black et al., Memphis, United States. In Pediatr Res, Feb 2016
Activation of PPARα was evaluated, and expression of PPARα, farnesoid X receptor (FXR), liver X receptor alpha (LXRα), and retinoid X receptor (RXR) mRNA was evaluated by RT-PCR.
Increased mortality and aggravation of heart failure in liver X receptor-α knockout mice after myocardial infarction.
Wang et al., Shanghai, China. In Heart Vessels, Feb 2016
UNASSIGNED: Liver X receptors, LXRα (NR1H3) and LXRβ (NR1H2), are best known as nuclear oxysterol receptors and physiological master regulators of lipid and cholesterol metabolism.
Overexpression of SREBP1 (sterol regulatory element binding protein 1) promotes de novo fatty acid synthesis and triacylglycerol accumulation in goat mammary epithelial cells.
Bionaz et al., China. In J Dairy Sci, Jan 2016
Compared with Ad-GFP cells (control), Ad-nSREBP1 cells had a significant increase in expression of genes related to long-chain fatty acid activation (ACSL1), transport (FABP3), desaturation (SCD1), de novo synthesis of fatty acids (ACSS2, ACLY, IDH1, ACACA, FASN, and ELOVL6), and transcriptional factors (NR1H3 and PPARG).
Soyasaponin Ab inhibits lipopolysaccharide-induced acute lung injury in mice.
Yu et al., Harbin, China. In Int Immunopharmacol, Jan 2016
Furthermore, SA could activate Liver X Receptor Alpha (LXRα) and knockdown of LXRα by RNAi abrogated the anti-inflammatory effects of SA.
Glucagon-like peptide 1 (GLP-1)-based therapy upregulates LXR-ABCA1/ABCG1 cascade in adipocytes.
Abdel-Rahman et al., Galveston, United States. In Biochem Biophys Res Commun, Jan 2016
These transporters are under the transcriptional regulation of liver X receptor alpha (LXR-α).
Liver X receptor alpha and miR-130a-3p regulate the expression of Sphingosine-1-phosphate receptor 2 in human umbilical vein endothelial cells.
Huang et al., China. In Am J Physiol Cell Physiol, Dec 2015
UNASSIGNED: Recent studies have shown that the activation of liver X receptors (LXRs) attenuates the development of atherosclerosis, not only by regulating lipid metabolism but also by suppressing inflammatory signaling.
Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling.
Dzau et al., Durham, United States. In Lab Invest, Dec 2015
UNASSIGNED: Nuclear hormone receptor liver X receptor-alpha (LXRα) has a vital role in cholesterol homeostasis and is reported to have a role in adipose function and obesity although this is controversial.
[New pathophysiological mechanisms of metabolic syndrome: implication of orphan nuclear receptors?].
Lombès et al., Le Kremlin-Bicêtre, France. In Ann Endocrinol (paris), 2012
Several studies have reported beneficial effects of various orphan nuclear receptors, including SHP (Small Heterodimeric Partner, NR0B2) and LXR (Liver X Receptor, NR1H3 and NR1H2), on various components of MetS.
Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.
Morello et al., Italy. In Arterioscler Thromb Vasc Biol, 2012
Pharmacological activation of endothelial LXRs reduces angiogenesis by restraining cholesterol-dependent vascular endothelial growth factor receptor-2 compartmentation and signaling.
Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication.
Sánchez-Campos et al., León, Spain. In Lab Invest, 2012
Studied the effect of HCV NS5A protein, core protein, and viral replication on the intracellular lipid accumulation and the LXRalpha-regulated expression of lipogenic genes.
Lxrα regulates the androgen response in prostate epithelium.
Baron et al., Clermont-Ferrand, France. In Endocrinology, 2012
Lxralpha regulates the androgen response in prostate epithelium
PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway.
Tang et al., Hengyang, China. In Atherosclerosis, 2012
PAPP-A may first down-regulate expression of LXRalpha through the IGF-1/PI3-K/Akt signaling pathway and then decrease expression of ABCA1, ABCG1, SR-B1 and cholesterol efflux in THP-1 macrophage-derived foam cells.
Taurine is a liver X receptor-α ligand and activates transcription of key genes in the reverse cholesterol transport without inducing hepatic lipogenesis.
Lee et al., Seoul, South Korea. In Mol Nutr Food Res, 2012
Data suggest that taurine, a dietary component, is a direct ligand of LXR-alpha and appears to control gene expression of LXR-alpha and it's responsive genes (e.g., ATP-binding cassette transporters) in enterocytes, macrophages, and hepatocytes.
Counter-regulatory role of bile acid activated receptors in immunity and inflammation.
Baldelli et al., Perugia, Italy. In Curr Mol Med, 2010
With a different rank of potency primary and secondary bile acids activates a subset of nuclear receptors including the farnesoid-X-receptor (FXR, NR1H4); the constitutive androstane receptor (CAR, NR1H3), the pregnane-x- receptor (PXR, NR1H2), the vitamin D receptor (VDR, NR1H1).
Liver X receptor in cholesterol metabolism.
Dahlman-Wright et al., Huddinge, Sweden. In J Endocrinol, 2010
LXRalpha and LXRbeta control cholesterol homeostasis.
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.
Russo et al., Milano, Italy. In Nat Med, 2010
production in tumors inhibits functional expression of CCR7 in dendritic cells and dampens antitumor responses
PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1.
Ro et al., Sharjah, United Arab Emirates. In Nucl Recept Signal, 2009
Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) and liver X receptor alpha (LXRalpha) are nuclear receptors that play pivotal roles in macrophage cholesterol homeostasis and inflammation; key biological processes in atherogenesis.
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
Peltonen et al., Los Angeles, United States. In Nat Genet, 2009
We replicate most previously reported associations for these traits and identify nine new associations, several of which highlight genes with metabolic functions: high-density lipoprotein with NR1H3 (LXRA), low-density lipoprotein with AR and FADS1-FADS2, glucose with MTNR1B, and insulin with PANK1.
Fat paradox of steatohepatitis.
Wang et al., Los Angeles, United States. In J Gastroenterol Hepatol, 2008
Although impaired lipid oxidation and export may contribute to this pathological change, enhanced lipogenic regulation is frequently encountered, as characterized by induction of lipogenic or adipogenic transcription factors (peroxisome proliferator-activated receptor [PPAR gamma], liver X receptor alpha[LXR alpha], sterol-regulatory element-binding protein-1c [SREBP-1c]).
International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.
Kliewer et al., Houston, United States. In Pharmacol Rev, 2006
The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor.
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