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Phosphorylase, glycogen, liver

liver glycogen phosphorylase
catalyzes the rate-limiting step of glycogen catabolism [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Glucagon, Insulin, ACID, HAD, CAN
Papers on liver glycogen phosphorylase
Tyrosol, a phenolic compound, ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats.
New
Sheikh et al., India. In Chem Biol Interact, Apr 2015
increase in the activity of liver glycogen phosphorylase were observed in diabetic control rats compared to normal control rats.
Linking glycogen and senescence in cancer cells.
Impact
Schulze et al., London, United Kingdom. In Cell Metab, 2013
(2012) now demonstrate that in hypoxic cancer cells, depletion of liver glycogen phosphorylase causes glycogen accumulation, leading to oxidative stress, induction of senescence, and impaired tumor growth in vivo.
The influence of social status on hepatic glucose metabolism in rainbow trout Oncorhynchus mykiss.
Moon et al., Ottawa, Canada. In Physiol Biochem Zool, 2012
The effects of chronic social stress on hepatic glycogen metabolism were examined in rainbow trout Oncorhynchus mykiss by comparing hepatocyte glucose production, liver glycogen phosphorylase (GP) activity, and liver β-adrenergic receptors in dominant, subordinate, control, fasted, and cortisol-treated fish.
Effect of glucopyranosylidene-spiro-thiohydantoin on glycogen metabolism in liver tissues of streptozotocin-induced and obese diabetic rats.
Gergely et al., Debrecen, Hungary. In Mol Med Report, 2011
Glucopyranosylidene-spiro-thiohydantoin (TH) was found to be one of the most potent glucose derivates, inhibiting the catalytic activity of both muscle and liver glycogen phosphorylase.
Discovery of a series of indan carboxylic acid glycogen phosphorylase inhibitors.
Whittamore et al., Macclesfield, United Kingdom. In Bioorg Med Chem Lett, 2010
The study led to compound 17, which exhibits a good balance of properties including potent inhibition of recombinant human liver glycogen phosphorylase in vitro, a good DMPK profile including excellent bioavailability and low clearance and good in vivo activity in a glucagon challenge model of diabetes in Zucker rats.
Synthesis and pharmacological evaluation of bis-3-(3,4-dichlorophenyl)acrylamide derivatives as glycogen phosphorylase inhibitors.
Tsukamoto et al., Tsukuba, Japan. In Bioorg Med Chem, 2008
During our research using a high-throughput screening system for discovery of a new class of human liver glycogen phosphorylase a (hLGPa) inhibitors, a series of 3-(3,4-dichlorophenyl)acrylamide derivatives were synthesized, and their inhibitory activities toward hLGPa were evaluated.
Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors.
Golden et al., United States. In Bioorg Med Chem Lett, 2008
A series of amino acid anthranilamide derivatives identified from a high-throughput screening campaign as novel, potent, and glucose-sensitive inhibitors of human liver glycogen phosphorylase a are described.
Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
GeneRIF
Kauschke et al., Biberach an der Riß, Germany. In Biochem J, 2008
Data show that inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a.
Tsukamoto et al., Tsukuba, Japan. In Bioorg Med Chem, 2008
A series of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives were prepared and evaluated as inhibitors of human liver glycogen phosphorylase a (hLGPa).
Glutathione-dependent reduction of arsenate by glycogen phosphorylase responsiveness to endogenous and xenobiotic inhibitors.
GeneRIF
Németi et al., Pécs, Hungary. In Toxicol Sci, 2007
Liver-type glycogen phosphorylase can also catalyze reduction of arsenate.
High frequency of missense mutations in glycogen storage disease type VI.
Sharrard et al., Sheffield, United Kingdom. In J Inherit Metab Dis, 2007
Deficiency of liver glycogen phosphorylase in glycogen storage disease (GSD) type VI results in a reduced ability to mobilize glucose from glycogen.
FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase.
Oikonomakos et al., Athens, Greece. In Protein Sci, 2007
FR258900 has been discovered as a novel inhibitor of human liver glycogen phosphorylase a and proved to suppress hepatic glycogen breakdown and reduce plasma glucose concentrations in diabetic mice models.
Synthesis and structure-activity relationships of 3-phenyl-2-propenamides as inhibitors of glycogen phosphorylase a.
Thomson et al., United States. In Bioorg Med Chem Lett, 2006
A series of 3-phenyl-2-propenamides discovered from a high-throughput screening campaign as novel, potent, glucose-sensitive inhibitors of human liver glycogen phosphorylase a is described.
Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
Whitehouse et al., Macclesfield, United Kingdom. In Bioorg Med Chem Lett, 2006
Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described.
Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.
Agius et al., Athens, Greece. In J Med Chem, 2006
Iminosugars DAB (5), isofagomine (9), and several N-substituted derivatives have been identified as potent inhibitors of liver glycogen phosphorylase a (IC(50) = 0.4-1.2
Establishment of correlation between in vitro enzyme binding potency and in vivo pharmacological activity: application to liver glycogen phosphorylase a inhibitors.
Hoover et al., United States. In J Pharmacol Exp Ther, 2006
The present study developed a competition equilibrium dialysis assay using a 96-well dialysis technique to determine the intrinsic Kd for 13 inhibitors of human liver glycogen phosphorylase a (GPa) in the presence of liver homogenate to mimic the physiological environment.
FR258900, a novel glycogen phosphorylase inhibitor isolated from Fungus No. 138354. I. Taxonomy, fermentation, isolation and biological activities.
Hino et al., Tsukuba, Japan. In J Antibiot (tokyo), 2005
FR258900 exhibited a potent inhibitory effect on the activity of liver glycogen phosphorylase, suggesting that this compound may activate hepatic glycogen synthesis via glycogen phosphorylase inhibition.
Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures.
GeneRIF
Sperling et al., Tel Aviv-Yafo, Israel. In Nucleosides Nucleotides Nucleic Acids, 2004
glycogen phosphorylase has a role in 5-phosphoribosyl-1-pyrophosphate generation in liver tissue in the basal (postabsorptive) state
Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis.
GeneRIF
Agius et al., Newcastle upon Tyne, United Kingdom. In Eur J Biochem, 2003
Results suggest that a signalling pathway involving dephosphorylation of phosphorylase a, leading to both activation and translocation of glycogen synthase, is a critical component of the mechanism by which insulin stimulates hepatic glycogen synthesis.
Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase.
GeneRIF
Guinovart et al., Barcelona, Spain. In J Biol Chem, 2003
glycogen phosphorylase is inactivated in liver cells by glucose
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