liver glycogen phosphorylase
Linking glycogen and senescence in cancer cells.
London, United Kingdom. In Cell Metab, 2013
(2012) now demonstrate that in hypoxic cancer cells, depletion of liver glycogen phosphorylase causes glycogen accumulation, leading to oxidative stress, induction of senescence, and impaired tumor growth in vivo.
Discovery of a series of indan carboxylic acid glycogen phosphorylase inhibitors.
Macclesfield, United Kingdom. In Bioorg Med Chem Lett, 2010
The study led to compound 17, which exhibits a good balance of properties including potent inhibition of recombinant human liver glycogen phosphorylase in vitro, a good DMPK profile including excellent bioavailability and low clearance and good in vivo activity in a glucagon challenge model of diabetes in Zucker rats.