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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD300c molecule

LIR, CMRF-35
The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, LC3, MHC, V1a, KIR
Papers on LIR
Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver.
New
Impact
Singh et al., United States. In Cell Metab, Feb 2016
ATGL exhibits LC3-interacting region (LIR) motifs, and mutating a single LIR motif on ATGL displaces ATGL from LD and disrupts lipolysis.
Structure biology of selective autophagy receptors.
New
Song et al., Seoul, South Korea. In Bmb Rep, Jan 2016
They usually have some common domains: LC3-interacting-region (LIR) motif, specific cargo interacting (ubiquitin-dependent or ubiquitin-independent) domain.
Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.
New
Zhang et al., Beijing, China. In Mol Cell, Jan 2016
LGG-1 and LGG-2 interact differentially with autophagy substrates and Atg proteins, many of which carry a LIR motif.
Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130.
New
Tooze et al., London, United Kingdom. In Mol Cell, Jan 2016
GABARAP, unlipidated and lipidated, but not LC3B, GABARAPL1, and GATE-16, specifically promotes ULK kinase activation dependent on the ULK1 LIR motif, elucidating a unique non-hierarchical role for GABARAP in starvation-induced activation of autophagy.
Analysis of memory-like Natural Killer cells in Human Cytomegalovirus-infected children undergoing αβ+T- and B-cell depleted HSCT for hematological malignancies.
New
Della Chiesa et al., Roma, Italy. In Haematologica, Jan 2016
These cells were characterized by high Killer Ig-like Receptors (KIRs) and Leukocyte Inhibitory Receptor 1 (LIR-1) and low Siglec-7, NKG2A and Interleukin-18Rα expression, killed tumor targets and responded to cells expressing HLA-E (a NKG2C ligand).
Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses.
Review
New
Chen et al., Beijing, China. In Biochim Biophys Acta, Oct 2015
One common feature of mitophagy receptors is that they harbor an LC3-interacting region (LIR) that interacts with LC3, thus promoting the sequestration of mitochondria into the isolation membrane.
Host systemic inflammatory response influences outcome in pancreatic cancer.
Review
New
Imrie, Glasgow, United Kingdom. In Pancreatology, Jul 2015
Local inflammatory responses(LIR) are beneficial in PDAC and other cancers.
Post-conditioning through lower limb ischemia-reperfusion can alleviate lung ischemia-reperfusion injury.
Wang et al., Beijing, China. In Int J Clin Exp Med, 2014
METHODS: Bilateral lower limb ischemia was performed in Sprague-Dawley (SD) rats, and then animals were divided into 4 groups: IR-Sham-operated, IR, post conditioned-IR (LIPC) and bilateral lower limb ischemia (LIR).
The LIR motif - crucial for selective autophagy.
Review
Johansen et al., Tromsø, Norway. In J Cell Sci, 2013
At the heart of this selectivity lies the LC3-interacting region (LIR) motif, which ensures the targeting of autophagy receptors to LC3 (or other ATG8 family proteins) anchored in the phagophore membrane.
Interaction domains of p62: a bridge between p62 and selective autophagy.
Review
Wang et al., Hengyang, China. In Dna Cell Biol, 2013
p62 is a multidomain protein that contains different kinds of protein-protein interaction domains, including an N-terminal PB1 domain, a ZZ-type zinc finger domain, a nuclear localization signal (NLS), an export motif (NES), the LC3-interacting region (LIR), the KEAP1-interacting region (KIR), and a C-terminal Ub-associated domain (UBA).
Selective autophagy mediated by autophagic adapter proteins.
Review
Lamark et al., Tromsø, Norway. In Autophagy, 2011
A direct interaction between these autophagic adapters and the autophagosomal marker protein LC3, mediated by a so-called LIR (LC3-interacting region) motif, their inherent ability to polymerize or aggregate as well as their ability to specifically recognize substrates are required for efficient selective autophagy.
Differential expression of CD300a/c on human TH1 and TH17 cells.
GeneRIF
Borrego et al., Bethesda, United States. In Bmc Immunol, 2010
differential expression on human TH1 and TH17 cell memory subsets
Expression and function of CD300 in NK cells.
GeneRIF
Mandelboim et al., Jerusalem, Israel. In J Immunol, 2010
CD300a and CD300c receptors are indistinguishable on the surface of natural killer (NK) cells. The tyrosine residue in the third ITIM motif, Tyr-267-Ala, is the most important residue for execution of the inhibitory signal.
CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands.
GeneRIF
Clark et al., Brisbane, Australia. In Blood, 2008
CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs; CD300a/c RNA and surface expression were downregulated after stimulation of pDCs with TLR7 and TLR9 ligands
Use of genetic profiling in leprosy to discriminate clinical forms of the disease.
Impact
Modlin et al., Los Angeles, United States. In Science, 2003
Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection.
Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor.
Impact
Bjorkman et al., Pasadena, United States. In Nat Immunol, 2003
Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor expressed on monocytes, dendritic cells and lymphocytes, regulates cellular function by binding a broad range of classical and nonclassical major histocompatibility complex (MHC) class I molecules, and the human cytomegalovirus MHC class I homolog UL18.
LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients.
Impact
Carbone et al., Stockholm, Sweden. In Lancet, 2003
LIR-1 (leucocyte immunoglobulin-like receptor-1) is an inhibitory cell surface receptor that has high affinity for an MHC class I homologue (UL18) encoded by human cytomegalovirus.
CMRF-35A, CMRF-35H: potential new CD.
GeneRIF
Hart et al., South Brisbane, Australia. In J Biol Regul Homeost Agents, 2002
CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35A induces cellular activation and effector function [review]
Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2).
Impact
Bjorkman et al., Pasadena, United States. In Immunity, 2000
LIR-1 is an inhibitory receptor that recognizes class I MHC molecules and the human cytomegalovirus class I homolog UL18.
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