The LIR motif - crucial for selective autophagy.
Tromsø, Norway. In J Cell Sci, 2013
At the heart of this selectivity lies the LC3-interacting region (LIR) motif, which ensures the targeting of autophagy receptors to LC3 (or other ATG8 family proteins) anchored in the phagophore membrane.
Interaction domains of p62: a bridge between p62 and selective autophagy.
Hengyang, China. In Dna Cell Biol, 2013
p62 is a multidomain protein that contains different kinds of protein-protein interaction domains, including an N-terminal PB1 domain, a ZZ-type zinc finger domain, a nuclear localization signal (NLS), an export motif (NES), the LC3-interacting region (LIR), the KEAP1-interacting region (KIR), and a C-terminal Ub-associated domain (UBA).
Selective autophagy mediated by autophagic adapter proteins.
Tromsø, Norway. In Autophagy, 2011
A direct interaction between these autophagic adapters and the autophagosomal marker protein LC3, mediated by a so-called LIR (LC3-interacting region) motif, their inherent ability to polymerize or aggregate as well as their ability to specifically recognize substrates are required for efficient selective autophagy.
Expression and function of CD300 in NK cells.
Jerusalem, Israel. In J Immunol, 2010
CD300a and CD300c receptors are indistinguishable on the surface of natural killer (NK) cells. The tyrosine residue in the third ITIM motif, Tyr-267-Ala, is the most important residue for execution of the inhibitory signal.
CMRF-35A, CMRF-35H: potential new CD.
South Brisbane, Australia. In J Biol Regul Homeost Agents, 2002
CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35A induces cellular activation and effector function [review]