The LIR motif - crucial for selective autophagy.
Tromsø, Norway. In J Cell Sci, 2013
At the heart of this selectivity lies the LC3-interacting region (LIR) motif, which ensures the targeting of autophagy receptors to LC3 (or other ATG8 family proteins) anchored in the phagophore membrane.
Interaction domains of p62: a bridge between p62 and selective autophagy.
Hengyang, China. In Dna Cell Biol, 2013
p62 is a multidomain protein that contains different kinds of protein-protein interaction domains, including an N-terminal PB1 domain, a ZZ-type zinc finger domain, a nuclear localization signal (NLS), an export motif (NES), the LC3-interacting region (LIR), the KEAP1-interacting region (KIR), and a C-terminal Ub-associated domain (UBA).
Expression and function of CD300 in NK cells.
Jerusalem, Israel. In J Immunol, 2010
CD300a and CD300c receptors are indistinguishable on the surface of natural killer (NK) cells. The tyrosine residue in the third ITIM motif, Tyr-267-Ala, is the most important residue for execution of the inhibitory signal.
CMRF-35A, CMRF-35H: potential new CD.
South Brisbane, Australia. In J Biol Regul Homeost Agents, 2002
CMRF35A and CMRF35H have roles in immunoglobulin signaling; CMRF35A induces cellular activation and effector function [review]