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Secretoglobin, family 1D, member 2

lipophilin B, LPHB, SCGB1D2
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Mammaglobin, fibrillin-1, EGFR, Uteroglobin, erbB-2
Papers on lipophilin B
Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer.
Monni et al., Helsinki, Finland. In Int J Cancer, Dec 2015
Furthermore, we analyzed expression of a large number of genes located nearby HOXB7 binding sites and found several new direct targets, such as CTNND2 and SCGB1D2.
Gene expression abnormalities in histologically normal breast epithelium from patients with luminal type of breast cancer.
Danko et al., Bratislava, Slovakia. In Mol Biol Rep, May 2015
The main overexpressed genes in HNEpi were KLK5, SCGB1D2, GSN, EGFR and NGFR.
Gene expression profiling of histologically normal breast tissue in females with human epidermal growth factor receptor 2‑positive breast cancer.
Danko et al., Bratislava, Slovakia. In Mol Med Report, Feb 2015
Significant differences in gene expression between BCTis and HNEpi samples were revealed for BCL2L2, CD44, CTSD, EGFR, ERBB2, ITGA6, NGFB, RPL27, SCBG2A1 and SCGB1D2 genes (P<0.05), as well as GSN, KIT, KLK5, SERPINB5 and STC2 genes (P<0.01).
Differential expression of secretoglobins in normal ovary and in ovarian carcinoma--overexpression of mammaglobin-1 is linked to tumor progression.
Borchert et al., Berlin, Germany. In Arch Biochem Biophys, 2014
Secretoglobins (SCGB), such as mammaglobin 1 (MGB1, SCGB2A2), mammaglobin 2 (MGB2, SCGB2A1) and lipophilin B (LIPB, SCGB1D2), have been related to carcinogenesis.
Secretoglobin expression in ovarian carcinoma: lipophilin B gene upregulation as an independent marker of better prognosis.
Santin et al., Brescia, Italy. In J Transl Med, 2012
METHODS: Using quantitative real-time Reverse Transcription PCR we tested 53 ovarian carcinoma and 30 normal ovaries for the expression of 8 genes belonging to the secretoglobin family: mammaglobin A, lipophilin A, lipophilin B, uteroglobin, HIN-1, UGRP-1, RYD5 and IIS.
The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis.
Liu et al., Wuhan, China. In Respir Res, 2010
METHODS: Eight SCGB family members including SCGB3A2 (UGRP1), SCGB1C1 (ligand binding protein RYD5), SCGB1D1 (lipophilin A), SCGB1D2 (lipophilin B), SCGB1D4 (interferon-γ inducible SCGB), SCGB2A1 (mammaglobin 2), SCGB2A2 (mammaglobin 1), and SCGB3A1 (uteroglobin-related protein 2) were studied.
Autoantibodies to tumor-associated antigens in breast carcinoma.
Piura et al., Tel Aviv-Yafo, Israel. In J Oncol, 2009
So far, the following TAAs have been identified to elicit circulating AAbs in breast carcinoma: p53, MUC-1, heat shock proteins (HSP-27, HSP-60, and HSP-90), HER2/neu/c-erb B2, GIPC-1, c-myc, c-myb, cancer-testis antigens (NY-ESO-1), BRCA1, BRCA2, endostatin, lipophilin B, cyclin B1, cyclin D1, fibulin, insulin-like growth factor binding protein 2 (IGFBP-2), topoisomerase II alpha (TOPO2α), and cathepsin D. Measurement of serum AAbs to one specific TAA only is of little value for screening and early diagnosis of breast carcinoma; however, assessment of AAbs to a panel of TAAs may have promising diagnostic potential.
Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation.
Hedman et al., Umeå, Sweden. In Anticancer Res, 2008
Ectopic overexpression of mammaglobin and lipophilin B did not affect the cell proliferation rate of Hs578T breast carcinoma cells in vitro.
Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer.
Duffy et al., Dublin, Ireland. In Int J Cancer, 2007
We conclude that expression of LPB is preferentially but not exclusively restricted to breast tissue.
Significance, detection and markers of disseminated breast cancer cells.
Lacroix, Brussels, Belgium. In Endocr Relat Cancer, 2006
DTC markers are listed and the most currently used of them (KRT19, CEACAM5, TACSTD1, MUC1, EGFR, ERBB2, SCGB2A2, SCGB2A1, SCGB1D2, PIP, SBEM, TFF1, TFF3, ANKRD30A, SPDEF, ESR1, SERPINB5 and GABRP) are discussed, notably on the basis of recent data on breast tumour portraits (luminal epithelial-like, basal/myoepithelial-like and ERBB2).
Evaluation of expression based markers for the detection of breast cancer cells.
Marks et al., Durham, United States. In Breast Cancer Res Treat, 2006
In the current study, we have measured the expression of two markers that emerged from a screen of the Incyte LifeSeq Database and were subsequently shown to be highly restricted to breast epithelium termed BU101 (also called Lipophilin B) and BS106 (small mucin-like protein).
Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L.
Kalbacher et al., Tübingen, Germany. In J Biol Chem, 2006
The protein pattern of healthy human eccrine sweat was investigated and 10 major proteins were detected from which apolipoprotein D, lipophilin B, and cathepsin D (CatD) were identified for the first time in human eccrine sweat.
Expression analysis of mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2) in more than 300 human tumors and matching normal tissues reveals their co-expression in gynecologic malignancies.
Dahl et al., Aachen, Germany. In Bmc Cancer, 2005
BACKGROUND: Mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2), two members of the secretoglobin superfamily, are known to be co-expressed in breast cancer, where their proteins form a covalent complex.
Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding protein.
Kuerer et al., Houston, United States. In Bmc Cancer, 2005
Alpha2HS-glycoprotein [Heavy:Light (H:L) ratio 0.63] was underexpressed in NAF from tumor-bearing breasts, while lipophilin B (H:L ratio 1.42), beta-globin (H:L ratio 1.98), hemopexin (H:L ratio 1.73), and vitamin D-binding protein precursor (H:L ratio 1.82) were overexpressed.
Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas.
Hedman et al., Umeå, Sweden. In Acta Neuropathol, 2005
The present report demonstrates, for the first time, lipophilin B expression in the pituitary and its apparent down-regulation in pituitary adenomas.
Mammaglobin-based strategies for treatment of breast cancer.
Fleming et al., Saint Louis, United States. In Curr Cancer Drug Targets, 2004
It is a member of the secretoglobin gene family and forms a heterodimer with lipophilin B. We have focused on the tissue-specificity of mammaglobin as a potential mechanism for the specific killing of breast cancer cells.
Serum antibodies to lipophilin B detected in late stage breast cancer patients.
Houghton et al., Seattle, United States. In Clin Cancer Res, 2003
Serum antibodies to this protein are detected in late stage breast cancer patients.
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