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Lipocalin 1

lipocalin, tear lipocalin
This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: MMP-9, neutrophil gelatinase-associated lipocalin, CAN, HAD, AGE
Papers on lipocalin
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
New
Girkontaitė et al., Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
RESULTS: Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls.
Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats.
New
Schupp et al., Muscat, Oman. In Cell Physiol Biochem, Feb 2016
RESULTS: Adenine lowered creatinine clearance and elevated the concentrations of urea, creatinine, plasma neutrophil gelatinase-associated lipocalin and urinary N-Acetyl-beta-D-glucosaminidase activity, and increased the concentrations of the uremic toxin indoxyl sulfate, in addition to some inflammatory cytokines.
Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk.
New
De Keulenaer et al., Antwerp, Belgium. In Am J Physiol Endocrinol Metab, Feb 2016
Nephropathy was characterized by abnormalities including hyperfiltration, albuminuria, increased urinary neutrophil gelatinase-associated lipocalin, upregulation of renal fibrotic markers and glomerulosclerosis.
Differences in GFR and Tissue Oxygenation, and Interactions between Stenotic and Contralateral Kidneys in Unilateral Atherosclerotic Renovascular Disease.
New
Textor et al., Rochester, United States. In Clin J Am Soc Nephrol, Feb 2016
Tissue oxygenation (using R(2)* as a measure of deoxyhemoglobin) was determined by blood oxygen level-dependent magnetic resonance imaging at 3 T. Renal vein neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1), and plasma renin activity were measured.
Plasma neutrophil gelatinase-associated lipocalin as a marker for the prediction of worsening renal function in children hospitalized for acute heart failure.
New
Khalifa et al., Az Zaqāzīq, Egypt. In Saudi J Kidney Dis Transpl, Jan 2016
Neutrophil gelatinase-associated lipocalin (NGAL) serves as an early marker for acute renal tubular injury.
Laboratory Animal Allergy in the Modern Era.
Review
New
Jones, London, United Kingdom. In Curr Allergy Asthma Rep, Dec 2015
Recent evidence suggests that members of lipocalin allergens, such as Mus m 1, may act as immunomodulatory proteins, triggering innate immune receptors through toll-like receptors and promoting airway laboratory animal allergy.
Biomarkers of drug-induced acute kidney injury in the adult.
Review
New
Endre et al., Brisbane, Australia. In Expert Opin Drug Metab Toxicol, Nov 2015
Novel biomarkers, accepted for early detection of drug-induced AKI (kidney injury molecule-1, neutrophil gelatinase-associated lipocalin and N-acetyl-β-d-glucosaminidase), may be useful additions in panels of biomarkers.
Structural similarities of human & mammalian lipocalins, and their function in innate immunity and allergy.
Review
New
Roth-Walter et al., Madrid, Spain. In Allergy, Nov 2015
The amino acid identities, as well as their structures by superposition modeling were compared among human lipocalins, hLCN1 and hLCN2, and most important animal lipocalin allergens, such as Can f 2 and Can f 4 from dog, Fel d 4 from cats, Bos d 5 from cow's milk, Equ c 1 from horses and Mus m 1 from mice, all of them representing major allergens.
Acute Kidney Injury in Patients with Cirrhosis.
Review
New
Singal et al., Birmingham, United States. In J Clin Transl Hepatol, Oct 2015
In this regard, novel serum and/or urinary biomarkers such as neutrophil gelatinase-associated lipocalin, interleukins-6 and 18, kidney injury molecule-1, fatty acid binding protein, and endothelin-1 are emerging with a potential for accurately differentiating common causes of AKI.
Practical considerations to drug dosing in children with acute kidney injury.
Review
New
Sharbaf et al., Chicago, United States. In J Clin Pharmacol, Oct 2015
Serum creatinine and urine output along with volume status should be utilized to guide drug dosing when urinary biomarkers including kidney injury molecule 1, interleukin-18 or neutrophil gelatinase-associated lipocalin are not readily available.
STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.
New
Impact
Tsuda et al., Fukuoka, Japan. In Nat Med, Aug 2015
Moreover, we identified lipocalin-2 (LCN2) as an astrocytic STAT3-dependent upregulated factor that was crucial for chronic itch, and we demonstrated that intrathecal administration of LCN2 to normal mice increased spinal GRP-evoked scratching.
The menagerie of human lipocalins: a natural protein scaffold for molecular recognition of physiological compounds.
Review
New
Impact
Skerra et al., Freising, Germany. In Acc Chem Res, May 2015
Depending on the individual structure of a lipocalin, and especially on the lengths and amino acid sequences of its four loops, this pocket can accommodate chemical ligands of various sizes and shapes, including lipids, steroids, and other chemical hormones as well as secondary metabolites such as vitamins, cofactors, or odorants.
The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria.
Impact
Raffatellu et al., Irvine, United States. In Immunity, 2014
IL-22 induced the expression of antimicrobial proteins, including lipocalin-2 and calprotectin, which sequester essential metal ions from microbes.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Impact
Murakami et al., Tokyo, Japan. In Nat Immunol, 2013
PLA2G3 secreted from mast cells is coupled with fibroblastic lipocalin-type PGD2 synthase (L-PGDS) to provide PGD2, which facilitates mast-cell maturation via PGD2 receptor DP1.
Tear lipocalin: structure and function.
Review
GeneRIF
Dartt, Boston, United States. In Ocul Surf, 2011
Tear lipocalin (TLC) is a major protein in tears and has a large ligand-binding cavity that allows the lipocalin to bind an extensive and diverse set of lipophilic molecules.
Lipocalin-1: a potential marker for noninvasive aneuploidy screening.
GeneRIF
Katz-Jaffe et al., United States. In Fertil Steril, 2011
Study has identified the first protein, lipocalin-1, in the secretome of human blastocysts that is associated with chromosome aneuploidy.
The conserved disulfide bond of human tear lipocalin modulates conformation and lipid binding in a ligand selective manner.
GeneRIF
Glasgow et al., Los Angeles, United States. In Biochim Biophys Acta, 2011
The conserved disulfide bond of human tear lipocalin modulates conformation and lipid binding in a ligand selective manner.(
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
Impact
Jain et al., Boston, United States. In J Clin Oncol, 2010
Changes in plasma placental growth factor, basic fibroblast growth factor, matrix metalloproteinase (MMP) -2, soluble VEGF receptor 1, stromal cell-derived factor-1alpha, and soluble Tek/Tie2 receptor and in urinary MMP-9/neutrophil gelatinase-associated lipocalin activity after cediranib were associated with radiographic response or survival.
A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity.
GeneRIF
Skerra et al., Freising, Germany. In Acta Crystallogr D Biol Crystallogr, 2009
Tear lipocalin with the bound artificial ligand 1,4-butanediol has been crystallized in space group P2(1) with four protein molecules in the asymmetric unit and its X-ray structure has been solved at 2.6 A resolution.
Intracavitary ligand distribution in tear lipocalin by site-directed tryptophan fluorescence.
GeneRIF
Glasgow et al., Los Angeles, United States. In Biochemistry, 2009
Results suggest that the excited protein states in tear lipocalin are not unique but consist of many substates.
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