PIKKs--the solenoid nest where partners and kinases meet.
Cambridge, United Kingdom. In Curr Opin Struct Biol, 2014
The recent structure of a truncated mTOR in a complex with mLST8 has provided a basic framework for understanding all of the phosphoinositide 3-kinase (PI3K)-related kinases (PIKKs): mTOR, ATM, ATR, SMG-1, TRRAP and DNA-PK.
Effect of hyperglycemia on human monocyte activation.
Rochester, United States. In J Investig Med, 2011
Hyperglycemia (both 10 and 20 mM)-treated monocyte showed up-regulated phosphorylation of p101 and p110gamma subunits of PI-3 kinase in comparison to 5 mM glucose.
Blindsight depends on the lateral geniculate nucleus.
Bethesda, United States. In Nature, 2010
Before LGN inactivation, high-contrast stimuli presented to the lesion-affected visual field (scotoma) produced significant V1-independent fMRI activation in the extrastriate cortical areas V2, V3, V4, V5/middle temporal (MT), fundus of the superior temporal sulcus (FST) and lateral intraparietal area (LIP) and the animals correctly located the stimuli in a detection task.
Tel2 regulates the stability of PI3K-related protein kinases.
New York City, United States. In Cell, 2008
Tel2 deletion also elicited specific depletion of the mammalian target of rapamycin (mTOR), suppressor with morphological effect on genitalia 1 (SMG1), and transformation/transcription domain-associated protein (TRRAP), and curbed mTOR signaling, indicating that Tel2 affects all six mammalian PIKKs.