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Smg-1 homolog, phosphatidylinositol 3-kinase-related kinase

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, LAP, ACID, EBP, HAD
Papers on LIP
Evaluation of bioremediation potentiality of ligninolytic Serratia liquefaciens for detoxification of pulp and paper mill effluent.
Raj et al., Lucknow, India. In J Hazard Mater, Apr 2016
A lignin-degrading bacterial strain capable of decolourising Azure-B dye was identified as lignin peroxidase (LiP) producing strain LD-5.
Introducing Dunaliella LIP promoter containing light-inducible motifs improves transgenic expression in Chlamydomonas reinhardtii.
Jin et al., Seoul, South Korea. In Biotechnol J, Feb 2016
UNASSIGNED: Promoter of the light-inducible protein gene (LIP) of Dunaliella was recently isolated in our laboratory.
Shwachman-Bodian-Diamond syndrome (SBDS) protein deficiency impairs translation re-initiation from C/EBPα and C/EBPβ mRNAs.
Calkhoven et al., Jena, Germany. In Nucleic Acids Res, Feb 2016
We show that SBDS function is specifically required for efficient translation re-initiation into the protein isoforms C/EBPα-p30 and C/EBPβ-LIP, which is controlled by a single cis-regulatory upstream open reading frame (uORF) in the 5' untranslated regions (5' UTRs) of both mRNAs.
Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex.
Llorca et al., Madrid, Spain. In Nucleic Acids Res, Feb 2016
According to prevailing models, NMD begins by the assembly of the SURF (SMG1-UPF1-eRF1-eRF3) complex at the ribosome, followed by UPF1 activation by additional factors such as UPF2 and UPF3.
Iron regulatory proteins and their role in controlling iron metabolism.
Kühn, Lausanne, Switzerland. In Metallomics, Feb 2015
These mechanisms have probably evolved to maintain the cytoplasmic labile iron pool (LIP) at an appropriate level.
C/EBPβ-LAP*/LAP Expression Is Mediated by RSK/eIF4B-Dependent Signalling and Boosted by Increased Protein Stability in Models of Monocytic Differentiation.
Brand et al., Hannover, Germany. In Plos One, 2014
Its small isoform LIP is associated with proliferation at early premonocytic developmental stages and regulated via mTOR-dependent signalling.
PIKKs--the solenoid nest where partners and kinases meet.
Williams et al., Cambridge, United Kingdom. In Curr Opin Struct Biol, 2014
The recent structure of a truncated mTOR in a complex with mLST8 has provided a basic framework for understanding all of the phosphoinositide 3-kinase (PI3K)-related kinases (PIKKs): mTOR, ATM, ATR, SMG-1, TRRAP and DNA-PK.
Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting.
Dames et al., Garching bei München, Germany. In Membranes (basel), 2014
In humans six family members are known to date, namely mammalian/mechanistic target of rapamycin (mTOR), ataxia-telangiectasia mutated (ATM), ataxia- and Rad3-related (ATR), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), suppressor of morphogenesis in genitalia-1 (SMG-1), and transformation/transcription domain-associated protein (TRRAP).
Lymphangioleiomyomatosis: differential diagnosis and optimal management.
Lo et al., Beijing, China. In Ther Clin Risk Manag, 2013
The main differential diagnoses include pulmonary Langerhans' histiocytosis (PLCH), Birt-Hogg-Dubé syndrome (BHD), lymphoid interstitial pneumonia (LIP), and amyloidosis.
Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients.
Laan et al., Tartu, Estonia. In Front Immunol, 2013
Lymphopenia-induced proliferation (LIP) helps to fill the empty space; by favoring auto-reactive T-cells, it also leads to lymphocyte infiltration in the same tissues as in day 3 thymectomized animals.
Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.
Issaeva et al., Stockholm, Sweden. In Clin Cancer Res, 2012
Levels of SMG-1 expression negatively correlated with HPV status in cancer cell lines and tumors.
A novel role for hSMG-1 in stress granule formation.
Lavin et al., Brisbane, Australia. In Mol Cell Biol, 2011
stress granule formation appears more complex than originally envisaged and hSMG-1 plays a central role in this process.
The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.
O'Reilly et al., Rochester, United States. In Cell Cycle, 2011
SMG1 plays independent roles in responding to DNA, RNA damage and a broader role in protection against cellular stress tna other member of the PIKK family.
Effect of hyperglycemia on human monocyte activation.
Basu et al., Rochester, United States. In J Investig Med, 2011
Hyperglycemia (both 10 and 20 mM)-treated monocyte showed up-regulated phosphorylation of p101 and p110gamma subunits of PI-3 kinase in comparison to 5 mM glucose.
[Effect of inhibiting the expression of hSMG-1 on chemosensitivity of human non-small cell lung cancer H1299 cells].
Chen et al., Beijing, China. In Zhonghua Yi Xue Za Zhi, 2011
The inhibition of hSMG-1 significantly enhances the sensitivity of human lung cancer H1299 cells to gemcitabine and cisplatin.
Blindsight depends on the lateral geniculate nucleus.
Leopold et al., Bethesda, United States. In Nature, 2010
Before LGN inactivation, high-contrast stimuli presented to the lesion-affected visual field (scotoma) produced significant V1-independent fMRI activation in the extrastriate cortical areas V2, V3, V4, V5/middle temporal (MT), fundus of the superior temporal sulcus (FST) and lateral intraparietal area (LIP) and the animals correctly located the stimuli in a detection task.
Tel2 regulates the stability of PI3K-related protein kinases.
de Lange et al., New York City, United States. In Cell, 2008
Tel2 deletion also elicited specific depletion of the mammalian target of rapamycin (mTOR), suppressor with morphological effect on genitalia 1 (SMG1), and transformation/transcription domain-associated protein (TRRAP), and curbed mTOR signaling, indicating that Tel2 affects all six mammalian PIKKs.
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells.
Massagué et al., New York City, United States. In Cancer Cell, 2006
The basis for this loss was traced to an excess of the C/EBPbeta inhibitory isoform LIP.
Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development.
Hajnal et al., Zürich, Switzerland. In Science, 2001
The MAP kinase phosphatase LIP-1 mediates this lateral inhibition of the primary fate.
C/EBP activators are required for HIV-1 replication and proviral induction in monocytic cell lines.
Calame et al., New York City, United States. In Immunity, 1996
Ectopic expression of the dominant negative C/EBP protein LIP inhibited HIV-1 mRNA and virus production in activated U1 cells, demonstrating that C/EBP proteins are required for provirus induction.
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