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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Leucine rich repeat and Ig domain containing 1

LINGO-1
Top mentioned proteins: Nogo, p75, CAN, Troy, NgR
Papers on LINGO-1
Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.
New
Bothwell et al., Seattle, United States. In Mol Cell Neurosci, Jan 2016
Another LIG protein, LINGO-1 has been reported to bind and influence signaling of p75 as well as TrkA, TrkB and TrkC.
Genetics of essential tremor.
New
Tan et al., Singapore, Singapore. In Parkinsonism Relat Disord, Jan 2016
Recent discoveries linking LINGO1, FUS and TENM4 to essential tremor have been met with cautious optimism since reproducibility and pathogenicity have been contentious in previously implicated genes.
Experimental and Clinical Advances in Immunotherapy Strategies for Spinal Cord Injury Target on MAIs and Their Receptors.
New
Wang et al., Chongqing, China. In Curr Pharm Des, Jan 2016
Interestingly, these three structurally different inhibitors share two common receptors, Nogo-66 receptor (NgR) and paired immunoglobulin-like receptor B (PirB), and transduce the inhibitory signal into neurons via their complex combinant and co-receptors, such as p75 neurotrophin receptor (p75NTR), Nogo receptor-interacting protein 1 (LINGO-1), and TROY.
Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/progenitor cells into neurons.
New
Yang et al., Guangzhou, China. In Brain Res, Dec 2015
The Notch pathway inhibits the differentiation of neural stem/progenitor cells and Lingo-1 is a strong negative regulator for myelination and axon growth.
Targeted Inhibition of Leucine-Rich Repeat and Immunoglobulin Domain-Containing Protein 1 in Transplanted Neural Stem Cells Promotes Neuronal Differentiation and Functional Recovery in Rats Subjected to Spinal Cord Injury.
New
Yong et al., Guangzhou, China. In Crit Care Med, Nov 2015
Thus, targeted inhibition of LINGO-1 via RNA interference may enhance transplanted neural stem cell survival and neuronal differentiation in vivo.
Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells.
New
Hu et al., Shanghai, China. In Tumour Biol, Oct 2015
The results of the present study demonstrated that PHEN suppressed the proliferation, migration, invasion, and tumorigenesis of glioma cells, induced LINGO-1 expression, and inhibited the TrkB-Akt pathway, which may prove to be the mechanisms underlying the anti-tumor effect of PHEN on glioma cells.
A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders.
Review
New
Fernandez-Enright et al., Wollongong, Australia. In Neurosci Biobehav Rev, Sep 2015
Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of neuron and oligodendrocyte survival, neurite extension, axon regeneration, oligodendrocyte differentiation, axonal myelination and functional recovery; all processes highly implicated in numerous brain-related functions.
LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis mice.
Zhang et al., Nanjing, China. In Sci Rep, 2014
LINGO-1 (LRR and Ig domain containing NOGO receptor interacting protein 1) has been identified as an inhibitor of oligodendrocyte differentiation and myelination.
Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways.
Lopez et al., Córdoba, Argentina. In Cell Death Dis, 2014
NgRs are part of a multimeric receptor complex, which includes p75(NTR), Lingo-1 and gangliosides.
Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface.
Review
Nikolov et al., New York City, United States. In Neurosci Res, 2014
These inhibitors bind and signal through a single receptor/co-receptor complex that comprises of NgR1/LINGO-1 and either p75 or TROY, triggering intracellular downstream signaling that impedes the re-growth of axons.
Strategies for myelin regeneration: lessons learned from development.
Review
Pang et al., Jackson, United States. In Neural Regen Res, 2014
As remyelination shares certain common mechanisms with developmental myelination, knowledge from study of developmental myelination contributes greatly to emerging myelin regeneration therapies, best evidenced as the recently developed human anti-Nogo receptor interacting protein-1 (LINGO-1) monoclonal antibodies to treat MS patients in clinical trials.
Genetics of essential tremor: meta-analysis and review.
Review
Deuschl et al., Kiel, Germany. In Neurology, 2014
Two genome-wide association studies demonstrated association between variants in the LINGO1 gene (leucine-rich repeat and Ig domain containing 1) and the SLC1A2 gene (solute carrier family 1 member 2) and ET, respectively.
Emerging injectable therapies for multiple sclerosis.
Review
Impact
Calabresi et al., Baltimore, United States. In Lancet Neurol, 2013
Animal models suggest that anti-LINGO1 antibody has remyelinating potential, and phase 2 trials of the antibody are underway.
Genetic variation in LINGO-1 (rs9652490) and risk of Parkinson's disease: twelve studies and a meta-analysis.
GeneRIF
Chen et al., Shanghai, China. In Neurosci Lett, 2012
the present meta-analysis does not support the notion that LINGO1 rs9652490 SNP is a major genetic risk factor for parkinson disease.[meta-analysis]
LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions.
GeneRIF
Krauss et al., Cambridge, United States. In J Biol Chem, 2012
LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions
LINGO1 rs9652490 and rs11856808 are not associated with the risk of Parkinson's disease: results of a meta-analysis.
GeneRIF
Jiménez-Jiménez et al., In Parkinsonism Relat Disord, 2012
This study showed that LINGO1 rs9652490 and rs11856808 are not associated with the risk of Parkinson's disease.
Neutralization of LINGO-1 during in vitro differentiation of neural stem cells results in proliferation of immature neurons.
GeneRIF
Erlandsson et al., Uppsala, Sweden. In Plos One, 2011
a novel role for LINGO-1 in neural stem cell differentiation to neurons
Association study between the LINGO1 gene and Parkinson's disease in the Italian population.
GeneRIF
Quattrone et al., Cosenza, Italy. In Parkinsonism Relat Disord, 2011
Single nucleotide polymorphism(SNP)s of LINGO1 play a role in the development of Parkinson's disease in the Italian population.
Variant in the sequence of the LINGO1 gene confers risk of essential tremor.
Impact
GeneRIF
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2009
Variant in the sequence of the LINGO1 gene confers risk of essential tremor.
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
Impact
GeneRIF
Wu et al., Cambridge, United States. In Nat Med, 2007
Lingo1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
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