The biology of A20-binding inhibitors of NF-kappaB activation (ABINs).
In Adv Exp Med Biol, 2013
The family of A20-Binding Inhibitors of NF-kappaB (ABINs) consists of three proteins, ABIN-1, ABIN-2 and ABIN-3, which were originally identified as A20-binding proteins and inhibitors of cytokines and Lipopolysaccharide (LPS) induced NF-kappaB activation.
ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.
Gent, Belgium. In Biochem Pharmacol, 2009
This review defines ABIN-3 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains.