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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lin-28 homolog A

Lin28
Top mentioned proteins: Sox2, Nanog, CAN, c-Myc, KLF4
Papers using Lin28 antibodies
MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells In Vitro and In Vivo by Targeting E2F2 and CCND2.
Supplier
Das Gokul M., In PLoS ONE, 2009
... Lin28 antibodies were obtained from Abcam (San Francisco, CA) ...
Papers on Lin28
Induced pluripotent stem cells with six reprogramming factors from Prairie Vole, which is an animal model for social behaviors.
New
Fukuda et al., In Cell Transplant, Feb 2016
We constructed a polycistronic reprogramming vector, which included six reprograming factors (Oct3/4, Sox2, Klf4, c-myc, Lin28, and Nanog).
Lin28: an emerging important oncogene connecting several aspects of cancer.
Review
New
Xia et al., Wuxi, China. In Tumour Biol, Feb 2016
UNASSIGNED: RNA-binding protein Lin28 was originally found as a heterochronic gene which played a significant role in the development of Caenorhabditis elegans.
Quantitative Profiling Identifies Potential Regulatory Proteins Involved in Developmental from Dauer Stage to L4 Stage in Caenorhabditis elegans.
New
Paik et al., In J Proteome Res, Feb 2016
To identify the specific proteins in which the Muv phenotype is highly suppressed, quantitative proteomic analysis with iTRAQ labeling of samples obtained from worms at L1 + 30 h (for continuous development [CD]) and dauer recovery + 3 h (for post-dauer development [PD]) was carried out to detect changes in protein abundance in the CD and PD states of both N2 and lin-28(n719).
Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.
New
Iwama et al., Chiba, Japan. In Exp Hematol, Feb 2016
Of note, many of the fetal-specific let-7 target genes, including Lin28, appear to be transcriptionally repressed by Ezh2-mediated H3K27me3 in BM HSPCs, and Ezh2 loss results in their ectopic expression, particularly in hematological malignancies that develop in the absence of Ezh2.
Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts.
New
Ko et al., In Biol Chem, Feb 2016
Nanog is a transcription factor involved in the maintenance of embryonic stem cells and is one of the reprogramming factors along with Oct4, Sox2, and Lin28.
Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue.
New
Kim et al., Seoul, South Korea. In Int J Mol Med, Jan 2016
The gene expression profiles of stemness-related genes [octamer-binding transcription factor 4 (OCT4), sex determining region Y-box (SOX)2, MYC, Krüppel-like factor 4 (KLF4), NANOG, LIN28 and REX1] and lineage‑related and differentiation stage-related genes [B4GALNT1 (GM2/GS2 synthase), inhibin, beta A (INHBA), distal-less homeobox 5 (DLX5), runt-related transcription factor 2 (RUNX2), proliferator‑activated receptor gamma (PPARG), CCAAT/enhancer-binding protein alpha (C/EBPA), bone morphogenetic protein 7 (BMP7) and SOX9] were compared using RT-PCR.
Transposon-based reprogramming to induced pluripotency.
Review
New
Kues et al., Hisār, India. In Histol Histopathol, Dec 2015
Commonly, iPS cells are generated by viral transduction of core reprogramming genes, such as Oct4, Sox2, Klf4, c-Myc, Nanog and Lin28.
Generation and periodontal differentiation of human gingival fibroblasts-derived integration-free induced pluripotent stem cells.
Review
New
Luan et al., Beijing, China. In Biochem Biophys Res Commun, Nov 2015
Here, we successfully generated iPSCs from readily accessible human gingival fibroblasts (hGFs) through an integration-free and feeder-free approach via delivery of reprogramming factors of Oct4, Sox2, Klf4, L-myc, Lin28 and TP53 shRNA with episomal plasmid vectors.
LIN28: roles and regulation in development and beyond.
Review
New
Romer-Seibert et al., United States. In Development, Aug 2015
LIN28 is an RNA-binding protein that is best known for its roles in promoting pluripotency via regulation of the microRNA let-7.
A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry.
New
Impact
Nolan et al., Stanford, United States. In Cell Stem Cell, Apr 2015
Ki67(low) cells from this intermediate population reverted to a MEF-like phenotype, but Ki67(high) cells advanced through the M-E-T and then bifurcated into two distinct populations: an ESC-like Nanog(high)Sox2(high)CD54(high) population and a mesendoderm-like Nanog(low)Sox2(low)Lin28(high)CD24(high)PDGFR-α(high) population.
The nucleolus gets the silent treatment.
Impact
Feinberg, Baltimore, United States. In Cell Stem Cell, 2015
(2014) provide insight into how global heterochromatin condensation and LIN28 sequestration in embryonic stem cells are independent mechanisms regulating pluripotency in the oft-overlooked nucleolus.
SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs.
Impact
Lee et al., Taejŏn, South Korea. In Cell Stem Cell, 2015
LIN28-mediated processing of the microRNA (miRNA) let-7 has emerged as a multilevel program that controls self-renewal in embryonic stem cells.
Deconstructing transcriptional heterogeneity in pluripotent stem cells.
Impact
Collins et al., Boston, United States. In Nature, 2015
Notably, either removal of mature microRNAs or pharmacological blockage of signalling pathways drives PSCs into a low-noise ground state characterized by a reconfigured pluripotency network, enhanced self-renewal and a distinct chromatin state, an effect mediated by opposing microRNA families acting on the Myc/Lin28/let-7 axis.
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.
Impact
Jaenisch et al., Jerusalem, Israel. In Cell Stem Cell, 2014
Based on tetraploid complementation, we found that ectopic expression of Sall4, Nanog, Esrrb, and Lin28 (SNEL) in mouse embryonic fibroblasts (MEFs) generated high-quality iPSCs more efficiently than other combinations of factors including OSKM.
Lin28 Mediates Cancer Chemotherapy Resistance via Regulation of miRNA Signaling.
Review
Jiang et al., In Hepatogastroenterology, 2014
Lin28 is a highly conserved RNA-binding protein, it consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs.
Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors.
GeneRIF
Roopra et al., Madison, United States. In Cancer Res, 2012
findings therefore show a critical role for the REST-LIN28A axis in tumor aggression and suggest a causative relationship between REST loss and tumorigenicity in vivo
Lin28 regulates HER2 and promotes malignancy through multiple mechanisms.
GeneRIF
Huang et al., New Haven, United States. In Cell Cycle, 2012
Lin28 stimulates HER2 expression at the posttranscriptional level, and that enforced Lin28 expression promotes cancer cell growth via multiple mechanisms.
Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer.
GeneRIF
Zhang et al., Philadelphia, United States. In J Biol Chem, 2012
Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer.
High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer.
GeneRIF
Doki et al., Suita, Japan. In Br J Cancer, 2012
High expression of Lin28 is associated with poor prognosis and high tumour aggressiveness in oesophageal cancer and these effects are mediated through increased proliferation and invasiveness of oesophageal cancer cells.
miR-125b promotes early germ layer specification through Lin28/let-7d and preferential differentiation of mesoderm in human embryonic stem cells.
GeneRIF
Bernstein et al., San Francisco, United States. In Plos One, 2011
LIN28 is a predicted target of miR-125b in differentiating human embryonic stem cells.
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