GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
LIM domain kinase 1
LIMK1, LIMK
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011] (from
NCBI)
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Papers using
LIMK1
antibodies
A role of LIM kinase 1/cofilin pathway in regulating endocytic trafficking of EGF receptor in human breast cancer cells
Supplier
In Molecular Cancer, 2005
... cells were developed by stable transfection of constitutively active (phosphomimic mutant) LIMK1 gene containing a Flag tag at the 3' end cloned in pRevTRE (Clontech, Mountain View, CA), and ...
Papers on
LIMK1
Correlation between Rho-kinase pathway gene expressions and development and progression of glioblastoma multiforme.
New
Gaziantep, Turkey. In Tumour Biol, 22 Feb 2013
There was a significant relationship between the overexpression of Rho-kinase pathway-related genes LIMK1, CFL1, CFL2, and BCL2 and low expression of MAPK1 gene and the survival of the patients.
[Detection of a Williams Beuren syndrome case by MLPA].
New
Mendoza, Argentina. In Medicina (b Aires), Dec 2012
This technique allowed to detect the deletion of CYLN2, FZD9, STX1A, ELN, LIMK1 and RFC2 genes.
ECM-Dependent HIF Induction Directs Trophoblast Stem Cell Fate via LIMK1-Mediated Cytoskeletal Rearrangement.
New
San Francisco, United States. In Plos One, Dec 2012
HIF-2α ensures TSC cytoskeletal integrity and promotes invasive TGC formation by interacting with c-MYC to induce non-canonical expression of Lim domain kinase 1-an enzyme that regulates microtubule and actin stability, as well as cell invasion.
Alphavbeta3 suppresses the RhoA-LIMK1 pathway in K1735 melanoma.
New
Davis, United States. In J Calif Dent Assoc, Dec 2012
The authors found that expression of alphavbeta3 suppresses activation of RhoA thus inhibiting LIMK1 phosphorylation of cofilin.
[Participation of GDNF, LIMK1 signal pathways and heat shock proteins in processes of Drosophila learning and memory formation].
New
In Zh Evol Biokhim Fiziol, Nov 2012
This bidirectional coupling between presynaptic neurons and their postsynaptic targets involve neurotrophins (NTF), such as glial cell-derived neurotrophic factor (GDNF) that is produced LIM kinase 1 (LIMK1, the key enzyme of actin remodeling).
HIV-1 proteins join the family of LIM kinase partners. New roads open up for HIV-1 treatment.
Review
Siena, Italy. In Drug Discov Today, 2012
LIM kinases (LIMK) exert their functions by recruiting many macromolecular partners that could contribute to modulate LIMK activity in a positive or negative manner.
LIM kinase has a dual role in regulating lamellipodium extension by decelerating the rate of actin retrograde flow and the rate of actin polymerization.
GeneRIF
Sendai, Japan. In J Biol Chem, 2011
LIMK1 has a dual role in regulating lamellipodium extension by decelerating actin retrograde flow and polymerization.
p57(Kip2) and cancer: time for a critical appraisal.
Review
Napoli, Italy. In Mol Cancer Res, 2011
p57(Kip2) also plays a critical role in controlling cytoskeletal organization and cell migration through its interaction with LIMK-1.
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Impact
Glasgow, United Kingdom. In Cancer Cell, 2011
Inhibiting actomyosin contractility by blocking LIMK or myosin ATPase attenuated these responses, as did FAK inhibition.
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
GeneRIF
Manassas, United States. In J Biol Chem, 2011
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population.
GeneRIF
Tokyo, Japan. In J Hum Genet, 2011
evealed a SNP, rs6460071 located on LIMK1 gene (P = 0.00069) to be significantly associated with increased risk of intracranial aneurysm
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells.
GeneRIF
Orlando, United States. In Mol Cancer, 2010
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1 in prostate cancer cells
Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression.
GeneRIF
Aurora, United States. In Mol Cancer, 2010
LIMK1 activity in both the cytoplasmic and nuclear compartments promotes breast cancer progression.
Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension.
Review
Nashville, United States. In Adv Exp Med Biol, 2009
BMPR2 potentially signals through multiple immediate downstream pathways, including Smad, MAPK, LIM domain kinase 1 (LIMK) and dynein, light chain, Tctex-type 1 (TCTEX), v-src sarcoma viral oncogene homolog (SRC), and nuclear factor kappa-B (NFkB).
MicroRNAs in brain development and physiology.
Review
München, Germany. In Curr Opin Neurobiol, 2009
In detail, they reveal an amazing functional complexity: specific miRNAs can either be used reiteratively, such as miR-9 in patterning, neurogenesis and differentiation, or concomitantly target different mRNAs in distinct cellular compartments, such as Pumilio or Limk1 that can be inhibited by miR-134 to control neuritogenesis or spine growth, respectively.
PDZ and LIM domain-encoding genes: molecular interactions and their role in development.
Review
Leiden, Netherlands. In Scientificworldjournal, 2006
In mammals, there are ten genes that encode for both a PDZ domain, and one or several LIM domains: four genes of the ALP subfamily (ALP, Elfin, Mystique, and RIL), three of the Enigma subfamily (Enigma, Enigma Homolog, and ZASP), the two LIM kinases (LIMK1 and LIMK2), and the LIM only protein 7 (LMO7).
A brain-specific microRNA regulates dendritic spine development.
Impact
Boston, United States. In Nature, 2006
This effect is mediated by miR-134 inhibition of the translation of an mRNA encoding a protein kinase, Limk1, that controls spine development.
LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1.
Impact
GeneRIF
New Haven, United States. In Nat Cell Biol, 2004
LATS1 is a novel cytoskeleton regulator that affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1.
Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.
Impact
Kyoto, Japan. In Cell, 2002
In contrast to the mechanisms of inactivation of ADF/cofilin by kinases such as LIM-kinase 1 (LIMK1), much less is known about its reactivation through dephosphorylation.
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.
Impact
Fukuoka, Japan. In Nature, 1998
Here we show that LIM-kinase 1 (LIMK-1), a serine/threonine kinase containing LIM and PDZ domains, phosphorylates cofilin at Ser 3, both in vitro and in vivo.
