Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension.
Nashville, United States. In Adv Exp Med Biol, 2009
BMPR2 potentially signals through multiple immediate downstream pathways, including Smad, MAPK, LIM domain kinase 1 (LIMK) and dynein, light chain, Tctex-type 1 (TCTEX), v-src sarcoma viral oncogene homolog (SRC), and nuclear factor kappa-B (NFkB).
MicroRNAs in brain development and physiology.
München, Germany. In Curr Opin Neurobiol, 2009
In detail, they reveal an amazing functional complexity: specific miRNAs can either be used reiteratively, such as miR-9 in patterning, neurogenesis and differentiation, or concomitantly target different mRNAs in distinct cellular compartments, such as Pumilio or Limk1 that can be inhibited by miR-134 to control neuritogenesis or spine growth, respectively.
PDZ and LIM domain-encoding genes: molecular interactions and their role in development.
Leiden, Netherlands. In Scientificworldjournal, 2006
In mammals, there are ten genes that encode for both a PDZ domain, and one or several LIM domains: four genes of the ALP subfamily (ALP, Elfin, Mystique, and RIL), three of the Enigma subfamily (Enigma, Enigma Homolog, and ZASP), the two LIM kinases (LIMK1 and LIMK2), and the LIM only protein 7 (LMO7).