In The Journal of Experimental Medicine, 1993
... Antiserum to LIME was produced in the Prague laboratory by immunization of rabbits with bacterially expressed and Talon purified (CLONTECH Laboratories, Inc.) cytoplasmic fragment ...
Modeling nanoparticle wrapping or translocation in bilayer membranes.
Raleigh, United States. In Nanoscale, Oct 2015
By combining LIME, an intermediate resolution, implicit solvent model for phospholipids, with discontinuous molecular dynamics (DMD), we are able to simulate the wrapping or embedding of nanoparticles by 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayer membranes.
Transmembrane adaptor molecules: a new category of lymphoid-cell markers.
Oxford, United Kingdom. In Blood, 2006
In this paper, we report an immunohistologic study of 6 of these molecules in normal and neoplastic human tissue sections and show that they are restricted to subpopulations of lymphoid cells, being present in either T cells (LAT, LIME, and TRIM), B cells (NTAL), or subsets of both cell types (PAG and SIT).
A fast and sensitive method for isolation of detergent-resistant membranes from T cells.
Oslo, Norway. In J Immunol Methods, 2005
The method, which can be completed in 6 h, yields more than 80% of the total content of DRM-associated adaptor molecules LAT (linker for T cell activation), PAG/Cbp (protein associated with glycosphingolipid-enriched microdomains or Csk-binding protein) and LIME (Lck-interacting membrane protein) in low-density fractions using only 2x10(7) T cells.
Adaptors and linkers in T and B cells.
Magdeburg, Germany. In Curr Opin Immunol, 2004
Additional transmembrane adaptors, such as NTAL/LAB and LIME, have been identified and partially characterized.
Transmembrane adaptor proteins in membrane microdomains: important regulators of immunoreceptor signaling.
Praha, Czech Republic. In Immunol Lett, 2004
Most transmembrane proteins are excluded from these specialized areas of membranes, notable exceptions being several palmitoylated proteins such as the T cell coreceptors CD4 and CD8, and several recently described transmembrane adaptor proteins, LAT, non-T cell activation linker (NTAL)/linker for activation of B cells (LAB), phosphoprotein associated with GEMs (PAG)/Csk-binding protein (Cbp) and LIME.