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LIM homeobox protein 1

Lim1, Lhx1
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: LIM, CAN, integrin-linked kinase, ACID, LIM-only
Papers on Lim1
Mutations in WNT9B are associated with Mayer-Rokitansky-Küster-Hauser syndrome.
New
Ledig et al., Münster, Germany. In Clin Genet, Dec 2015
In previous studies, two of the patients with a WNT9B mutation were found to carry either an additional deletion of LHX1 or a missense mutation in TBX6.
Nephron organoids derived from human pluripotent stem cells model kidney development and injury.
New
Impact
Bonventre et al., Boston, United States. In Nat Biotechnol, Nov 2015
The NPCs possess the developmental potential of their in vivo counterparts and form PAX8(+)LHX1(+) renal vesicles that self-organize into nephron structures.
Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo.
New
Tam et al., Sydney, Australia. In Development, Jul 2015
Lhx1 encodes a LIM homeobox transcription factor that is expressed in the primitive streak, mesoderm and anterior mesendoderm of the mouse embryo.
TRPP2-dependent Ca2+ signaling in dorso-lateral mesoderm is required for kidney field establishment in Xenopus.
New
Riou et al., Paris, France. In J Cell Sci, Apr 2015
Knockdown of pkd2 in the kidney field results in the downregulation of pax8, but not of other kidney field genes (lhx1, osr1 and osr2).
PDLIM5 mediates PKCε translocation in PMA-induced growth cone collapse.
New
Chen et al., Guangzhou, China. In Cell Signal, Mar 2015
Furthermore, in neurons, application of PDLIM5 shRNA or over-expression of PDLIM5 LIM1-3 mutants reduced the amount of PKCε in the membrane.
Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development.
New
Umbhauer et al., Paris, France. In Dev Biol, Feb 2015
We further show that Pax8 controls hnf1b, but not lhx1 and Osr2, expression in the kidney field as soon as the mid-neurula stage.
Prenatal diagnosis of 17q12 duplication and deletion syndrome in two fetuses with congenital anomalies.
Liao et al., Guangzhou, China. In Taiwan J Obstet Gynecol, 2014
RESULTS: CMA detected a 1.56-Mb duplication at 17q12 in Fetus 1 and a 1.93-Mb deletion of 17q12 in Fetus 2. Both the duplicated and deleted regions included the HNF1B and LHX1 genes.
DNA methylation analysis of phenotype specific stratified Indian population.
Satyamoorthy et al., India. In J Transl Med, 2014
Bisulfite DNA sequencing of prakriti specific multiple CpG sites in promoters and 5'-UTR such as; LHX1 (Vata prakriti), SOX11 (Pitta prakriti) and CDH22 (Kapha prakriti) were validated.
Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption.
Friederich et al., Luxembourg, Luxembourg. In Plos One, 2014
Similar to zyxin, Tes harbors three highly conserved LIM domains of which the LIM1 domain directly interacts with zyxin.
Transcriptional control of spermatogonial maintenance and differentiation.
Review
Wilkinson et al., San Diego, United States. In Semin Cell Dev Biol, 2014
Most of the transcription factors that have so far been identified as promoting SSC self-renewal (BCL6B, BRACHYURY, ETV5, ID4, LHX1, and POU3F1) are upregulated by glial cell line-derived neurotrophic factor (GDNF).
Modular control of glutamatergic neuronal identity in C. elegans by distinct homeodomain proteins.
Impact
Hobert et al., New York City, United States. In Cell, 2013
Examination of mouse orthologs of these homeodomain proteins resulted in the identification of mouse LHX1 as a regulator of glutamatergic neurons in the brainstem.
From development to cancer: lessons from the kidney to uncover new therapeutic targets.
Review
Massfelder et al., Strasbourg, France. In Anticancer Res, 2012
This review examines the literature on the expression and the roles of neurogenic locus notch homolog protein (NOTCH), sonic Hedgehog (SHH) and wingless-type (WNT) pathways, as well as the nephrogenic transcription factors Wilms' tumor 1 (WT1), paired box 2 (PAX2) and homeobox protein lim-1 (LIM1) in clear cell renal cell carcinoma.
Lim1/LIM1 is expressed in developing and adult mouse and human endometrium.
GeneRIF
Gargett et al., Australia. In Histochem Cell Biol, 2012
Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling
LHX1 mutation screening in 96 patients with müllerian duct abnormalities.
GeneRIF
Chen et al., Jinan, China. In Fertil Steril, 2012
Mutations in the coding regions of LHX1 may not be a common genetic etiologic factor involved in Han Chinese patients with mullerian duct abnormalities.
PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling.
GeneRIF
Rottbauer et al., Heidelberg, Germany. In Mol Cell Biol, 2011
Inactivation of either PINCH isoform independently leads to instability of ILK, loss of stretch-responsive anf and vegf expression, and progressive heart failure
LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma.
GeneRIF
Massfelder et al., Strasbourg, France. In Oncogene, 2011
findings establish that the developmental marker Lim1 acts as an oncogene in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human lear cell carcinoma
Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas.
GeneRIF
Hoefler et al., Graz, Austria. In Pathobiology, 2010
Eleven dysplastic kidneys showed no expression of LIM1. In contrast, 12 of 32 nephroblastomas showed nuclear positivity.
Regulation of spermatogonial stem cell self-renewal in mammals.
Review
Brinster et al., United States. In Annu Rev Cell Dev Biol, 2007
In mouse SSCs, GDNF activation upregulates expression of the transcription factor-encoding genes bcl6b, etv5, and lhx1, which influence SSC self-renewal.
The cellular basis of kidney development.
Review
Dressler, Ann Arbor, United States. In Annu Rev Cell Dev Biol, 2005
Early patterning of the kidney region depends on interactions between Pax/Eya/Six genes, with essential roles for lim1 and Odd1.
Sexual differentiation.
Review
Bellastella et al., Napoli, Italy. In J Endocrinol Invest, 2002
Testis development process involves several steps controlled by other non-OY-linked genes, such as Wilms tumor gene 1 (WT1), EMX2, LIM1, steroidogenic factor 1(SF-1), SRY box-related gene 9 (SOX9).
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