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LIM homeobox protein 1

Lim1, Lhx1
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010] (from NCBI)
Papers on Lim1
Lim1/LIM1 is expressed in developing and adult mouse and human endometrium.
Gargett et al., Australia. In Histochem Cell Biol, 2012
Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling
LHX1 mutation screening in 96 patients with müllerian duct abnormalities.
Chen et al., Jinan, China. In Fertil Steril, 2012
Mutations in the coding regions of LHX1 may not be a common genetic etiologic factor involved in Han Chinese patients with mullerian duct abnormalities.
PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling.
Rottbauer et al., Heidelberg, Germany. In Mol Cell Biol, 2011
Inactivation of either PINCH isoform independently leads to instability of ILK, loss of stretch-responsive anf and vegf expression, and progressive heart failure
LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma.
Massfelder et al., Strasbourg, France. In Oncogene, 2011
findings establish that the developmental marker Lim1 acts as an oncogene in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human lear cell carcinoma
Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas.
Hoefler et al., Graz, Austria. In Pathobiology, 2010
Eleven dysplastic kidneys showed no expression of LIM1. In contrast, 12 of 32 nephroblastomas showed nuclear positivity.
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