gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PDZ and LIM domain 5

LIM
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: Actin, CAN, V1a, LIMK1, cofilin
Papers using LIM antibodies
Optimal and consistent protein glycosylation in mammalian cell culture
Supplier
Wang Jun et al., In Nature biotechnology, 2008
... LimYEngineering mammalian cells in bioprocessing - current achievements and future ...
Dual-color superresolution imaging of genetically expressed probes within individual adhesion complexes
Supplier
Verkhusha Vladislav V. et al., In Nature Methods, 2006
... LimYTSelection of quantum dot wavelengths for biomedical assays and imaging ...
Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway.
Supplier
Caplan Steve H., In PLoS ONE, 2002
... The polyclonal SNX5 antibody was a kind gift from Jet Phey Lim (Bio21 Melbourne).The construct pEGFP-C1 was obtained from Clontech.
Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes
Supplier
Lira Sergio A. et al., In Diabetes, 1994
... Jun HS, Santamaria P, Lim HW, Zhang ML, Yoon JW: Absolute requirement of macrophages for the development and activation of β-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice ...
Papers on LIM
Protein-protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease.
Review
New
de Vries et al., Amsterdam, Netherlands. In Biochim Biophys Acta, Feb 2016
FHL2 belongs to the LIM-domain only proteins and contains four and a half LIM domains, each of which are composed of two zinc finger structures.
Molecular cloning, characterization and tissue specificity of the expression of the ovine CSRP2 and CSRP3 genes from small-tail Han sheep (Ovis aries).
New
Wang et al., China. In Gene, Feb 2016
Alignment and phylogenetic analyses revealed that their amino acid sequences are highly similar to those of other vertebrates, all of which contain two conserved LIM-only domains and a relatively conserved nuclear targeting sequence.
The LMO2 oncogene regulates DNA replication in hematopoietic cells.
New
Hoang et al., Toulouse, France. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: Oncogenic transcription factors are commonly activated in acute leukemias and subvert normal gene expression networks to reprogram hematopoietic progenitors into preleukemic stem cells, as exemplified by LIM-only 2 (LMO2) in T-cell acute lymphoblastic leukemia (T-ALL).
A High-Throughput Screening Platform Targeting PDLIM5 for Pulmonary Hypertension.
New
Zhou et al., Chicago, United States. In J Biomol Screen, Feb 2016
PDLIM5, a member of the Enigma subfamily of PDZ and LIM domain protein family, contains an N-terminal PDZ domain and three LIM domains at its C-terminus.
Four and a half LIM domains 2 contributes to the development of human tongue squamous cell carcinoma.
New
Xu et al., Jinan, China. In J Mol Histol, Feb 2016
UNASSIGNED: Four and a half LIM domains 2 (FHL2) is a protein of 279 amino acids in length containing four full LIM-domains and a half LIM-domain at the amino terminus.
FHL2 mediates tooth development and human dental pulp cell differentiation into odontoblasts, partially by interacting with Runx2.
New
Wang et al., Jinan, China. In J Mol Histol, Feb 2016
Our previous study demonstrated that four and a half LIM domains 2 (FHL2) may play an important role in tooth development and human dental pulp cell differentiation.
Roles of LIM kinases in central nervous system function and dysfunction.
Review
New
Bénédetti et al., Orléans, France. In Febs Lett, Jan 2016
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin.
Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.
Review
New
Lévesque et al., Québec, Canada. In Febs Lett, Jan 2016
LIM-homeodomain (LIM-HD) proteins are evolutionary conserved developmental transcription factors.
FHL2: a scaffold protein of carcinogenesis, tumour-stroma interactions and treatment response.
Review
New
Demetter et al., Brussels, Belgium. In Histol Histopathol, Jan 2016
UNASSIGNED: Four-and-a-half LIM-domain protein 2 (FHL2) is a multifunctional scaffolding protein regulating signalling cascades and gene transcription.
Signal transducer and activator of transcription 3 regulation by novel binding partners.
Review
New
Oritani et al., Sapporo, Japan. In World J Biol Chem, Dec 2015
This article reviews the roles of novel STAT3 binding partners such as DAXX, zipper-interacting protein kinase, Krüppel-associated box-associated protein 1, Y14, PDZ and LIM domain 2 and signal transducing adaptor protein-2, in the regulation of STAT3-mediated signaling.
Genetic association analyses highlight biological pathways underlying mitral valve prolapse.
New
Impact
Leducq Transatlantic MITRAL Network et al., Nantes, France. In Nat Genet, Oct 2015
We highlight LMCD1 (LIM and cysteine-rich domains 1), which encodes a transcription factor and for which morpholino knockdown of the ortholog in zebrafish resulted in atrioventricular valve regurgitation.
Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex.
Impact
Irvine et al., United States. In Cell, 2014
The influence of myosin activity on Yorkie depends genetically on the Ajuba LIM protein Jub, a negative regulator of Warts within the Hippo pathway.
Human but not mouse adipogenesis is critically dependent on LMO3.
Impact
Bilban et al., Vienna, Austria. In Cell Metab, 2013
We now identify the GC-dependent gene LIM domain only 3 (LMO3) as being selectively upregulated in a depot-specific manner in human obese visceral adipose tissue, localizing primarily in the adipocyte fraction.
Lymphatics as a new active player in reverse cholesterol transport.
Impact
Rader et al., Philadelphia, United States. In Cell Metab, 2013
A study in this issue (Lim et al., 2013) suggests that lymphatic vessels are critical for normal RCT and mediate the active trans-endothelial transport of HDL via the HDL receptor SR-BI.
F- and G-actin homeostasis regulates mechanosensitive actin nucleation by formins.
Impact
Watanabe et al., Kyoto, Japan. In Nat Cell Biol, 2013
Overexpressing LIM kinase abrogated the induction of processive mDia1.
Splicing transitions of the anchoring protein ENH during striated muscle development.
GeneRIF
Maturana et al., Nagaoka, Japan. In Biochem Biophys Res Commun, 2012
coordinated and stepwise splicing transitions result in the production of specific ENH transcripts in mature striated muscles.
LIM domains regulate protein kinase C activity: a novel molecular function.
GeneRIF
Kuroda et al., Ōsaka, Japan. In Cell Signal, 2011
LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner.
Loss of enigma homolog protein results in dilated cardiomyopathy.
GeneRIF
Chen et al., San Diego, United States. In Circ Res, 2010
Deletion of ENH leads to destabilization of this protein complex and dilated cardiomyopathy in mice.
Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy.
GeneRIF
Maturana et al., Genève, Switzerland. In Cardiovasc Res, 2010
Antagonistic splice variants of enigma may play a central role in the adaptive changes of the link between mechanical stress-sensing and signalling occurring during embryonic development and/or heart hypertrophy.
Positive association between the PDLIM5 gene and bipolar disorder in the Chinese Han population.
GeneRIF
Yu et al., Shanghai, China. In J Psychiatry Neurosci, 2009
Our results suggest that PDLIM5 might play a role in susceptibility to bipolar disorder among the Chinese Han population.
share on facebooktweetadd +1mail to friends