The LMO2 oncogene regulates DNA replication in hematopoietic cells.
Toulouse, France. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: Oncogenic transcription factors are commonly activated in acute leukemias and subvert normal gene expression networks to reprogram hematopoietic progenitors into preleukemic stem cells, as exemplified by LIM-only 2 (LMO2) in T-cell acute lymphoblastic leukemia (T-ALL).
LIM-domain-only proteins in cancer.
Sydney, Australia. In Nat Rev Cancer, 2013
In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implicated in the onset or the progression of several cancers, including T cell leukaemia, breast cancer and neuroblastoma.
Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
Philadelphia, United States. In Nature, 2011
data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression