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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

LIM domain only 1

LIM-only, LMO1, TTG1, RBTN1
This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012] (from NCBI)
Top mentioned proteins: LIM, CAN, LMO2, FHL2, LMO4
Papers using LIM-only antibodies
Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins
Supplier
Allan Andrew C et al., In The Plant Journal, 2003
... TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in ...
Papers on LIM-only
Protein-protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease.
Review
New
de Vries et al., Amsterdam, Netherlands. In Biochim Biophys Acta, Feb 2016
FHL2 belongs to the LIM-domain only proteins and contains four and a half LIM domains, each of which are composed of two zinc finger structures.
[Corrigendum] Upregulated LMO1 in prostate cancer acts as a novel coactivator of the androgen receptor.
New
Li et al., Shenyang, China. In Int J Oncol, Feb 2016
UNASSIGNED: After the publication of the article, the authors decided to add the following grants in the Acknowledgements section: This study was supported by grants from the National Natural Science Foundation of China (Nos.
Molecular cloning, characterization and tissue specificity of the expression of the ovine CSRP2 and CSRP3 genes from small-tail Han sheep (Ovis aries).
New
Wang et al., China. In Gene, Feb 2016
Alignment and phylogenetic analyses revealed that their amino acid sequences are highly similar to those of other vertebrates, all of which contain two conserved LIM-only domains and a relatively conserved nuclear targeting sequence.
The LMO2 oncogene regulates DNA replication in hematopoietic cells.
New
Hoang et al., Toulouse, France. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: Oncogenic transcription factors are commonly activated in acute leukemias and subvert normal gene expression networks to reprogram hematopoietic progenitors into preleukemic stem cells, as exemplified by LIM-only 2 (LMO2) in T-cell acute lymphoblastic leukemia (T-ALL).
A Polymorphism in the LMO1 Super-Enhancer Mediates Neuroblastoma Risk.
New
In Cancer Discov, Jan 2016
A polymorphism in the LMO1 super-enhancer protects against neuroblastoma.
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.
New
Impact
Maris et al., Philadelphia, United States. In Nature, Jan 2016
A previous genome-wide association study identified common polymorphisms at the LMO1 gene locus that are highly associated with neuroblastoma susceptibility and oncogenic addiction to LMO1 in the tumour cells.
Hairy Canola (Brasssica napus) re-visited: Down-regulating TTG1 in an AtGL3-enhanced hairy leaf background improves growth, leaf trichome coverage, and metabolite gene expression diversity.
New
Gruber et al., Saskatoon, Canada. In Bmc Plant Biol, Dec 2015
In Arabidopsis, a network of three classes of proteins consisting of TTG1 (a WD40 repeat protein), GL3 (a bHLH factor) and GL1 (a MYB transcription factor), activates trichome initiation and patterning.
The FHL2 regulation in the transcriptional circuitry of human cancers.
Review
New
Tsui et al., Hong Kong, Hong Kong. In Gene, Dec 2015
The Four-and-a-half LIM (FHL)-only protein is a subfamily of protein members under the LIM-only protein family.
Ternary WD40 Repeat-Containing Protein Complexes: Evolution, Composition and Roles in Plant Immunity.
Review
Clay et al., New Haven, United States. In Front Plant Sci, 2014
The WD40 repeat (WDR)-containing proteins Gβ and TTG1 are constituents of two independent ternary protein complexes functioning at opposite ends of a plant immune signaling pathway.
LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.
Review
Geng et al., Shijiazhuang, China. In Mol Biol Rep, 2014
To date, four LIM-domain-only (LMO) proteins (LMO1-LMO4) have been identified.
Friend or foe: can activating mutations in NOTCH1 contribute to a favorable treatment outcome in patients with T-ALL?
Review
Berger et al., Jerusalem, Israel. In Crit Rev Oncog, 2013
Transformation events occur during crucial steps of thymocyte development and have been related to the expression of certain oncogenes such as TAL2, TLX1, LYL1, LMO1, and NOTCH1.
LIM-domain-only proteins in cancer.
Review
Impact
Curtis et al., Sydney, Australia. In Nat Rev Cancer, 2013
In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implicated in the onset or the progression of several cancers, including T cell leukaemia, breast cancer and neuroblastoma.
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Impact
Look et al., Boston, United States. In Cancer Cell, 2012
Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1/2, GATA3, and RUNX1.
Genome-wide analysis of DNA methylation and the gene expression change in lung cancer.
GeneRIF
Park et al., Seoul, South Korea. In J Thorac Oncol, 2012
We confirmed that the expression of LMO3 in squamous cell carcinoma is regulated by DNA methylation of its specific promoter region.
Nuclear trapping by GL3 controls intercellular transport and redistribution of TTG1 protein in Arabidopsis.
GeneRIF
Hülskamp et al., Köln, Germany. In Development, 2011
TTG1 trapping by GL3 is based on direct interaction between both proteins and recruitment in the nucleus.
Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse.
GeneRIF
Heberlein et al., San Francisco, United States. In Alcohol Clin Exp Res, 2011
when tested for behavioral responses to ethanol, transgenic mice exhibited altered ethanol sedation and consumption that correlated with Lmo3 expression levels; results suggest a role for Lmo3 in ethanol-related behaviors in mice
Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1).
GeneRIF
Tomlinson et al., San Antonio, United States. In Carcinogenesis, 2011
genetic variants within LMO1 are associated with acute lymphoblastic leukemia and identify this gene as a strong candidate for precursor B-cell leukemogenesis.
Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
Impact
GeneRIF
Maris et al., Philadelphia, United States. In Nature, 2011
data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression
Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.
GeneRIF
Nakagawara et al., Chiba, Japan. In Plos One, 2010
The present results suggest that a transcriptional complex of LMO3 and HEN2 may contribute to the genesis and malignant phenotype of neuroblastoma by inhibiting HES1 which suppresses the transactivation of Mash1.
A chromatin link that couples cell division to root epidermis patterning in Arabidopsis.
Impact
Gutierrez et al., Madrid, Spain. In Nature, 2007
GEM also interacts with TTG1 (TRANSPARENT TESTA GLABRA1), a WD40-repeat protein involved in GL2-dependent cell fate decision, and modulates both cell division and GL2 expression.
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