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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ubiquitin-conjugating enzyme E2K

Lig, E2-25K, HIP2
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, V1a, ACID, HAD
Papers using Lig antibodies
Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment
Supplier
Borst Jannie et al., In The Journal of Cell Biology, 2004
... ), anti-GFP (Clontech Laboratories, Inc.), anti-E2-25K UG9520 (BIOMOL International, L.P.) ...
Papers on Lig
Comparison on batch anaerobic digestion of five different livestock manures and prediction of biochemical methane potential (BMP) using different statistical models.
New
Chen et al., Pullman, United States. In Waste Manag, Feb 2016
Single variable and multiple variable regression models were developed using manure total carbohydrate (TC), crude protein (CP), total fat (TF), lignin (LIG) and acid detergent fiber (ADF), and measured BMP data.
Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.
New
Bothwell et al., Seattle, United States. In Mol Cell Neurosci, Jan 2016
The three Trk paralogs are members of the LIG superfamily of membrane proteins, which share extracellular domains consisting of leucine-rich repeat and C2 Ig domains.
UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila.
New
Yoo et al., Kwangju, South Korea. In Biochem Biophys Res Commun, Jan 2016
RNAi-mediated knockdown of the UbcD4 ortholog, E2-25K/Ube2K, inhibited TNFα- and LPS-mediated activation of the NF-κB pathway, implying that UbcD4 and E2-25K/Ube2K play a conserved role as positive regulators in both pathways.
Integrating Paleodistribution Models and Phylogeography in the Grass-Cutting Ant Acromyrmex striatus (Hymenoptera: Formicidae) in Southern Lowlands of South America.
New
Heinze et al., Viçosa, Brazil. In Plos One, Dec 2015
Paleodistribution models suggest that the potential habitat of A. striatus may have decreased during the Last Interglacial Period (LIG) and expanded during the Last Maximum Glacial (LGM).
Increased Rat Placental Fatty Acid, But Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming.
New
Nüsken et al., Köln, Germany. In J Cell Biochem, Dec 2015
Pregnant rats underwent bilateral uterine artery and vein ligation (LIG), sham operation (SOP) or no operation (controls, C) on gestational day E19.
Higher-intensity exercise helps cancer survivors remain motivated.
New
Naumann et al., Seaside, United States. In J Cancer Surviv, Dec 2015
Intervention participants were randomized to low-to-moderate intensity exercise (LIG; n = 44; 60-65 % VO2peak, 50-65 % one repetition maximum (1RM)) or moderate-to-high intensity exercise (HIG; n = 40; 75-80 % VO2peak, 65-80 % 1RM) while controls continued usual care.
Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.
New
Patel et al., Waltham, United States. In Bioorg Med Chem Lett, Dec 2015
Two novel compounds, pyridopyrimidines (1) and naphthyridines (2) were identified as potent inhibitors of bacterial NAD(+)-dependent DNA ligase (Lig) A in a fragment screening.
Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans.
New
Isaac et al., São Paulo, Brazil. In Plos Negl Trop Dis, Oct 2015
Therefore, C4BP and heparin may share the same binding sites on Lig proteins.
Climatic Factors Drive Population Divergence and Demography: Insights Based on the Phylogeography of a Riparian Plant Species Endemic to the Hengduan Mountains and Adjacent Regions.
Sun et al., Kunming, China. In Plos One, 2014
Three chloroplast DNA (cpDNA) regions (trnD-trnT, psbD-trnT, petL-psbE), one single copy nuclear gene (glyceraldehyde 3-phosphate dehydrogenase; G3pdh), and climatic data during the Last Interglacial (LIG; c. 120-140 ka), Last Glacial Maximum (LGM; c.
Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time.
Review
Tainer et al., Berkeley, United States. In Dna Repair (amst), 2014
X-ray crystal structures, cryo-electron microscopy envelopes, and small angle X-ray scattering (SAXS) solution conformations and assemblies are defining most of the core protein components for NHEJ: Ku70/Ku80 heterodimer; the DNA dependent protein kinase catalytic subunit (DNA-PKcs); the structure-specific endonuclease Artemis along with polynucleotide kinase/phosphatase (PNKP), aprataxin and PNKP related protein (APLF); the scaffolding proteins XRCC4 and XLF (XRCC4-like factor); DNA polymerases, and DNA ligase IV (Lig IV).
Structure and function of the DNA ligases encoded by the mammalian LIG3 gene.
Review
Sallmyr et al., Albuquerque, United States. In Gene, 2014
Among the mammalian genes encoding DNA ligases (LIG), the LIG3 gene is unique in that it encodes multiple DNA ligase polypeptides with different cellular functions.
Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K.
GeneRIF
Twigg et al., Huntsville, United States. In Nat Prod Commun, 2011
An extract of bark from the tropical rainforest plant Byrsonima crassifolia was screened for inhibition of diubiquitin formation by the human ubiquitin-conjugating enzyme E2-25K.
The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity.
GeneRIF
Twigg et al., Huntsville, United States. In Biochem Biophys Res Commun, 2011
one of the roles of the C-terminal UBA domain, in the context of E2-25K, is to increase processivity in Lys48-linked polyubiquitin chain synthesis, possibly through increased binding to the ubiquitinated substrate.
Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity.
GeneRIF
Lee et al., Seoul, South Korea. In J Biol Chem, 2010
Results suggest that the interaction between E2-25K and UBB(+1) is critical for the synthesis and accumulation of UBB(+1)-anchored polyubiquitin, which results in proteasomal inhibition and neuronal cell death.
Hip2 interacts with and destabilizes Smac/DIABLO.
GeneRIF
Kang et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2010
This study suggests that Hip2 might be involved in the regulation of Smac-mediated apoptosis.
Preparation of sumoylated substrates for biochemical analysis.
Review
Pichler et al., Boston, United States. In Methods Mol Biol, 2008
Here, we describe the purification of the ubiquitin conjugating enzyme E2-25K, its in vitro sumoylation with recombinant enzymes and the subsequent separation and purification of the modified and the unmodified forms.
E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity.
GeneRIF
Jung et al., Seoul, South Korea. In J Cell Biol, 2008
E2-25K/Hip-2 is thus an essential upstream regulator of the expression and activation of caspase-12 in endoplasmic reticulum stress-mediated Abeta neurotoxicity.
Sequential E2s drive polyubiquitin chain assembly on APC targets.
Impact
Morgan et al., San Francisco, United States. In Cell, 2007
The anaphase-promoting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiquitin-conjugating enzymes to assemble polyubiquitin chains on proteins important for cell-cycle progression.
Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity.
Review
Hara et al., Gifu, Japan. In Cns Drug Rev, 2006
Lig-8, a lignophenol derivative from bamboo lignin, is a highly potent neuroprotectant.
Alzheimer's disease meets the ubiquitin-proteasome system.
Review
Jung et al., Kwangju, South Korea. In Trends Mol Med, 2004
Interestingly, recent evidence, including studies of E2-25K/Hip-2, has elucidated the molecular mechanism of the ubiquitin-proteasome system (UPS) malfunction in AD.
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