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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Leukemia inhibitory factor

LIF, leukemia inhibitory factor
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: CAN, STAT3, Interleukin-6, V1a, Nanog
Papers using LIF antibodies
Pharmacological inhibitors of glycogen synthase kinase 3.
Supplier
Cooney Austin John, In PLoS ONE, 2003
... As indicated, the medium also contained 1,000 U/mL mouse LIF (ESG1107, Chemicon), various concentrations of SB-216763 (BIOMOL International), BIO (Cayman Chemical), ...
Embryonic Stem Cells As an Alternate Marrow Donor Source
Supplier
Link Charles et al., In The Journal of Experimental Medicine, 2001
... -glutamine, 0.1 mM β-mercaptoethanol, 1× nonessential amino acids, 1× sodium pyruvate, and 1,000 U/ml LIF (Specialty Media and StemCell Technologies Inc.) ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Supplier
Hu Wei-Shou, In PLoS Computational Biology, 2000
... 0.1 mM nonessential amino acids, 2 mM glutamine, 100 U/mL penicillin, 100 μg/mL streptomycin, 10 ng/mL LIF (all reagents from StemCell Technologies, ...
A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD.
Supplier
Wu Qiang, In PLoS ONE, 2000
... Japan) -treated SNL feeder cells in DMEM, supplemented with 10% FBS, NEAA, 2-melcapt ethanol, L-Gln, LIF, at 37C, in 5% CO2, and passaged every 3 days using TrypleExpress (invitrogen, Life Technologies Corp., Carlsbad, CA, USA) ...
Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation
Supplier
Yurchenco Peter D. et al., In The Journal of Cell Biology, 1996
... mM β-mercaptoethanol, 1 mM sodium pyruvate, 100 μg/ml penicillin, 100 μg /ml streptomycin, and 1,000 U/ml leukemia inhibitory factor (LIF; Life Technologies).
Papers on LIF
Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital disorder of glycosylation.
New
Buettner et al., Hannover, Germany. In Mol Cell Proteomics, Feb 2016
By multiplexed capillary gel electrophoresis coupled to laser induced fluorescence detection (xCGE-LIF) we could show that PMM2-iPSC-C3 exhibit the common hPSC N-glycosylation pattern with high-mannose-type N-glycans as the predominant species.
Induced pluripotent stem cells with six reprogramming factors from Prairie Vole, which is an animal model for social behaviors.
New
Fukuda et al., In Cell Transplant, Feb 2016
Furthermore, the established prairie vole iPS cells tested positive for stem cell markers, including alkaline phosphatase activity (ALP), stage-specific embryonic antigen (SSEA)-1, and dependence on leukemia inhibitory factor (LIF).
Dysregulated LIF and its receptor regulated STAT3 pathway: a possible cause for repeated implantation failure in women with dormant genital tuberculosis?
New
Chaudhury et al., Kharagpur, India. In Fertil Steril, Feb 2016
OBJECTIVE: To investigate the influence of dormant Mycobacterium tuberculosis on the expression of various endometrial receptivity markers and leukemia inhibitory factor (LIF)-signal transducers and activators of transcription 3 (STAT3) signaling pathway.
Human neutrophil elastase inhibition studied by capillary electrophoresis with laser induced fluorescence detection (LIF) and microscale thermophoresis (MST).
New
Morin et al., Orléans, France. In J Chromatogr A, Feb 2016
UNASSIGNED: Capillary electrophoresis-laser induced fluorescence (CZE-LIF) and microscale thermophoresis (MST) were used for the first time to study the inhibition of human neutrophil elastase (HNE).
Cytokines and Blastocyst Hatching.
Review
New
Madhulika et al., Bengaluru, India. In Am J Reprod Immunol, Jan 2016
Pro-inflammatory (IL-6, LIF, GM-CSF) and anti-inflammatory (IL-11, CSF-1) cytokines improve hatching rates; they modulate proteases (MMPs, tPAs, cathepsins and ISP1).
Gene set enrichment and topological analyses based on interaction networks in pediatric acute lymphoblastic leukemia.
New
Ji et al., Dongying, China. In Oncol Lett, Dec 2015
In total, 398 DE genes were identified in pediatric ALL, and LIF was the most significantly DE gene.
The Current State of Naïve Human Pluripotency.
Review
New
Cowley et al., Oxford, United Kingdom. In Stem Cells, Nov 2015
Maintenance of these ground state cells is possible using a combination of basic fibroblast growth factor and human leukemia inhibitory factor together with dual inhibition of glycogen synthase kinase 3 beta, and mitogen-activated protein kinase kinase (MEK).
Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming.
New
Impact
Meissner et al., Cambridge, United States. In Cell Stem Cell, Nov 2015
Mouse embryonic stem cells (mESCs) cultured under serum/LIF conditions exhibit heterogeneous expression of pluripotency-associated factors that can be overcome by two inhibitors (2i) of the MEK and GSK3 pathways.
Sensitive probes of protein structure and dynamics in well-controlled environments: combining mass spectrometry with fluorescence spectroscopy.
Review
New
Jockusch et al., Toronto, Canada. In Curr Opin Struct Biol, Oct 2015
Combining the selectivity of mass spectrometry (MS) with laser-induced fluorescence (LIF) presents a promising route to probe the intrinsic conformation, stability and dynamics of biological macromolecules.
Leukemia inhibitory factor (LIF).
Review
New
Babon et al., Melbourne, Australia. In Cytokine Growth Factor Rev, Oct 2015
Leukemia inhibitory factor (LIF) is the most pleiotropic member of the interleukin-6 family of cytokines.
LIF signaling in stem cells and development.
Review
New
Zandstra et al., Toronto, Canada. In Development, Aug 2015
Leukemia inhibitory factor (LIF) is a member of the interleukin-6 (IL-6) cytokine family.
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells.
New
Impact
Kirschner et al., Boston, United States. In Cell, Jun 2015
We analyzed mouse embryonic stem cells, revealing in detail the population structure and the heterogeneous onset of differentiation after leukemia inhibitory factor (LIF) withdrawal.
Klf2 is an essential factor that sustains ground state pluripotency.
Impact
Ng et al., Singapore, Singapore. In Cell Stem Cell, 2014
The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum.
Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit.
Impact
Nowak et al., Heidelberg, Germany. In Cell Stem Cell, 2014
Overproduction of niche factors such as CDH2 (N-Cadherin), IGFBP2, VEGFA, and LIF is associated with the ability of MDS MSCs to enhance MDS expansion.
Bidirectional developmental potential in reprogrammed cells with acquired pluripotency.
Impact
Wakayama et al., Kōbe, Japan. In Nature, 2014
Mouse STAP cells lose the ability to contribute to the placenta as well as trophoblast marker expression on converting into ES-like stem cells by treatment with adrenocorticotropic hormone (ACTH) and leukaemia inhibitory factor (LIF).
Pinopodes, leukemia inhibitory factor, integrin-β3, and mucin-1 expression in the peri-implantation endometrium of women with unexplained recurrent pregnancy loss.
GeneRIF
Feng et al., Shanghai, China. In Fertil Steril, 2012
Expression of LIF and integrin-beta3 (ITGB3) in the peri-implantation endometrium does not change in women with unexplained recurrent pregnancy loss.
K/B×N serum transfer arthritis is delayed and less severe in leukaemia inhibitory factor (LIF)-deficient mice.
GeneRIF
Jazayeri et al., Australia. In Clin Exp Immunol, 2012
These results provide further evidence for the role of LIF in inflammation and cartilage bone resorption and provide impetus to test the effects of LIF blockade as a therapeutic strategy in rheumatoid arthritis.
Deficient leukemia inhibitory factor signaling in muscle precursor cells from patients with type 2 diabetes.
GeneRIF
Scheele et al., Copenhagen, Denmark. In Am J Physiol Endocrinol Metab, 2012
Although leukemia inhibitory factor (LIF) and LIF receptors were increased in muscle tissue and myoblasts from diabetic patients, LIF signaling and LIF-induced cell proliferation were impaired in diabetic myoblasts.
Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells.
GeneRIF
Laird et al., Sheffield, United Kingdom. In Hum Reprod, 2012
there is an altered expression of LIF and IL-15 in the endometrium of women with recurrent implantation failure
Leukemia inhibitory factor signaling is required for lung protection during pneumonia.
GeneRIF
Allen et al., Boston, United States. In J Immunol, 2012
The LIF-STAT3 axis is identified in this study as a critical determinant of lung injury with clinical implications for pneumonia patients.
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