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LIM homeobox protein 6

Lhx6
This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LIM, l-3, CAN, RGS, V1a
Papers using Lhx6 antibodies
Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
Supplier
Xie Zhongcong, In PLoS ONE, 2009
... Hemizygous I12b-Cre mice were also bred with Lhx6-GFP BAC transgenic mice, in which GFP ...
Papers on Lhx6
Dysfunctional subcutaneous fat with reduced Dicer and brown adipose tissue gene expression in HIV-infected patients.
New
Grinspoon et al., Bethesda, United States. In J Clin Endocrinol Metab, Feb 2016
LHX6 (P=0.03),
Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2.
New
Jeong et al., New York City, United States. In Hum Mol Genet, Oct 2015
Lhx6 and Lhx8 encode LIM homeodomain transcription factors, and inactivation of both genes in mice resulted in profound craniofacial defects including cleft secondary palate.
LHX6 inhibits breast cancer cell proliferation and invasion via repression of the Wnt/β-catenin signaling pathway.
New
Xie et al., Kaifeng, China. In Mol Med Report, Sep 2015
LIM homeobox domain 6 (LHX6), a member of the LHX family of proteins, has been implicated in cancer development.
The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C. elegans Sensory/Inter/Motor Neuron-Type.
New
Kim et al., Taegu, South Korea. In Plos Genet, Aug 2015
Two human LIM-4 orthologs, LHX6 and LHX8, functionally substitute for LIM-4 in C. elegans.
Altered retinoic acid signalling underpins dentition evolution.
New
Laudet et al., Lyon, France. In Proc Biol Sci, Apr 2015
Expression analysis of pharyngeal mesenchyme markers such as dlx2a and lhx6 shows lateral, anterior and dorsal expansion of these markers in RA-treated embryos, whereas the expression of the dental epithelium markers dlx2b and dlx3b is unchanged.
Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina.
Gan et al., Rochester, United States. In Gene Expr Patterns, 2014
Here we report a detailed expression study of LIM-HD transcription factors LHX9 and LHX2, LHX3 and LHX4, and LHX6 in the developing and mature mouse retina using immunohistochemistry and in situ hybridization techniques.
Candidate gene studies in hypodontia suggest role for FGF3.
Modesto et al., Pittsburgh, United States. In Eur Arch Paediatr Dent, 2013
The second Brazilian cohort also suggested that FGF3 (rs12574452, p = 0.01) is associated with hypodontia and added EDAR (rs17269487, p = 0.04), LHX6 (rs989798, p = 0.02), and MSX1 (rs12532, p = 0.003).
Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer.
Yazawa et al., Yokohama, Japan. In Lab Invest, 2013
Transfection experiments using expression vectors for FOXA1, FOXA2, LHX2, LHX6, and BRN2 showed that BRN2 substantially upregulated TTF1 expression, whereas FOXA1/2 weakly upregulated TTF1 expression.
The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis.
Amendt et al., Houston, United States. In J Biol Chem, 2013
LHX6 is a LIM-homeobox transcription factor expressed during embryogenesis; however, the molecular mechanisms regulating LHX6 transcriptional activities are unknown.
LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer.
Liu et al., Chongqing, China. In Cell Death Dis, 2012
LIM homeobox domain 6 (LHX6) is a putative transcriptional regulator that controls the differentiation and development of neural and lymphoid cells.
Inductive ability of human developing and differentiated dental mesenchyme.
Zhang et al., San Francisco, United States. In Cells Tissues Organs, 2012
Transcription factors were significantly upregulated in FDMCs compared to ADMCs including MSX1, GLI1, LHX6, LHX8,LEF1 and TBX1.
Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons.
Pachnis et al., London, United Kingdom. In Cell Rep, 2012
The LIM-homeodomain protein LHX6 is critical for the development of all cortical interneurons originating in the medial ganglionic eminence, but the molecular mechanisms that operate downstream of LHX6 to control the terminal differentiation of somatostatin- and parvalbumin-expressing interneurons within the cortex remain unknown.
Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome.
GeneRIF
Grigoriou et al., Greece. In Genes Brain Behav, 2012
found positive association of LHX6 with Tourette syndrome in some European populations, not others. LHX6 demonstrates a high degree of population differentiation and is correlated with the North to South axis of European genetic variation.
Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex.
Hashimoto et al., Kanazawa, Japan. In Plos One, 2011
Based on previously reported expression patterns in the cortex of mice and humans, we selected four genes: KCNS3, LHX6, KCNAB1, and PPP1R2, encoding K(+) channel Kv9.3 modulatory α-subunit, LIM homeobox protein 6, K(+) channel Kvβ1 subunit, and protein phosphatase 1 regulatory subunit 2, respectively, and examined their colocalization with PV or SST mRNAs in the human prefrontal cortex using dual-label in situ hybridization with (35)S- and digoxigenin-labeled antisense riboprobes.
Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors.
GeneRIF
Rubenstein et al., San Francisco, United States. In Neuron, 2011
Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors.
Epigenetic regulation of the potential tumor suppressor gene, hLHX6.1, in human cervical cancer.
GeneRIF
Lee et al., Seoul, South Korea. In Int J Oncol, 2011
hLHX6.1 could be a new tumor suppressor gene in the cervix.
A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives.
Elefanty et al., Australia. In Stem Cells, 2011
NKX2.1-GFP(+) progenitors expressed genes characteristic of the basal forebrain, including SHH, DLX1, LHX6, and OLIG2.
The role of hLHX6-HMR as a methylation biomarker for early diagnosis of cervical cancer.
GeneRIF
Lee et al., Seoul, South Korea. In Oncol Rep, 2010
Hypermethylation of LHX6 is associated with cervical cancer.
Purification of caudal-related homeodomain transcription factor and its binding characterization.
GeneRIF
Jang et al., Pusan, South Korea. In J Microbiol Biotechnol, 2009
Studied the DNA binding activity of human CDX2. Three CDX2-binding proteins were found in rat gastric tissue, and those proteins were identified to the homeobox protein Hox-D8, LIM homeobox protein 6, and SMC1L1 protein.
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