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Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

LH3, lysyl hydroxylase 3, PLOD3
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LH beta, CAN, ACID, OUT, glycosyltransferase
Papers on LH3
The interaction of Mozobil(™) with carboxylates.
New
Mangano et al., Pavia, Italy. In Org Biomol Chem, Feb 2016
(1)H NMR titration experiments have shown that in the 7-10 pH interval, LH3(3+), LH2(2+) and LH(+) forms establish π-π interactions with diphenyl-4,4'-dicarboxylate, according to a topological arrangement which excludes the formation of H-bonds.
Localization of collagen modifying enzymes on fibroblastic reticular cells and follicular dendritic cells in non-neoplastic and neoplastic lymphoid tissues.
New
Yamakawa et al., Yamagata, Japan. In Leuk Lymphoma, Jan 2016
The expression of prolyl 4-hydroxylase 1 (P4H1), lysyl hydroxylase 3 (LH3), and protein disulfide isomerase (PDI) was frequently observed on FRCs and FDCs in the germinal center (GC), except for the mantle zone.
Protic Ruthenium Tris(pyrazol-3-ylmethyl)amine Complexes Featuring a Hydrogen-Bonding Network in the Second Coordination Sphere.
New
Kuwata et al., Tokyo, Japan. In Inorg Chem, Jan 2016
We synthesized ruthenium complexes bearing a tris(pyrazol-3-ylmethyl)amine ligand LH3 and revealed that this tripodal ligand allows predictable accumulation of three proton-delivering NH groups around a coordination site.
The dissociation constants of the cytostatic bosutinib by nonlinear least-squares regression of multiwavelength spectrophotometric and potentiometric pH-titration data.
New
Pekárek et al., Pardubice, Czech Republic. In J Pharm Biomed Anal, Jan 2016
With an increasing content of methanol in solvent the dissociation of bosutinib is suppressed and the percentage of LH3(2+) decreases and LH prevails.
The IκB kinase inhibitor ACHP strongly attenuates TGFβ1-induced myofibroblast formation and collagen synthesis.
New
Bank et al., Groningen, Netherlands. In J Cell Mol Med, Dec 2015
Finally, ACHP suppressed the expression of the three collagen-modifying enzymes lysyl hydroxylase (PLOD1, PLOD2 and PLOD3) in dermal fibroblasts, but did not do so in lung fibroblasts.
Pentanuclear [2.2] spirocyclic lanthanide(iii) complexes: slow magnetic relaxation of the Dy(III) analogue.
New
Chandrasekhar et al., Kānpur, India. In Dalton Trans, Dec 2015
The reaction of LnCl3·6H2O (Ln = Dy(3+), Tb(3+) and Ho(3+)) with the multisite coordinating ligand N'-(2-hydroxy-3-(hydroxymethyl)-5-methylbenzylidene)acetohydrazide (LH3) in the presence of pivalic acid (PivH) leads to the formation of three isostructural homometallic pentanuclear complexes, [Dy5(LH)4(η(1)-Piv)(η(2)-Piv)3(μ2-η(2)η(1)Piv)2(H2O)]·Cl·9·5H2O·5MeOH (1), [Tb5(LH)4(η(1)-Piv)(η(2)-Piv)3(μ2-η(2)η(1)Piv)2(H2O)]·Cl·10.5H2O·2MeOH·2CHCl3
The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration.
New
Granato et al., Philadelphia, United States. In Neuron, Dec 2015
We show that this process requires the glycosyltransferase lh3 and that post-injury expression of lh3 in Schwann cells is sufficient to restore target-selective regeneration.
Decanuclear Ln10 Wheels and Vertex-Shared Spirocyclic Ln5 Cores: Synthesis, Structure, SMM Behavior, and MCE Properties.
New
Chandrasekhar et al., Bhubaneshwar, India. In Chemistry, Dec 2015
The reaction of a Schiff base ligand (LH3 ) with lanthanide salts, pivalic acid and triethylamine in 1:1:1:3 and 4:5:8:20 stoichiometric ratios results in the formation of decanuclear Ln10 (Ln=Dy(1), Tb(2), and Gd (3)) and pentanuclear Ln5 complexes (Ln=Gd (4), Tb (5), and Dy (6)), respectively.
FermiKit: assembly-based variant calling for Illumina resequencing data.
New
Li, Cambridge, United States. In Bioinformatics, Dec 2015
AVAILABILITY AND IMPLEMENTATION: https://github.com/lh3/fermikit
BGT: efficient and flexible genotype query across many samples.
New
Li, Cambridge, United States. In Bioinformatics, Nov 2015
AVAILABILITY AND IMPLEMENTATION: https://github.com/lh3/bgt
Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa.
South et al., Dundee, United Kingdom. In Plos One, 2014
Here, we identify a significant decrease in PLOD3 expression and its encoded protein, the collagen modifying enzyme lysyl hydroxylase 3 (LH3), in RDEB.
Toward better understanding of artifacts in variant calling from high-coverage samples.
Review
Li, Cambridge, United States. In Bioinformatics, 2014
AVAILABILITY AND IMPLEMENTATION: BWA-MEM alignment and raw variant calls are available at http://bit.ly/1g8XqRt scripts and miscellaneous data at https://github.com/lh3/varcmp.
Lysyl hydroxylase 3-mediated glucosylation in type I collagen: molecular loci and biological significance.
GeneRIF
Yamauchi et al., Chapel Hill, United States. In J Biol Chem, 2012
LH3-mediated glucosylation occurs at the specific molecular loci in the type I collagen molecule and plays critical roles in controlling collagen cross-linking, fibrillogenesis, and mineralization.
Lysyl hydroxylase 3 is secreted from cells by two pathways.
GeneRIF
Myllylä et al., Oulu, Finland. In J Cell Physiol, 2012
LH3 molecules found in the cell medium are secreted through the Golgi complex, and the secretion is dependent on LH3 glycosyltransferase activity; LH3 found on the cell surface bypasses the Golgi complex
The effects of protein crowding in bacterial photosynthetic membranes on the flow of quinone redox species between the photochemical reaction center and the ubiquinol-cytochrome c2 oxidoreductase.
Review
Niederman et al., United States. In Metallomics, 2011
molischianum, the crowding of the ICM with LH3 has little effect upon UQ diffusion.
Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture.
GeneRIF
Yamauchi et al., Chapel Hill, United States. In J Biol Chem, 2011
the major function of LH3 in osteoblasts is to glucosylate galactosylhydroxylysine residues in type I collagen and that an impairment of this LH3 function significantly affects type I collagen fibrillogenesis.
Dimerization of human lysyl hydroxylase 3 (LH3) is mediated by the amino acids 541-547.
GeneRIF
Myllylä et al., Oulu, Finland. In Matrix Biol, 2011
Dimerization of human lysyl hydroxylase 3 is mediated by the amino acids 541-547
Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix.
GeneRIF
Myllylä et al., Oulu, Finland. In J Biol Chem, 2009
Results report an important role for lysyl hydroxylase 3 in the organization of the extracellular matrix (ECM) and cytoskeleton.
[Progress on pigment-protein complexes from anoxygenic phototrophic bacteria--a review].
Review
Qu et al., Xiamen, China. In Wei Sheng Wu Xue Bao, 2009
In particular, we depicted the novel light-harvesting complexes namely LH3 and LH4.
Expanding the lysyl hydroxylase toolbox: new insights into the localization and activities of lysyl hydroxylase 3 (LH3).
Review
Sipilä et al., Oulu, Finland. In J Cell Physiol, 2007
One of the lysyl hydroxylase isoforms, lysyl hydroxylase 3 (LH3), has been shown to possess three catalytic activities required sequentially to produce hydroxylysine and its glycosylated forms, that is, the lysyl hydroxylase (LH), galactosyltransferase (GT), and glucosyltransferase (GGT) activities.
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