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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 03 Jul 2015.

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

LH beta, lysyl hydroxylase, RT1l, LH1, LHB
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, FSH, HAD, Gonadotropin-Releasing Hormone, ACID
Papers on LH beta
Melatonin replacement restores the circadian behavior in adult rat Leydig cells after pinealectomy.
New
Kostic et al., Novi Sad, Serbia. In Mol Cell Endocrinol, 24 Jul 2015
At hypothalamic-pituitary level, pinealectomy increased mesor of Gnrh, Lhb and rhythm robustness of Mntr1a expression.
Estradiol suppresses neuronal firing activity and c-Fos expression in the lateral habenula.
New
Zhao et al., Changchun, China. In Mol Med Report, 16 Jul 2015
Emerging evidence has revealed that there is an enrichment of cells that express the estrogen receptor in the lateral habenula (LHb) region, however, the precise biological functions of estradiol on neurons in the LHb remain to be elucidated.
Cell Type-Specific Sexual Dimorphism in Pituitary Gene Expression During Maturation.
New
Stojilkovic et al., In Biol Reprod, 10 Jul 2015
Gonadotrophs exhibit highly synchronized Lhb, Fshb, Cga, and Gnrhr expression in both sexes, but the peak of expression occurs during the infantile period in females and at the end of the juvenile period in males.
Ultra-broadband 2D electronic spectroscopy of carotenoid-bacteriochlorophyll interactions in the LH1 complex of a purple bacterium.
New
Cerullo et al., Milano, Italy. In J Chem Phys, 07 Jul 2015
We investigate the excitation energy transfer (EET) pathways in the photosynthetic light harvesting 1 (LH1) complex of purple bacterium Rhodospirillum rubrum with ultra-broadband two-dimensional electronic spectroscopy (2DES).
Effects of the Protonophore Carbonyl-Cyanide m-Chlorophenylhydrazone on Intracytoplasmic Membrane Assembly in Rhodobacter sphaeroides.
New
Niederman et al., United States. In Biochim Biophys Acta, 05 Jul 2015
Proteomic analysis of the chromatophore gel bands indicated that CCCP produced a 2.7-fold reduction in spectral counts in the preferentially assembled light-harvesting 2 (LH2) antenna, while the RC-LH1 complex, F1FO-ATPase and pyridine nucleotide transhydrogenase decreased by 1.7-1.9-fold.
Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.
New
Impact
Malinow et al., San Diego, United States. In Science, Oct 2014
The lateral habenula (LHb), a key regulator of monoaminergic brain regions, is activated by negatively valenced events.
Structure of the LH1-RC complex from Thermochromatium tepidum at 3.0 Å.
New
Impact
Miki et al., Kyoto, Japan. In Nature, May 2014
The light-harvesting core antenna (LH1) and the reaction centre (RC) of purple photosynthetic bacteria form a supramolecular complex (LH1-RC) to use sunlight energy in a highly efficient manner.
The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview.
Review
New
Mameli et al., Paris, France. In Eur J Neurosci, Apr 2014
The lateral habenula (LHb) is an epithalamic region with a crucial role in the regulation of midbrain monoaminergic systems.
Embryonic development of gonadotrope cells and gonadotropic hormones--lessons from model fish.
Review
New
Haug et al., Oslo, Norway. In Mol Cell Endocrinol, Apr 2014
As a means to investigate early functions of FSH and LH in more detail, we have developed a stable transgenic line of medaka with the LH beta subunit gene (lhb) promoter driving green fluorescent protein (Gfp) expression to characterize development of lhb-expressing gonadotropes.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Review
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH.
βCaMKII in lateral habenula mediates core symptoms of depression.
Impact
Hu et al., Shanghai, China. In Science, 2013
The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression.
The medial habenula: still neglected.
Review
Salas et al., Houston, United States. In Front Hum Neurosci, 2012
While the lateral habenula (LHb) has been extensively studied, the anatomically and histochemically distinct medial habenula (MHb) remains largely understudied.
Structural and functional proteomics of intracytoplasmic membrane assembly in Rhodobacter sphaeroides.
Review
Niederman et al., United States. In J Mol Microbiol Biotechnol, 2012
Functional aspects of the photosynthetic unit assembly process were monitored by fluorescence induction/relaxation measurements of the variable fluorescence arising from LH-bacteriochlorophyll a. Slowing of the rate of RC electron transfer turnover (τQA), as assessed from the relaxation phase, was correlated with the growth of the functional absorption cross section (σ) and LH2/LH1 molar ratios.
Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.
GeneRIF
Luján et al., Albacete, Spain. In J Neurochem, 2012
Ca(v) beta(4) protein was detected throughout the developing cerebellum, particularly in the molecular layer, and in contrast to the other subunits, Ca(v) beta(4) was mainly detected in the molecular layer and the hilus of the hippocampus.
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.
GeneRIF
Wondisford et al., Baltimore, United States. In Mol Cell Biol, 2012
CBP may act as a key regulator of LH-beta expression in the gonadotroph by integrating homeostatic information with GNRH signaling.
Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing.
GeneRIF
Matsumoto et al., Yokohama, Japan. In Hum Genet, 2012
Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11, ACTA2 and COL3A1 heterozygous variants were considered as putative pathogenic gene alterations.
Role of luteinizing hormone β-subunit gene variants among South Indian women with polycystic ovary syndrome.
GeneRIF
Reddy et al., Hyderābād, India. In Gene, 2012
We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls
Association between mutations of the luteinizing hormone β subunit and female infertility.
GeneRIF
Qi et al., Huainan, China. In Mol Med Report, 2012
Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women.
Normal spermatogenesis in a man with mutant luteinizing hormone.
Impact
Misrahi et al., Paris, France. In N Engl J Med, 2009
Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells.
Luteinizing hormone beta mutation and hypogonadism in men and women.
Impact
GeneRIF
da Rocha Neves et al., Brasília, Brazil. In N Engl J Med, 2007
homozygous mutation of a 5' splice site in LHB: IVS2+1G-->C disrupts the splicing of messenger RNA, generating a gross abnormality in the processing of the luteinizing hormone beta-subunit mRNA, which abrogates the secretion of luteinizing hormone
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