PACAP, an autocrine/paracrine regulator of gonadotrophs.
Louisville, United States. In Biol Reprod, 2011
PACAP increases alpha-subunit (Cga) and Lhb mRNAs, and it stimulates the transcription of follistatin (Fst) that, in turn, restrains activin signaling to repress Fshb and gonadotropin-releasing hormone-receptor (Gnrhr) expression as well as other activin-responsive genes.
Luteinizing hormone beta mutation and hypogonadism in men and women.
Brasília, Brazil. In N Engl J Med, 2007
homozygous mutation of a 5' splice site in LHB: IVS2+1G-->C disrupts the splicing of messenger RNA, generating a gross abnormality in the processing of the luteinizing hormone beta-subunit mRNA, which abrogates the secretion of luteinizing hormone
The native architecture of a photosynthetic membrane.
Enschede, Netherlands. In Nature, 2004
In the first, groups of 10-20 molecules of LH2 form light-capture domains that interconnect linear arrays of dimers of core reaction centre (RC)-light-harvesting 1 (RC-LH1-PufX) complexes; in the second they were found outside these arrays in larger clusters.
Crystal structure of the RC-LH1 core complex from Rhodopseudomonas palustris.
Glasgow, United Kingdom. In Science, 2004
The crystal structure at 4.8 angstrom resolution of the reaction center-light harvesting 1 (RC-LH1) core complex from Rhodopseudomonas palustris shows the reaction center surrounded by an oval LH1 complex that consists of 15 pairs of transmembrane helical alpha- and beta-apoproteins and their coordinated bacteriochlorophylls. Complete closure of the RC by the LH1 is prevented by a single transmembrane helix, out of register with the array of inner LH1 alpha-apoproteins.
The purple bacterial photosynthetic unit.
In Photosynth Res, 1996
Detailed structural information is now available for not only the reaction center (Lancaster et al. 1995, in: Blankenship RE et al. (eds) Anoxygenic Photosynthetic Bacteria, pp 503-526), but also LH2 from Rhodopseudomonas acidophila (McDermott et al. 1995, Nature 374: 517-521) and LH1 from Rhodospirillum rubrum (Karrasch et al. 1995.