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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Oct 2014.

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

LH beta, lysyl hydroxylase, RT1l, LH1, LHB
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, FSH, HAD, Gonadotropin-Releasing Hormone, ACID
Papers on LH beta
β-catenin stabilization in gonadotropes impairs follicle-stimulating hormone synthesis in male mice in vivo.
New
Bernard et al., Montréal, Canada. In Endocrinology, 24 Nov 2014
UNLABELLED: Though classically considered a WNT signaling intermediary, CTNNB1 (β-catenin) can also mediate GnRH induction of gonadotropin β subunit (Fshb and Lhb) transcription in the murine gonadotrope-like cell line LβT2.
Subtle spectral effects accompanying the assembly of bacteriochlorophylls into cyclic light harvesting complexes revealed by high-resolution fluorescence spectroscopy.
New
Freiberg et al., Tartu, Estonia. In J Chem Phys, 21 Nov 2014
We have observed that an assembly of the bacteriochloropyll a molecules into B850 and B875 groups of cyclic bacterial light-harvesting complexes LH2 and LH1, respectively, results an almost total loss of the intra-molecular vibronic structure in the fluorescence spectrum, and simultaneously, an essential enhancement of its phonon sideband due to electron-phonon coupling.
A time-course transcriptional kinetics of the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in zebrafish eleuthero-embryos after exposure to norgestrel.
New
Peng et al., Guangzhou, China. In Environ Toxicol Chem, 15 Nov 2014
NGT treatment could significantly induce expression of Cyp19a1a, Cyp11b, Gnrh2, Gnrh3 and Lhb mRNAs, but inhibit transcripts of Hsd11b2 and Crh genes above 5 ng L(-1) at different time points.
Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning.
New
Morales et al., Baltimore, United States. In J Neurosci, 15 Nov 2014
Recent findings indicate that VTA GABAergic neurons that coexpress tyrosine hydroxylase (TH) projecting to lateral habenula (LHb) play a role in reward.
Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.
New
Impact
Malinow et al., San Diego, United States. In Science, 19 Oct 2014
The lateral habenula (LHb), a key regulator of monoaminergic brain regions, is activated by negatively valenced events.
Distribution of colored carotenoids between light-harvesting complexes in the process of recovering carotenoid biosynthesis in Ectothiorhodospira haloalkaliphila cells.
New
Moskalenko et al., Pushchino, Russia. In J Photochem Photobiol B, 16 Oct 2014
It has been found that (1) the rate of recovering colored-Car biosynthesis in the lag-phase is far ahead of the growth rate of the cells themselves; (2) several Cars (ζ-carotene, neurosporene etc.) act as intermediates in Car biosynthesis; (3) because filling the "empty" Car pockets in the LH1-RC complexes is faster than in LH2, available spirilloxanthin is preferentially incorporated into the nascent LH1-RC core particles; (4) as a consequence of the resulting lack of spirilloxanthin availability, the biosynthetic intermediates (anhydrorhodovibrin, rhodopin and lycopene) fill the empty nascent LH2 Car pockets.
Structure of the LH1-RC complex from Thermochromatium tepidum at 3.0 Å.
New
Impact
Miki et al., Kyoto, Japan. In Nature, May 2014
The light-harvesting core antenna (LH1) and the reaction centre (RC) of purple photosynthetic bacteria form a supramolecular complex (LH1-RC) to use sunlight energy in a highly efficient manner.
Embryonic development of gonadotrope cells and gonadotropic hormones--lessons from model fish.
Review
New
Haug et al., Oslo, Norway. In Mol Cell Endocrinol, Apr 2014
As a means to investigate early functions of FSH and LH in more detail, we have developed a stable transgenic line of medaka with the LH beta subunit gene (lhb) promoter driving green fluorescent protein (Gfp) expression to characterize development of lhb-expressing gonadotropes.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Review
New
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), Dec 2013
Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH.
Bone collagen: new clues to its mineralization mechanism from recessive osteogenesis imperfecta.
Review
New
Weis et al., Seattle, United States. In Calcif Tissue Int, Oct 2013
They include CRTAP, LEPRE1, and PPIB, which encode three proteins forming the prolyl 3-hydroxylase complex; PLOD2 and FKBP10, which encode, respectively, lysyl hydroxylase 2 and a foldase required for its activity in forming mature cross-links in bone collagen; SERPINH1, which encodes the collagen chaperone HSP47; SERPINF1, which encodes pigment epithelium-derived factor required for osteoid mineralization; and BMP1, which encodes the type I procollagen C-propeptidase.
βCaMKII in lateral habenula mediates core symptoms of depression.
New
Impact
Hu et al., Shanghai, China. In Science, Sep 2013
The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression.
The medial habenula: still neglected.
Review
Salas et al., Houston, United States. In Front Hum Neurosci, 2012
While the lateral habenula (LHb) has been extensively studied, the anatomically and histochemically distinct medial habenula (MHb) remains largely understudied.
Structural and functional proteomics of intracytoplasmic membrane assembly in Rhodobacter sphaeroides.
Review
Niederman et al., United States. In J Mol Microbiol Biotechnol, 2012
Functional aspects of the photosynthetic unit assembly process were monitored by fluorescence induction/relaxation measurements of the variable fluorescence arising from LH-bacteriochlorophyll a. Slowing of the rate of RC electron transfer turnover (τQA), as assessed from the relaxation phase, was correlated with the growth of the functional absorption cross section (σ) and LH2/LH1 molar ratios.
Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.
GeneRIF
Luján et al., Albacete, Spain. In J Neurochem, 2012
Ca(v) beta(4) protein was detected throughout the developing cerebellum, particularly in the molecular layer, and in contrast to the other subunits, Ca(v) beta(4) was mainly detected in the molecular layer and the hilus of the hippocampus.
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.
GeneRIF
Wondisford et al., Baltimore, United States. In Mol Cell Biol, 2012
CBP may act as a key regulator of LH-beta expression in the gonadotroph by integrating homeostatic information with GNRH signaling.
Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing.
GeneRIF
Matsumoto et al., Yokohama, Japan. In Hum Genet, 2012
Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11, ACTA2 and COL3A1 heterozygous variants were considered as putative pathogenic gene alterations.
Role of luteinizing hormone β-subunit gene variants among South Indian women with polycystic ovary syndrome.
GeneRIF
Reddy et al., Hyderābād, India. In Gene, 2012
We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls
Association between mutations of the luteinizing hormone β subunit and female infertility.
GeneRIF
Qi et al., Huainan, China. In Mol Med Report, 2012
Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women.
Normal spermatogenesis in a man with mutant luteinizing hormone.
Impact
Misrahi et al., Paris, France. In N Engl J Med, 2009
Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells.
Luteinizing hormone beta mutation and hypogonadism in men and women.
Impact
GeneRIF
da Rocha Neves et al., Brasília, Brazil. In N Engl J Med, 2007
homozygous mutation of a 5' splice site in LHB: IVS2+1G-->C disrupts the splicing of messenger RNA, generating a gross abnormality in the processing of the luteinizing hormone beta-subunit mRNA, which abrogates the secretion of luteinizing hormone
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