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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

LH beta, lysyl hydroxylase, RT1l, LH1, LHB
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, FSH, HAD, Gonadotropin-Releasing Hormone, FSH beta
Papers on LH beta
Icam5 expression exhibits sex differences in the neonatal pituitary and is regulated by estradiol and bisphenol A.
New
Raetzman et al., Urbana, United States. In Endocrinology, Feb 2016
Through microarray and qRT-PCR analysis of pituitaries at PND1, three genes were differentially expressed between males and females: Lhb, Fshb, and intracellular adhesion molecule-5 (Icam5).
Lateral Hypothalamic Area Glutamatergic Neurons and Their Projections to the Lateral Habenula Regulate Feeding and Reward.
New
Stuber et al., Utrecht, Netherlands. In J Neurosci, Feb 2016
Here, we show that lateral hypothalamic area (LHA) glutamatergic neurons, and their projections to the lateral habenula (LHb), negatively regulate the consumption of palatable food.
Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear.
New
Wang et al., Hangzhou, China. In Nat Neurosci, Feb 2016
We found that the laterodorsal tegmentum (LDT) and lateral habenula (LHb) are specifically activated by the mouse predator odorant trimethylthiazoline (TMT).
Temperature dependent LH1→RC energy transfer in purple bacteria Tch. tepidum with shiftable LH1-Qy band: A natural system to investigate thermally activated energy transfer in photosynthesis.
New
van Grondelle et al., Amsterdam, Netherlands. In Biochim Biophys Acta, Jan 2016
UNASSIGNED: The native LH1-RC complex of the purple bacterium Thermochromatium (Tch.)
Development and dynamics of the photosynthetic apparatus in purple phototrophic bacteria.
Review
New
Niederman, United States. In Biochim Biophys Acta, Nov 2015
AFM imaging studies of the formation of the reaction center (RC)-light harvesting 1 (LH1) complex suggested a cooperative assembly mechanism in which, following the association between the RC template and the initial LH1 unit, addition of successive LH1 units to the RC drives the assembly process to completion.
The spirilloxanthine-pathway carotenoid incorporation into light-harvesting complexes of Ectothiorhodospira haloalkaliphila in vitro.
New
Moskalenko et al., Moscow, Russia. In Dokl Biochem Biophys, Nov 2015
Carotenoidless light-harvesting complexes (DPA-complexes) LH1-RC and LH2 were isolated from the purple sulfur bacterium Ectothiorhodospira haloalkaliphila in which carotenoid biosynthesis was suppressed with diphenylamine (DPA).
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.
New
Impact
Eming et al., Köln, Germany. In Immunity, Nov 2015
We identified Relm-α as one important player in the pathway from IL-4Rα signaling in macrophages to the induction of lysyl hydroxylase 2 (LH2), an enzyme that directs persistent pro-fibrotic collagen cross-links, in fibroblasts.
The role of lateral habenula-dorsal raphe nucleus circuits in higher brain functions and psychiatric illness.
Review
New
Rusak et al., Changchun, China. In Behav Brain Res, Feb 2015
The lateral nucleus of the habenular complex (LHb) is closely connected to the DRN both morphologically and functionally.
Insights into the Role of the Habenular Circadian Clock in Addiction.
Review
Mendoza et al., Strasbourg, France. In Front Psychiatry, 2014
The epithalamic lateral habenula (LHb) is now emerging as a key nucleus in drug intake and addiction.
Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.
Impact
Malinow et al., San Diego, United States. In Science, 2014
The lateral habenula (LHb), a key regulator of monoaminergic brain regions, is activated by negatively valenced events.
Structure of the LH1-RC complex from Thermochromatium tepidum at 3.0 Å.
Impact
Miki et al., Kyoto, Japan. In Nature, 2014
The light-harvesting core antenna (LH1) and the reaction centre (RC) of purple photosynthetic bacteria form a supramolecular complex (LH1-RC) to use sunlight energy in a highly efficient manner.
The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview.
Review
Mameli et al., Paris, France. In Eur J Neurosci, 2014
The lateral habenula (LHb) is an epithalamic region with a crucial role in the regulation of midbrain monoaminergic systems.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Review
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH.
βCaMKII in lateral habenula mediates core symptoms of depression.
Impact
Hu et al., Shanghai, China. In Science, 2013
The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression.
Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.
GeneRIF
Luján et al., Albacete, Spain. In J Neurochem, 2012
Ca(v) beta(4) protein was detected throughout the developing cerebellum, particularly in the molecular layer, and in contrast to the other subunits, Ca(v) beta(4) was mainly detected in the molecular layer and the hilus of the hippocampus.
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.
GeneRIF
Wondisford et al., Baltimore, United States. In Mol Cell Biol, 2012
CBP may act as a key regulator of LH-beta expression in the gonadotroph by integrating homeostatic information with GNRH signaling.
Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing.
GeneRIF
Matsumoto et al., Yokohama, Japan. In Hum Genet, 2012
Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11, ACTA2 and COL3A1 heterozygous variants were considered as putative pathogenic gene alterations.
Role of luteinizing hormone β-subunit gene variants among South Indian women with polycystic ovary syndrome.
GeneRIF
Reddy et al., Hyderābād, India. In Gene, 2012
We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls
Association between mutations of the luteinizing hormone β subunit and female infertility.
GeneRIF
Qi et al., Huainan, China. In Mol Med Report, 2012
Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women.
Normal spermatogenesis in a man with mutant luteinizing hormone.
Impact
Misrahi et al., Paris, France. In N Engl J Med, 2009
Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells.
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