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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 05 Nov 2015.

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

LH beta, lysyl hydroxylase, RT1l, LH1, LHB
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, FSH, HAD, Gonadotropin-Releasing Hormone, FSH beta
Papers on LH beta
Elementary Energy Transfer Pathways in Allochromatium vinosum Photosynthetic Membranes.
Cogdell et al., Madrid, Spain. In Biophys J, 03 Dec 2015
Under low light illumination or low ambient temperature conditions, most of the LH2 complexes in the photosynthetic membranes form a B820 exciton with reduced spectral overlap with LH1.
Combination of Genistein and Cisplatin with Two Designed Monofunctional Platinum Agents in Human Ovarian Tumour Models.
Huq et al., Sydney, Australia. In Anticancer Res, 30 Nov 2015
Herein we report the synthesis of monofunctional platinum tris(3-hydroxypyridine)chloroplatinum(II) chloride (coded as LH1) and tris(imidazole)chloroplatinum(II) chloride (coded as LH2), and their activity alone and in combination with genistein and cisplatin against human ovarian A2780, cisplatin-resistant A2780(cisR) and picoplatin-resistant A2780(ZD0473R) cancer cell lines.
Development and dynamics of the photosynthetic apparatus in purple phototrophic bacteria.
Niederman, United States. In Biochim Biophys Acta, 28 Nov 2015
AFM imaging studies of the formation of the reaction center (RC)-light harvesting 1 (LH1) complex suggested a cooperative assembly mechanism in which, following the association between the RC template and the initial LH1 unit, addition of successive LH1 units to the RC drives the assembly process to completion.
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.
Eming et al., Köln, Germany. In Immunity, 20 Nov 2015
We identified Relm-α as one important player in the pathway from IL-4Rα signaling in macrophages to the induction of lysyl hydroxylase 2 (LH2), an enzyme that directs persistent pro-fibrotic collagen cross-links, in fibroblasts.
The variability of light-harvesting complexes in aerobic anoxygenic phototrophs.
Koblížek et al., Czech Republic. In Photosynth Res, 19 Nov 2015
Three of the studied AAP species did not contain outer light-harvesting complexes, and the size of their reaction center core complexes (RC-LH1 core complexes) varied between 29 and 36 bacteriochlorophyll molecules.
Fshb-iCre mice are efficient and specific Cre deleters for the gonadotrope lineage.
Kumar et al., United States. In Mol Cell Endocrinol, 12 Nov 2015
UNASSIGNED: Genetic analysis of development and function of the gonadotrope cell lineage within mouse anterior pituitary has been greatly facilitated by at least three currently available Cre strains in which Cre was either knocked into the Gnrhr locus or expressed as a transgene from Cga and Lhb promoters.
Serotonin stimulates lateral habenula via activation of the post-synaptic serotonin 2/3 receptors and transient receptor potential channels.
Ye et al., Newark, United States. In Neuropharmacology, 12 Nov 2015
UNASSIGNED: There is growing interest on the role of the lateral habenula (LHb) in depression, because it closely and bilaterally connects with the serotoninergic raphe nuclei.
The role of lateral habenula-dorsal raphe nucleus circuits in higher brain functions and psychiatric illness.
Rusak et al., Changchun, China. In Behav Brain Res, Feb 2015
The lateral nucleus of the habenular complex (LHb) is closely connected to the DRN both morphologically and functionally.
Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.
Malinow et al., San Diego, United States. In Science, Oct 2014
The lateral habenula (LHb), a key regulator of monoaminergic brain regions, is activated by negatively valenced events.
Structure of the LH1-RC complex from Thermochromatium tepidum at 3.0 Å.
Miki et al., Kyoto, Japan. In Nature, May 2014
The light-harvesting core antenna (LH1) and the reaction centre (RC) of purple photosynthetic bacteria form a supramolecular complex (LH1-RC) to use sunlight energy in a highly efficient manner.
The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview.
Mameli et al., Paris, France. In Eur J Neurosci, Apr 2014
The lateral habenula (LHb) is an epithalamic region with a crucial role in the regulation of midbrain monoaminergic systems.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH.
βCaMKII in lateral habenula mediates core symptoms of depression.
Hu et al., Shanghai, China. In Science, 2013
The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression.
The medial habenula: still neglected.
Salas et al., Houston, United States. In Front Hum Neurosci, 2012
While the lateral habenula (LHb) has been extensively studied, the anatomically and histochemically distinct medial habenula (MHb) remains largely understudied.
Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.
Luján et al., Albacete, Spain. In J Neurochem, 2012
Ca(v) beta(4) protein was detected throughout the developing cerebellum, particularly in the molecular layer, and in contrast to the other subunits, Ca(v) beta(4) was mainly detected in the molecular layer and the hilus of the hippocampus.
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.
Wondisford et al., Baltimore, United States. In Mol Cell Biol, 2012
CBP may act as a key regulator of LH-beta expression in the gonadotroph by integrating homeostatic information with GNRH signaling.
Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing.
Matsumoto et al., Yokohama, Japan. In Hum Genet, 2012
Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11, ACTA2 and COL3A1 heterozygous variants were considered as putative pathogenic gene alterations.
Role of luteinizing hormone β-subunit gene variants among South Indian women with polycystic ovary syndrome.
Reddy et al., Hyderābād, India. In Gene, 2012
We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls
Association between mutations of the luteinizing hormone β subunit and female infertility.
Qi et al., Huainan, China. In Mol Med Report, 2012
Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women.
Normal spermatogenesis in a man with mutant luteinizing hormone.
Misrahi et al., Paris, France. In N Engl J Med, 2009
Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells.
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