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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

LH beta, lysyl hydroxylase, RT1l, LH1, LHB
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FSH, CAN, HAD, Gonadotropin-Releasing Hormone, ACID
Papers on LH beta
Structure of the LH1-RC complex from Thermochromatium tepidum at 3.0 Å
New
Impact
Miki et al., Kyoto, Japan. In Nature, 26 Apr 2014
UNLABELLED: The light-harvesting core antenna (LH1) and the reaction centre (RC) of purple photosynthetic bacteria form a supramolecular complex (LH1-RC) to use sunlight energy in a highly efficient manner.
Versatile design of biohybrid light-harvesting architectures to tune location, density, and spectral coverage of attached synthetic chromophores for enhanced energy capture.
New
Parkes-Loach et al., Saint Louis, United States. In Photosynth Res, 07 Apr 2014
All chromophore-polypeptides readily formed LH1-type complexes upon combination with the α-polypeptide and BChl a. Efficient energy transfer occurs from the attached chromophore to the circular array of 875 nm absorbing BChl a molecules (denoted B875).
Effects of diethylstilbestrol on luteinizing hormone-producing cells in the mouse anterior pituitary.
New
Sato et al., Yokohama, Japan. In Exp Biol Med (maywood), 01 Apr 2014
The expression of the LH beta (Lhb) subunit in the anterior pituitary of 90-day-old neoDES females was similar to that in neoOil females, but it was significantly lower than that observed in 90-day-old males.
JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation.
New
Shang et al., Beijing, China. In Plos Biol, 31 Mar 2014
We demonstrated that JMJD6 acts as an α-ketoglutarate- and Fe(II)-dependent lysyl hydroxylase to catalyze p53 hydroxylation.
Integration of energy and electron transfer processes in the photosynthetic membrane of Rhodobacter sphaeroides.
New
Neil Hunter et al., Sheffield, United Kingdom. In Biochim Biophys Acta, 12 Mar 2014
The cytbc1 complexes appeared to be adjacent to reaction centre light-harvesting 1-PufX (RC-LH1-PufX) complexes, consistent with AFM topographs of a gold-labelled membrane.
Interleukin-1β Attenuates Myofibroblast Formation and Extracellular Matrix Production in Dermal and Lung Fibroblasts Exposed to Transforming Growth Factor-β1.
New
Bank et al., Groningen, Netherlands. In Plos One, Dec 2013
Using lung and dermal fibroblasts, we have investigated the effects of IL1β, TGFβ1, and IL1β in combination with TGFβ1 on myofibroblast formation, collagen synthesis and collagen modification (including prolyl hydroxylase, lysyl hydroxylase and lysyl oxidase), and matrix metalloproteinases (MMPs).
Embryonic development of gonadotrope cells and gonadotropic hormones - Lessons from model fish.
Review
New
Haug et al., Oslo, Norway. In Mol Cell Endocrinol, Nov 2013
As a means to investigate early functions of FSH and LH in more detail, we have developed a stable transgenic line of medaka with the LH beta subunit gene (lhb) promoter driving green fluorescent protein (Gfp) expression to characterize development of lhb-expressing gonadotropes.
βCaMKII in lateral habenula mediates core symptoms of depression.
New
Impact
Hu et al., Shanghai, China. In Science, Sep 2013
The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression.
DREADDing the lateral habenula: a review of methodological approaches for studying lateral habenula function.
Review
New
Neumaier et al., Seattle, United States. In Brain Res, Jun 2013
The lateral habenula (LHb) is part of the habenular complex in the dorsal diencephalon.
Structural and functional proteomics of intracytoplasmic membrane assembly in Rhodobacter sphaeroides.
Review
Niederman et al., United States. In J Mol Microbiol Biotechnol, 2012
Functional aspects of the photosynthetic unit assembly process were monitored by fluorescence induction/relaxation measurements of the variable fluorescence arising from LH-bacteriochlorophyll a. Slowing of the rate of RC electron transfer turnover (τQA), as assessed from the relaxation phase, was correlated with the growth of the functional absorption cross section (σ) and LH2/LH1 molar ratios.
The medial habenula: still neglected.
Review
Salas et al., Houston, United States. In Front Hum Neurosci, 2012
While the lateral habenula (LHb) has been extensively studied, the anatomically and histochemically distinct medial habenula (MHb) remains largely understudied.
Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.
GeneRIF
Luján et al., Albacete, Spain. In J Neurochem, 2012
Ca(v) beta(4) protein was detected throughout the developing cerebellum, particularly in the molecular layer, and in contrast to the other subunits, Ca(v) beta(4) was mainly detected in the molecular layer and the hilus of the hippocampus.
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.
GeneRIF
Wondisford et al., Baltimore, United States. In Mol Cell Biol, 2012
CBP may act as a key regulator of LH-beta expression in the gonadotroph by integrating homeostatic information with GNRH signaling.
Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing.
GeneRIF
Matsumoto et al., Yokohama, Japan. In Hum Genet, 2012
Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11, ACTA2 and COL3A1 heterozygous variants were considered as putative pathogenic gene alterations.
Role of luteinizing hormone β-subunit gene variants among South Indian women with polycystic ovary syndrome.
GeneRIF
Reddy et al., Hyderābād, India. In Gene, 2012
We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls
Association between mutations of the luteinizing hormone β subunit and female infertility.
GeneRIF
Qi et al., Huainan, China. In Mol Med Report, 2012
Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women.
[Mutations of noncollagen genes in osteogenesis imperfecta--implications of the gene products in collagen biosynthesis and pathogenesis of disease].
Review
Galicka, In Postepy Hig Med Dosw (online), 2011
Mutations in genes that encode proteins involved in collagen prolyl 3-hydroxylation (P3H1/CRTAP/CyPB) eliminated Pro986 hydroxylation and caused an increase in modification of collagen helix by prolyl 4-hydroxylase and lysyl hydroxylase.
Normal spermatogenesis in a man with mutant luteinizing hormone.
Impact
Misrahi et al., Paris, France. In N Engl J Med, 2009
Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells.
Luteinizing hormone beta mutation and hypogonadism in men and women.
Impact
GeneRIF
da Rocha Neves et al., Brasília, Brazil. In N Engl J Med, 2007
homozygous mutation of a 5' splice site in LHB: IVS2+1G-->C disrupts the splicing of messenger RNA, generating a gross abnormality in the processing of the luteinizing hormone beta-subunit mRNA, which abrogates the secretion of luteinizing hormone
The native architecture of a photosynthetic membrane.
Impact
Hunter et al., Enschede, Netherlands. In Nature, 2004
In the first, groups of 10-20 molecules of LH2 form light-capture domains that interconnect linear arrays of dimers of core reaction centre (RC)-light-harvesting 1 (RC-LH1-PufX) complexes; in the second they were found outside these arrays in larger clusters.
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