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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 22 Aug 2015.

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

LH beta, lysyl hydroxylase, RT1l, LH1, LHB
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, FSH, HAD, Gonadotropin-Releasing Hormone, ACID
Papers on LH beta
ISL1 is necessary for maximal thyrotrope response to hypothyroidism.
New
Camper et al., Ann Arbor, United States. In Mol Endocrinol, 21 Sep 2015
In contrast, deletion of Isl1 in gonadotropes with an Lhb-cre transgene has no obvious effect on gonadotrope function or fertility.
Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons.
New
Ye et al., Newark, United States. In Addict Biol, 18 Sep 2015
UNASSIGNED: There has been increasing interest in the lateral habenula (LHb) given its potent regulatory role in many aversion-related behaviors.
[Rhodobaculum claviforme gen. nov., sp. nov., a New Alkaliphilic Nonsulfur Purple Bacterium].
New
Gorlenko et al., In Mikrobiologiia, Mar 2015
The photosynthetic apparatus was represented by LH2 and LH1 light-harvesting complexes.
Integrated miRNA-mRNA analysis in the habenula nuclei of mice intravenously self-administering nicotine.
New
Im et al., Seoul, South Korea. In Sci Rep, Dec 2014
Habenula (Hb), one of the critical brain regions involved in reward and addiction, can be divided into two anatomically and transcriptionally distinct regions: medial habenula (MHb) and lateral habenula (LHb) nuclei.
Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.
New
Impact
Malinow et al., San Diego, United States. In Science, Oct 2014
The lateral habenula (LHb), a key regulator of monoaminergic brain regions, is activated by negatively valenced events.
Structure of the LH1-RC complex from Thermochromatium tepidum at 3.0 Å.
New
Impact
Miki et al., Kyoto, Japan. In Nature, May 2014
The light-harvesting core antenna (LH1) and the reaction centre (RC) of purple photosynthetic bacteria form a supramolecular complex (LH1-RC) to use sunlight energy in a highly efficient manner.
The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview.
Review
New
Mameli et al., Paris, France. In Eur J Neurosci, Apr 2014
The lateral habenula (LHb) is an epithalamic region with a crucial role in the regulation of midbrain monoaminergic systems.
Embryonic development of gonadotrope cells and gonadotropic hormones--lessons from model fish.
Review
New
Haug et al., Oslo, Norway. In Mol Cell Endocrinol, Apr 2014
As a means to investigate early functions of FSH and LH in more detail, we have developed a stable transgenic line of medaka with the LH beta subunit gene (lhb) promoter driving green fluorescent protein (Gfp) expression to characterize development of lhb-expressing gonadotropes.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Review
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH.
βCaMKII in lateral habenula mediates core symptoms of depression.
Impact
Hu et al., Shanghai, China. In Science, 2013
The lateral habenula (LHb) has recently emerged as a key brain region in the pathophysiology of depression.
Electron Conduction and Photocurrent Generation of a Light-Harvesting/Reaction Center Core Complex in Lipid Membrane Environments.
Nango et al., Nagoya, Japan. In J Phys Chem Lett, 2013
In this study, the electron conductivity and photocurrent of a light-harvesting/reaction center core complex (LH1-RC) embedded in a lipid membrane were measured using conductive atomic force microscopy (C-AFM) and photoelectrochemical analysis.
The medial habenula: still neglected.
Review
Salas et al., Houston, United States. In Front Hum Neurosci, 2012
While the lateral habenula (LHb) has been extensively studied, the anatomically and histochemically distinct medial habenula (MHb) remains largely understudied.
Structural and functional proteomics of intracytoplasmic membrane assembly in Rhodobacter sphaeroides.
Review
Niederman et al., United States. In J Mol Microbiol Biotechnol, 2012
Functional aspects of the photosynthetic unit assembly process were monitored by fluorescence induction/relaxation measurements of the variable fluorescence arising from LH-bacteriochlorophyll a. Slowing of the rate of RC electron transfer turnover (τQA), as assessed from the relaxation phase, was correlated with the growth of the functional absorption cross section (σ) and LH2/LH1 molar ratios.
Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.
GeneRIF
Luján et al., Albacete, Spain. In J Neurochem, 2012
Ca(v) beta(4) protein was detected throughout the developing cerebellum, particularly in the molecular layer, and in contrast to the other subunits, Ca(v) beta(4) was mainly detected in the molecular layer and the hilus of the hippocampus.
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.
GeneRIF
Wondisford et al., Baltimore, United States. In Mol Cell Biol, 2012
CBP may act as a key regulator of LH-beta expression in the gonadotroph by integrating homeostatic information with GNRH signaling.
Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing.
GeneRIF
Matsumoto et al., Yokohama, Japan. In Hum Genet, 2012
Data show that homozygous and compound heterozygous changes found in PLOD1 and SLC2A10 may confer autosomal recessive effects, and three MYH11, ACTA2 and COL3A1 heterozygous variants were considered as putative pathogenic gene alterations.
Role of luteinizing hormone β-subunit gene variants among South Indian women with polycystic ovary syndrome.
GeneRIF
Reddy et al., Hyderābād, India. In Gene, 2012
We identified seven SNPs in the LH beta gene; one SNP in exon 3 (rs#1056917) exhibited significant difference in the allele frequency between the PCOS cases and controls
Association between mutations of the luteinizing hormone β subunit and female infertility.
GeneRIF
Qi et al., Huainan, China. In Mol Med Report, 2012
Polymorphisms of Trp8Arg and Ile15Thr in the LH-beta subunit gene occur in infertile women.
Normal spermatogenesis in a man with mutant luteinizing hormone.
Impact
Misrahi et al., Paris, France. In N Engl J Med, 2009
Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells.
Luteinizing hormone beta mutation and hypogonadism in men and women.
Impact
GeneRIF
da Rocha Neves et al., Brasília, Brazil. In N Engl J Med, 2007
homozygous mutation of a 5' splice site in LHB: IVS2+1G-->C disrupts the splicing of messenger RNA, generating a gross abnormality in the processing of the luteinizing hormone beta-subunit mRNA, which abrogates the secretion of luteinizing hormone
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