Endometrial LGR7 expression and implantation failure.
Napoli, Italy. In Gynecol Endocrinol, Feb 2016
In a prospective observational study, the endometrial RLX receptor (LGR7) expression was assessed in three groups of patients with regular ovulatory cycle and normal uterine cavity: 23 with RPL (Group A), 23 with unexplained infertility undergone at least three cycles of failed in vitro fertilization (IVF) reporting good oocyte and embryo quality (Group B), 23 with proven fertility (Group C).
Relaxin family peptides and their receptors.
Australia. In Physiol Rev, 2013
Although they are structurally related to insulin, the relaxin family peptides produce their physiological effects by activating a group of four G protein-coupled receptors (GPCRs), relaxin family peptide receptors 1-4 (RXFP1-4).
Endometrial LGR7 expression during menstrual cycle.
Napoli, Italy. In Fertil Steril, 2011
LGR7 is constitutively expressed in human endometrium, and an increased LGR7 immunostaining is demonstrated in the secretory phase, confirming the involvement of relaxin in the physiology of endometrium and suggesting its role in implantation.