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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Leucine-rich repeat containing G protein-coupled receptor 5

Lgr5, GPR49
Top mentioned proteins: CAN, CD44, HAD, LGR4, HAIR
Papers using Lgr5 antibodies
Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiation.
Schneider Marlon R., In PLoS ONE, 2006
... or rabbit polyclonal, 1979-1, Epitomics, Burlingame, CA), S100A3 (rabbit polyclonal, 12343-1-AP, ProteinTech Group, Chicago, IL), LGR5 (rabbit polyclonal, AP2745f, Abgent, San Diego, CA), Glyceraldehyde-3-phosphate ...
Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer.
Defossez Pierre-Antoine, In PLoS ONE, 2006
... Antibodies used in this study were: anti-LGR5 N-terminal region Sigma Prestige HPA012530 (Sigma, St.Louis, MO); anti-LGR5 central region, AP2745f (Abgent, SanDiego, CA); anti E-cadherin ...
Papers on Lgr5
Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity.
Watt et al., London, United Kingdom. In Cell Rep, Feb 2016
LGR6(+) and LRIG1(+) stem cells contributed to ectopic hair follicles formed in the sebaceous gland upon β-catenin activation, whereas LGR5(+) cells did not.
What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue.
Letellier et al., Luxembourg, Luxembourg. In Plos One, Dec 2015
Primary SC express key stemness proteins such as SOX2, OCT4, NANOG and LGR5 and importantly show increased chemoresistance ability compared to their adherent differentiated counterparts and to cell line-derived SC.
Expression and clinical significance of SALL4 and LGR5 in patients with lung cancer.
Mo et al., Guilin, China. In Oncol Lett, Dec 2015
The purpose of the present study is to investigate the expression and clinical significance of the stem cell-associated markers Sal-like protein 4 (SALL4) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) in lung cancer, and to provide novel diagnostic markers and targets for the treatment of lung cancer.
A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors.
Passier et al., Leiden, Netherlands. In Sci Rep, Dec 2015
Finally, we identified cell surface markers for cardiac progenitors, such as the Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), belonging to the same subfamily of LGR5, and LGR6, established tissue/cancer stem cells markers.
Cancer stem cells in human digestive tract malignancies.
Saeinasab et al., Mashhad, Iran. In Tumour Biol, Nov 2015
For instance, identification of markers associated with digestive tract CSCs, such as CD44, CD133, CD24, EpCAM, LGR5, ALDH1, and BMI1, has made it possible to develop more accurate diagnosis approaches.
Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma.
Underwood et al., Southampton, United Kingdom. In Br J Cancer, Jul 2015
Nine molecules had been examined in more than one study (CD3, CD8, COX-2, EGFR, HER2, Ki67, LgR5, p53 and VEGF) and were meta-analysed.
Clinical implications of intestinal stem cell markers in colorectal cancer.
Troelsen et al., Denmark. In Clin Colorectal Cancer, Jun 2015
This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell-specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC.
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.
Wells et al., Cincinnati, United States. In Nature, 2015
Organoids formed primitive gastric gland- and pit-like domains, proliferative zones containing LGR5-expressing cells, surface and antral mucous cells, and a diversity of gastric endocrine cells.
Stem Cell Markers in Neuroblastoma-An Emerging Role for LGR5.
Carr-Wilkinson et al., Sunderland, United Kingdom. In Front Cell Dev Biol, 2014
Our findings show that the stem cell marker Lgr5 is associated with an aggressive phenotype in neuroblastoma.
Extracellular modulators of Wnt signalling.
Jones et al., United States. In Curr Opin Struct Biol, 2014
Structures include Wnt in complex with the cysteine-rich domain (CRD) of Frizzled, extracellular fragments of Wnt co-receptor LRP6, LRP6-binding antagonists Dickkopf and Sclerostin, antagonists 5T4/WAIF1 and Wnt inhibitory factor 1 (WIF-1), as well as Frizzled-ubiquitin ligases ZNRF3/RNF43 (in isolation and in complexes with Wnt signalling promoters R-spondins and LGR5).
Overexpression of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 (LGR5) Represents a Typical Wnt/β-Catenin Pathway-Activated Hepatocellular Carcinoma.
Sakamoto et al., Tokyo, Japan. In Liver Cancer, 2014
We previously identified overexpression of the leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), also known as GPR49, in HCC with β-catenin mutations.
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.
Batlle et al., Barcelona, Spain. In Nat Cell Biol, 2014
GATA6 directly drives the expression of LGR5 in adenoma stem cells whereas it restricts BMP signalling to differentiated tumour cells.
Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.
Shivdasani et al., Boston, United States. In Nature, 2014
Transcript profiles in isolated LGR5(+) intestinal stem cells and secretory and absorptive progenitors indicated that each cell population was distinct and the progenitors specified.
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.
Sansom et al., Glasgow, United Kingdom. In Cell Stem Cell, 2013
We find that RAC1 is required for expansion of the LGR5 intestinal stem cell (ISC) signature, progenitor hyperproliferation, and transformation.
Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche.
Nikitin et al., Ithaca, United States. In Nature, 2013
We find that cells of the hilum OSE are cycling slowly and express stem and/or progenitor cell markers ALDH1, LGR5, LEF1, CD133 and CK6B.
CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice.
Henning et al., Chapel Hill, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
CD24-based sorting in wild-type mice isolates a colonic epithelial fraction highly enriched in actively cycling and quiescent Lgr5 positive putative colonic epithelial stem cells.
Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea.
Edge et al., Boston, United States. In J Neurosci, 2012
This study showed here that Lgr5, a marker for adult stem cells, was expressed in a subset of supporting cells in the newborn and adult murine cochlea
LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling.
Liu et al., Houston, United States. In Mol Cell Biol, 2012
LGR5 is a part of the Wnt signaling complex at the membrane level to enhance Wnt/beta-catenin signaling. However, internalization of LGR5 does not appear to be essential for potentiating the canonical Wnt signaling pathway.
Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells.
Shivdasani et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Lgr5 receptor-expressing intestinal stem cells function in the absence of Paneth cells
The spatial distribution of LGR5+ cells correlates with gastric cancer progression.
Röcken et al., Kiel, Germany. In Plos One, 2011
LGR5 is differentially expressed in gastrointestinal cancers and that the spatial histoanatomical distribution of LGR5(+) cells has to be considered when their tumour biological significance is sought.
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