Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiation.
In PLoS ONE, 2006
... or rabbit polyclonal, 1979-1, Epitomics, Burlingame, CA), S100A3 (rabbit polyclonal, 12343-1-AP, ProteinTech Group, Chicago, IL), LGR5 (rabbit polyclonal, AP2745f, Abgent, San Diego, CA), Glyceraldehyde-3-phosphate ...
Expression and clinical significance of SALL4 and LGR5 in patients with lung cancer.
Guilin, China. In Oncol Lett, Dec 2015
The purpose of the present study is to investigate the expression and clinical significance of the stem cell-associated markers Sal-like protein 4 (SALL4) and leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) in lung cancer, and to provide novel diagnostic markers and targets for the treatment of lung cancer.
Cancer stem cells in human digestive tract malignancies.
Mashhad, Iran. In Tumour Biol, Nov 2015
For instance, identification of markers associated with digestive tract CSCs, such as CD44, CD133, CD24, EpCAM, LGR5, ALDH1, and BMI1, has made it possible to develop more accurate diagnosis approaches.
Clinical implications of intestinal stem cell markers in colorectal cancer.
Denmark. In Clin Colorectal Cancer, Jun 2015
This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell-specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC.
Extracellular modulators of Wnt signalling.
United States. In Curr Opin Struct Biol, 2014
Structures include Wnt in complex with the cysteine-rich domain (CRD) of Frizzled, extracellular fragments of Wnt co-receptor LRP6, LRP6-binding antagonists Dickkopf and Sclerostin, antagonists 5T4/WAIF1 and Wnt inhibitory factor 1 (WIF-1), as well as Frizzled-ubiquitin ligases ZNRF3/RNF43 (in isolation and in complexes with Wnt signalling promoters R-spondins and LGR5).