R-spondins/Lgrs expression in tooth development.
London, United Kingdom. In Dev Dyn, Jun 2014
The members of the R-spondin family are known as activators of Wnt signaling, and Lgr4, Lgr5, and Lgr6 have been identified as receptors for R-spondins.
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
Houston, United States. In Proc Natl Acad Sci U S A, May 2014
R-spondins (RSPOs) and their receptor leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) play pleiotropic roles in normal and cancer development as well as the survival of adult stem cells through potentiation of Wnt signaling.
Wakayama Symposium: Epithelial-mesenchymal interactions in eyelid development.
Okayama, Japan. In Ocul Surf, 2012
These include FGFR2b-FGF10, EGFR-ERK, MEKK-JNK, BMP, Shh, Wnt, GPR48, Jun, Forkhead, and Grainyhead.