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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Nov 2015.

Leucine-rich repeat-containing G protein-coupled receptor 4

LGR4, GPR48, G protein-coupled receptor 48
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008] (from NCBI)
Top mentioned proteins: Lgr5, V1a, GPCR, CAN, HAD
Papers on LGR4
Lgr4 Controls Specialization of Female Gonads in Mice.
Nishimori et al., Japan. In Biol Reprod, 31 Oct 2015
Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is a type of membrane receptor with a seven-transmembrane structure.
BMP-2 Enhances Lgr4 Gene Expression in Osteoblastic Cells.
Noda et al., Tokyo, Japan. In J Cell Physiol, 02 Oct 2015
Lgr4 gene encodes an orphan receptor and has been identified as a genetic determinant for bone mass in osteoporotic patients.
Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/Sirt1/Pgc1α pathway.
Ning et al., Shanghai, China. In Biochem Biophys Res Commun, Sep 2015
Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is a newfound obese-associated gene.
Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
Jones et al., Oxford, United Kingdom. In J Struct Biol, Aug 2015
Rspo proteins act by cross-linking members of two cell surface receptor families, complexing the stem cell markers LGR4-6 with the Frizzled-specific E3 ubiquitin ligases ZNRF3/RNF43.
Molecular Characterization of FZD4, LRP5, and TSPAN12 in Familial Exudative Vitreoretinopathy.
Kim et al., Seoul, South Korea. In Invest Ophthalmol Vis Sci, Aug 2015
In patients with no mutation detected, sequencing analyses for ZNF408, a novel gene potentially related to FEVR, and two other genes related to retinal development, LGR4 and ATOH7, were performed.
LGR4 and Its Role in Intestinal Protection and Energy Metabolism.
Mulholland et al., Ann Arbor, United States. In Front Endocrinol (lausanne), Dec 2014
Distinct from classical G protein-coupled receptors which act via G proteins, LGR4 functions mainly through Wnt/β-catenin signaling to regulate cell proliferation, differentiation, and adult stem cell homeostasis.
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Schiöth et al., Uppsala, Sweden. In Genome Med, Dec 2014
Out of 107 CpG sites, 38 are located in gene promoters, including genes strongly implicated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1, SH2B1, ATXN2L, and IL27).
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.
Clevers et al., Utrecht, Netherlands. In Genes Dev, Mar 2014
Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors.
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.
Ning et al., Shanghai, China. In Nat Cell Biol, 2013
Here, we show that Lgr4 homozygous mutant (Lgr4(m/m)) mice show reduced adiposity and resist dietary and leptin mutant-induced obesity with improved glucose metabolism.
Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells.
Goidts et al., Nagoya, Japan. In Cancer Manag Res, 2013
Recent studies have indicated that leucine-rich repeat-containing G-protein-coupled receptor 4 and 5 (LGR4 and LGR5) expression in multiple organs may represent a global marker of adult stem cells.
[Ways to personalized medicine for gastric cancer].
Röcken, Kiel, Germany. In Pathologe, 2013
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.
Stefansson et al., Reykjavík, Iceland. In Nature, 2013
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.
Wakayama Symposium: Epithelial-mesenchymal interactions in eyelid development.
Ohuchi, Okayama, Japan. In Ocul Surf, 2012
These include FGFR2b-FGF10, EGFR-ERK, MEKK-JNK, BMP, Shh, Wnt, GPR48, Jun, Forkhead, and Grainyhead.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Cong et al., Cambridge, United States. In Nature, 2012
Mechanistically, R-spondin interacts with the extracellular domain of ZNRF3 and induces the association between ZNRF3 and LGR4, which results in membrane clearance of ZNRF3.
GPR48 increases mineralocorticoid receptor gene expression.
Ning et al., Shanghai, China. In J Am Soc Nephrol, 2012
GPR48 enhances aldosterone responsiveness by activating mineralocorticoid receptor expression.
LGR4 is required for the cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
Nishimori et al., Sendai, Japan. In Biosci Biotechnol Biochem, 2011
LGR4 is required for cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Clevers et al., Utrecht, Netherlands. In Nature, 2011
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments.
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Liu et al., Houston, United States. In Proc Natl Acad Sci U S A, 2011
LGR4 and LGR5 bind the R-spondins with high affinity and mediate the potentiation of Wnt/beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation.
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo.
Garcia et al., Brussels, Belgium. In Embo Rep, 2011
Our results identify LGR4 as a permissive factor in the Wnt pathway in the intestine
Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.
Nishimori et al., Sendai, Japan. In Dev Dyn, 2011
Lgr4 has a novel function for maintaining the ureteric bud in an undifferentiated state.
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