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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Leucine-rich repeat-containing G protein-coupled receptor 4

LGR4, GPR48, G protein-coupled receptor 48
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008] (from NCBI)
Top mentioned proteins: Lgr5, V1a, GPCR, CAN, HAD
Papers on LGR4
A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors.
New
Passier et al., Leiden, Netherlands. In Sci Rep, 31 Dec 2015
Finally, we identified cell surface markers for cardiac progenitors, such as the Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), belonging to the same subfamily of LGR5, and LGR6, established tissue/cancer stem cells markers.
[Research progress of Lgr4 in gastrointestinal carcinomas].
New
Chen et al., Beijing, China. In Zhonghua Wei Chang Wai Ke Za Zhi, 25 Dec 2015
Studies have shown that the expression level of Lgr4 is high in gastrointestinal carcinomas and Lgr4 is useful in diagnosis, differential diagnosis and prognosis judgment of these carcinomas.
Lgr4 controls specialization of female gonads in mice.
New
Nishimori et al., Japan. In Biol Reprod, Oct 2015
Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is a type of membrane receptor with a seven-transmembrane structure.
BMP-2 Enhances Lgr4 Gene Expression in Osteoblastic Cells.
New
Noda et al., Tokyo, Japan. In J Cell Physiol, Oct 2015
Lgr4 gene encodes an orphan receptor and has been identified as a genetic determinant for bone mass in osteoporotic patients.
Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/Sirt1/Pgc1α pathway.
New
Ning et al., Shanghai, China. In Biochem Biophys Res Commun, Sep 2015
Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is a newfound obese-associated gene.
Molecular Characterization of FZD4, LRP5, and TSPAN12 in Familial Exudative Vitreoretinopathy.
New
Kim et al., Seoul, South Korea. In Invest Ophthalmol Vis Sci, Aug 2015
In patients with no mutation detected, sequencing analyses for ZNF408, a novel gene potentially related to FEVR, and two other genes related to retinal development, LGR4 and ATOH7, were performed.
Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
New
Jones et al., Oxford, United Kingdom. In J Struct Biol, Aug 2015
Rspo proteins act by cross-linking members of two cell surface receptor families, complexing the stem cell markers LGR4-6 with the Frizzled-specific E3 ubiquitin ligases ZNRF3/RNF43.
Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.
New
Caron et al., Durham, United States. In J Cell Sci, Apr 2015
We provide here a mechanism whereby the stem-cell marker Lgr5, and its family member Lgr4, promote the formation of cytonemes.
Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation.
Qu et al., Wenzhou, China. In Plos One, 2014
The leucine rich repeat containing G protein-coupled receptor 4 (LGR4, also known as GPR48), is important in many developmental processes.
LGR4 and Its Role in Intestinal Protection and Energy Metabolism.
Mulholland et al., Ann Arbor, United States. In Front Endocrinol (lausanne), 2014
Distinct from classical G protein-coupled receptors which act via G proteins, LGR4 functions mainly through Wnt/β-catenin signaling to regulate cell proliferation, differentiation, and adult stem cell homeostasis.
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Schiöth et al., Uppsala, Sweden. In Genome Med, 2014
Out of 107 CpG sites, 38 are located in gene promoters, including genes strongly implicated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1, SH2B1, ATXN2L, and IL27).
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.
Impact
Ning et al., Shanghai, China. In Nat Cell Biol, 2013
Here, we show that Lgr4 homozygous mutant (Lgr4(m/m)) mice show reduced adiposity and resist dietary and leptin mutant-induced obesity with improved glucose metabolism.
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.
Impact
Stefansson et al., Reykjavík, Iceland. In Nature, 2013
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Impact
Cong et al., Cambridge, United States. In Nature, 2012
Mechanistically, R-spondin interacts with the extracellular domain of ZNRF3 and induces the association between ZNRF3 and LGR4, which results in membrane clearance of ZNRF3.
GPR48 increases mineralocorticoid receptor gene expression.
GeneRIF
Ning et al., Shanghai, China. In J Am Soc Nephrol, 2012
GPR48 enhances aldosterone responsiveness by activating mineralocorticoid receptor expression.
LGR4 is required for the cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
GeneRIF
Nishimori et al., Sendai, Japan. In Biosci Biotechnol Biochem, 2011
LGR4 is required for cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Impact
Clevers et al., Utrecht, Netherlands. In Nature, 2011
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments.
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
GeneRIF
Liu et al., Houston, United States. In Proc Natl Acad Sci U S A, 2011
LGR4 and LGR5 bind the R-spondins with high affinity and mediate the potentiation of Wnt/beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation.
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo.
GeneRIF
Garcia et al., Brussels, Belgium. In Embo Rep, 2011
Our results identify LGR4 as a permissive factor in the Wnt pathway in the intestine
Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.
GeneRIF
Nishimori et al., Sendai, Japan. In Dev Dyn, 2011
Lgr4 has a novel function for maintaining the ureteric bud in an undifferentiated state.
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