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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 03 Oct 2014.

Leucine-rich repeat-containing G protein-coupled receptor 4

LGR4, GPR48, G protein-coupled receptor 48
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008] (from NCBI)
Top mentioned proteins: Lgr5, CAN, GPCR, HAD, V1a
Papers on LGR4
R-spondins/Lgrs expression in tooth development.
New
Ohazama et al., London, United Kingdom. In Dev Dyn, Jun 2014
The members of the R-spondin family are known as activators of Wnt signaling, and Lgr4, Lgr5, and Lgr6 have been identified as receptors for R-spondins.
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
New
Liu et al., Houston, United States. In Proc Natl Acad Sci U S A, May 2014
R-spondins (RSPOs) and their receptor leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) play pleiotropic roles in normal and cancer development as well as the survival of adult stem cells through potentiation of Wnt signaling.
LGR4 acts as a link between the peripheral circadian clock and lipid metabolism in liver.
New
Ning et al., Houston, United States. In J Mol Endocrinol, Apr 2014
In this study, we showed that Lgr4 homozygous mutant (Lgr4(m/m)) mice showed alteration in the rhythms of the respiratory exchange ratio.
LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects.
New
Liu et al., Houston, United States. In J Biol Chem, Apr 2014
In this study we provide evidence that LGR4 (also named GPR48), the only G-protein-coupled receptor gene in the human chromosome 11p12-11p14.4
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.
New
Clevers et al., Utrecht, Netherlands. In Genes Dev, Mar 2014
Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors.
LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats.
New
Mulholland et al., Ann Arbor, United States. In Endocrinology, Feb 2014
Analysis of microarray data derived from ARC revealed that leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) is highly expressed.
Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis.
New
Yoon et al., West Scarborough, United States. In Mol Cell Biol, Feb 2014
Herein, we show that depletion of the LGR4 receptor severely disrupts myogenic differentiation and significantly diminishes the response to RSPO2 in C2C12 cells, showing a requirement of LGR4 in RSPO signaling during myogenic differentiation.
Gpr48 deficiency induces polycystic kidney lesions and renal fibrosis in mice by activating Wnt signal pathway.
New
Ye et al., Shanghai, China. In Plos One, Dec 2013
G protein-coupled receptor 48 (Gpr48/Lgr4) is essential to regulate the development of multiple tissues in mice.
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.
New
Impact
Ning et al., Shanghai, China. In Nat Cell Biol, Dec 2013
Here, we show that Lgr4 homozygous mutant (Lgr4(m/m)) mice show reduced adiposity and resist dietary and leptin mutant-induced obesity with improved glucose metabolism.
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.
New
Impact
Stefansson et al., Reykjavík, Iceland. In Nature, Jun 2013
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.
Analysis of LGR4 receptor distribution in human and mouse tissues.
Liu et al., Houston, United States. In Plos One, 2012
LGR4 is an R-spondin receptor with strong positive effect on Wnt signaling.
Stat3 upregulates leucine-rich repeat-containing g protein-coupled receptor 4 expression in osteosarcoma cells.
Yan et al., Shanghai, China. In Biomed Res Int, 2012
In the present study, according to PCR-based microarrays using cDNA prepared from interleukin-6 (IL-6) treated osteosarcoma cells, we found that leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) was a transcriptional target of Stat3.
Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.
Gros et al., Utrecht, Netherlands. In Plos One, 2012
Conversely, binding of ZNRF3/RNF43 to LGR4-6 - R-spondin blocks Frizzled ubiquitination and enhances Wnt signaling.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Impact
Cong et al., Cambridge, United States. In Nature, 2012
Mechanistically, R-spondin interacts with the extracellular domain of ZNRF3 and induces the association between ZNRF3 and LGR4, which results in membrane clearance of ZNRF3.
GPR48 increases mineralocorticoid receptor gene expression.
GeneRIF
Ning et al., Shanghai, China. In J Am Soc Nephrol, 2012
GPR48 enhances aldosterone responsiveness by activating mineralocorticoid receptor expression.
LGR4 is required for the cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
GeneRIF
Nishimori et al., Sendai, Japan. In Biosci Biotechnol Biochem, 2011
LGR4 is required for cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Impact
Clevers et al., Utrecht, Netherlands. In Nature, 2011
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments.
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
GeneRIF
Liu et al., Houston, United States. In Proc Natl Acad Sci U S A, 2011
LGR4 and LGR5 bind the R-spondins with high affinity and mediate the potentiation of Wnt/beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation.
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo.
GeneRIF
Garcia et al., Brussels, Belgium. In Embo Rep, 2011
Our results identify LGR4 as a permissive factor in the Wnt pathway in the intestine
Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.
GeneRIF
Nishimori et al., Sendai, Japan. In Dev Dyn, 2011
Lgr4 has a novel function for maintaining the ureteric bud in an undifferentiated state.
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