RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
Houston, United States. In Proc Natl Acad Sci U S A, 17 Apr 2014
UNLABELLED: R-spondins (RSPOs) and their receptor leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) play pleiotropic roles in normal and cancer development as well as the survival of adult stem cells through potentiation of Wnt signaling.
R-spondins/Lgrs expression in tooth development.
London, United Kingdom. In Dev Dyn, 10 Apr 2014
The members of the R-spondin family are known as activators of Wnt signaling, and Lgr4, Lgr5 and Lgr6 have been identified as receptors for R-spondins.