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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 07 Dec 2014.

Leucine-rich repeat-containing G protein-coupled receptor 4

LGR4, GPR48, G protein-coupled receptor 48
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008] (from NCBI)
Top mentioned proteins: Lgr5, CAN, GPCR, HAD, Frizzled
Papers on LGR4
Complex Structure of LGR4 and Rspo1: Insights into the Divergent Mechanisms of Ligand Recognition by LGR Receptors.
Zhu et al., China. In J Biol Chem, 05 Jan 2015
Among the three groups of LGRs, group B members (LGR4-6) recognize R-spondin family proteins (Rspo1-4) to stimulate Wnt signaling.
Lgr4 is required for endometrial receptivity acquired through ovarian hormone signaling.
Nishimori et al., Sendai, Japan. In Biosci Biotechnol Biochem, 30 Nov 2014
Previously, using the Keratin5-Cre transgenic mouse model we reported that female Lgr4-conditional KO mice (Lgr4(K5 KO)) showed subfertility with defective stromal decidualization due to abnormal development of the uterine gland.
Lgr4 protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar parallel fiber-Purkinje cell synapses.
Liu et al., Shanghai, China. In J Biol Chem, Oct 2014
Here, we report that leucine-rich G protein-coupled receptor 4 (Lgr4/Gpr48) is highly expressed in Purkinje cells (PCs) in the cerebellum.
Lgr4 gene regulates corpus luteum maturation through modulation of the WNT-mediated EGFR-ERK signaling pathway.
Li et al., Shanghai, China. In Endocrinology, Sep 2014
Here we found that disruption of Lgr4/Gpr48, the newly identified receptor for R-spondins, greatly reduced female fertility in mice.
Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.
Tchorz et al., Basel, Switzerland. In Dev Biol, Jul 2014
Lgr4 and Lgr5 are known markers of adult and embryonic tissue stem cells in various organs.
Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut.
Vidal et al., Bethesda, United States. In Curr Biol, Jul 2014
Bursicon binding to its receptor, DLGR2, the ortholog of mammalian leucine-rich repeat-containing G protein-coupled receptors (LGR4-6), represses the production of the VM-derived EGF-like growth factor Vein through activation of cAMP.
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.
Clevers et al., Utrecht, Netherlands. In Genes Dev, Mar 2014
Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors.
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.
Ning et al., Shanghai, China. In Nat Cell Biol, Dec 2013
Here, we show that Lgr4 homozygous mutant (Lgr4(m/m)) mice show reduced adiposity and resist dietary and leptin mutant-induced obesity with improved glucose metabolism.
Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells.
Goidts et al., Nagoya, Japan. In Cancer Manag Res, Dec 2013
Recent studies have indicated that leucine-rich repeat-containing G-protein-coupled receptor 4 and 5 (LGR4 and LGR5) expression in multiple organs may represent a global marker of adult stem cells.
A naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals.
Luo et al., Taipei, Taiwan. In Plos One, Dec 2013
Leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) promotes the Wnt signaling through interaction with R-spondins or norrin.
[Ways to personalized medicine for gastric cancer].
Röcken, Kiel, Germany. In Pathologe, Sep 2013
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.
Stefansson et al., Reykjavík, Iceland. In Nature, Jun 2013
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.
Wakayama Symposium: Epithelial-mesenchymal interactions in eyelid development.
Ohuchi, Okayama, Japan. In Ocul Surf, 2012
These include FGFR2b-FGF10, EGFR-ERK, MEKK-JNK, BMP, Shh, Wnt, GPR48, Jun, Forkhead, and Grainyhead.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Cong et al., Cambridge, United States. In Nature, 2012
Mechanistically, R-spondin interacts with the extracellular domain of ZNRF3 and induces the association between ZNRF3 and LGR4, which results in membrane clearance of ZNRF3.
GPR48 increases mineralocorticoid receptor gene expression.
Ning et al., Shanghai, China. In J Am Soc Nephrol, 2012
GPR48 enhances aldosterone responsiveness by activating mineralocorticoid receptor expression.
LGR4 is required for the cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
Nishimori et al., Sendai, Japan. In Biosci Biotechnol Biochem, 2011
LGR4 is required for cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Clevers et al., Utrecht, Netherlands. In Nature, 2011
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments.
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Liu et al., Houston, United States. In Proc Natl Acad Sci U S A, 2011
LGR4 and LGR5 bind the R-spondins with high affinity and mediate the potentiation of Wnt/beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation.
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo.
Garcia et al., Brussels, Belgium. In Embo Rep, 2011
Our results identify LGR4 as a permissive factor in the Wnt pathway in the intestine
Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.
Nishimori et al., Sendai, Japan. In Dev Dyn, 2011
Lgr4 has a novel function for maintaining the ureteric bud in an undifferentiated state.
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