GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 27 Nov 2013.
Leucine-rich repeat-containing G protein-coupled receptor 4
LGR4, GPR48, G protein-coupled receptor 48
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008] (from
Nishimori et al., Sendai, Japan. In Faseb J, Sep 2013
UNLABELLED: In previous work we generated mice with a tissue specific ablation of a leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4) using the Keratin-5 (K5) Cre transgenic mouse strain (Lgr4(K5 KO)).
Stefansson et al., Reykjavík, Iceland. In Nature, Jun 2013
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.