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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Jul 2015.

Leucine-rich repeat-containing G protein-coupled receptor 4

LGR4, GPR48, G protein-coupled receptor 48
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008] (from NCBI)
Top mentioned proteins: Lgr5, GPCR, CAN, V1a, HAD
Papers on LGR4
Crystal Structure of R-Spondin 2 in Complex with the Ectodomains of its Receptors LGR5 and ZNRF3.
New
Yvonne Jones et al., Oxford, United Kingdom. In J Struct Biol, 26 Jul 2015
Rspo proteins act by cross-linking members of two cell surface receptor families, complexing the stem cell markers LGR4-6 with the Frizzled-specific E3 ubiquitin ligases ZNRF3/RNF43.
Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/Sirt1/Pgc1α pathway.
New
Ning et al., Shanghai, China. In Biochem Biophys Res Commun, 20 Jul 2015
UNASSIGNED: Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is a newfound obese-associated gene.
Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.
New
Caron et al., Durham, United States. In J Cell Sci, Apr 2015
We provide here a mechanism whereby the stem-cell marker Lgr5, and its family member Lgr4, promote the formation of cytonemes.
GPCR48/LGR4 promotes tumorigenesis of prostate cancer via PI3K/Akt signaling pathway.
New
Zhang et al., Zhengzhou, China. In Med Oncol, Mar 2015
However, the function of GPCR48/LGR4 in prostate cancer has not been fully investigated.
Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness.
New
Liu et al., Houston, United States. In Oncogene, Jan 2015
UNASSIGNED: The four R-spondins (RSPO1-4) and their three related receptors LGR4, 5 and 6 (LGR4-6) have emerged as a major ligand-receptor system with critical roles in development and stem cell survival through modulation of Wnt signaling.
Engineering high-potency R-spondin adult stem cell growth factors.
New
Pioszak et al., Oklahoma City, United States. In Mol Pharmacol, Dec 2014
Simultaneous binding of distinct regions of the RSPO Fu1-Fu2 domain module to the extracellular domains (ECDs) of the LGR4 G protein-coupled receptor and the ZNRF3 transmembrane E3 ubiquitin ligase regulates Wnt receptor availability.
Targeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation.
New
Qu et al., Wenzhou, China. In Plos One, Dec 2014
The leucine rich repeat containing G protein-coupled receptor 4 (LGR4, also known as GPR48), is important in many developmental processes.
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.
Review
New
Clevers et al., Utrecht, Netherlands. In Genes Dev, Mar 2014
Lgr5 and its homologs, Lgr4 and Lgr6, constitute the receptors for R-spondins, potent Wnt signal enhancers and stem cell growth factors.
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.
Impact
Ning et al., Shanghai, China. In Nat Cell Biol, 2013
Here, we show that Lgr4 homozygous mutant (Lgr4(m/m)) mice show reduced adiposity and resist dietary and leptin mutant-induced obesity with improved glucose metabolism.
Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells.
Review
Goidts et al., Nagoya, Japan. In Cancer Manag Res, 2013
Recent studies have indicated that leucine-rich repeat-containing G-protein-coupled receptor 4 and 5 (LGR4 and LGR5) expression in multiple organs may represent a global marker of adult stem cells.
[Ways to personalized medicine for gastric cancer].
Review
Röcken, Kiel, Germany. In Pathologe, 2013
AT1R, AT2R, CXCR4, FZD7, LGR4, LGR5, LGR6).
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.
Impact
Stefansson et al., Reykjavík, Iceland. In Nature, 2013
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.
Wakayama Symposium: Epithelial-mesenchymal interactions in eyelid development.
Review
Ohuchi, Okayama, Japan. In Ocul Surf, 2012
These include FGFR2b-FGF10, EGFR-ERK, MEKK-JNK, BMP, Shh, Wnt, GPR48, Jun, Forkhead, and Grainyhead.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Impact
Cong et al., Cambridge, United States. In Nature, 2012
Mechanistically, R-spondin interacts with the extracellular domain of ZNRF3 and induces the association between ZNRF3 and LGR4, which results in membrane clearance of ZNRF3.
GPR48 increases mineralocorticoid receptor gene expression.
GeneRIF
Ning et al., Shanghai, China. In J Am Soc Nephrol, 2012
GPR48 enhances aldosterone responsiveness by activating mineralocorticoid receptor expression.
LGR4 is required for the cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
GeneRIF
Nishimori et al., Sendai, Japan. In Biosci Biotechnol Biochem, 2011
LGR4 is required for cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Impact
Clevers et al., Utrecht, Netherlands. In Nature, 2011
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments.
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
GeneRIF
Liu et al., Houston, United States. In Proc Natl Acad Sci U S A, 2011
LGR4 and LGR5 bind the R-spondins with high affinity and mediate the potentiation of Wnt/beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation.
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo.
GeneRIF
Garcia et al., Brussels, Belgium. In Embo Rep, 2011
Our results identify LGR4 as a permissive factor in the Wnt pathway in the intestine
Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.
GeneRIF
Nishimori et al., Sendai, Japan. In Dev Dyn, 2011
Lgr4 has a novel function for maintaining the ureteric bud in an undifferentiated state.
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