LGR4 and Its Role in Intestinal Protection and Energy Metabolism.
Ann Arbor, United States. In Front Endocrinol (lausanne), Dec 2014
Distinct from classical G protein-coupled receptors which act via G proteins, LGR4 functions mainly through Wnt/β-catenin signaling to regulate cell proliferation, differentiation, and adult stem cell homeostasis.
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Uppsala, Sweden. In Genome Med, Dec 2014
Out of 107 CpG sites, 38 are located in gene promoters, including genes strongly implicated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1, SH2B1, ATXN2L, and IL27).
Wakayama Symposium: Epithelial-mesenchymal interactions in eyelid development.
Okayama, Japan. In Ocul Surf, 2012
These include FGFR2b-FGF10, EGFR-ERK, MEKK-JNK, BMP, Shh, Wnt, GPR48, Jun, Forkhead, and Grainyhead.