GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Leucine-rich repeat-containing G protein-coupled receptor 4
LGR4, GPR48, G protein-coupled receptor 48
G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008] (from
NCBI)
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Papers on
LGR4
Multi-functional norrin is a ligand for the LGR4 receptor.
New
In J Cell Sci, 26 Mar 2013
Mammalian LGR4, 5, and 6 are seven transmembrane receptors important for diverse physiological processes.
Oocyte-derived R-spondin2 promotes ovarian follicle development.
New
Stanford, United States. In Faseb J, 13 Mar 2013
R-spondin proteins are adult stem cell growth factors capable of stimulating gut development by activating LGR4, 5, and 6 receptors to promote Wnt signaling.
Lgr4 deficiency increases susceptibility and severity of dextran sodium sulphate-induced inflammatory bowel disease in mice.
New
China. In J Biol Chem, 07 Mar 2013
Lgr4 is one of the newly identified R-Spondins receptors and potentiates Wnt signaling which regulates intestinal homeostasis.
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.
New
Utrecht, Netherlands. In Gastroenterology, Dec 2012
Wnt signaling had a synergistic effect with the Lgr4/5 ligand R-spondin to induce formation of Paneth cells.
Wakayama symposium: epithelial-mesenchymal interactions in eyelid development.
New
Okayama, Japan. In Ocul Surf, Oct 2012
These include FGFR2b-FGF10, EGFR-ERK, MEKK-JNK, BMP, Shh, Wnt, GPR48, Jun, Forkhead, and Grainyhead.
LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma.
New
Kiel, Germany. In Virchows Arch, Oct 2012
We investigated the differential expression and putative tumor biological significance of five G-protein-coupled receptors (GPCRs) in GC, i.e., LGR4, LGR6, GPR34, GPR160, and GPR171.
A finger on the pulse of Wnt receptor signaling.
New
Boston, United States. In Cell Res, Oct 2012
R-spondin binds to ZNRF3, in addition to transmembrane LGR4/5 receptors, to antagonize degradation of the Wnt receptors by ZNRF3, thereby resulting in increased Frizzled and LRP6 levels and a greater Wnt response.
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
New
Impact
Cambridge, United States. In Nature, Jun 2012
Mechanistically, R-spondin interacts with the extracellular domain of ZNRF3 and induces the association between ZNRF3 and LGR4, which results in membrane clearance of ZNRF3.
GPR48 increases mineralocorticoid receptor gene expression.
New
Shanghai, China. In J Am Soc Nephrol, Feb 2012
We observed that G protein-coupled receptor 48 (Gpr48/Lgr4) hypomorphic mutant (Gpr48(m/m)) mice had hyperkalemia and increased water loss and salt excretion despite elevated plasma aldosterone levels, suggesting aldosterone resistance.
LGR4 is required for the cell survival of the peripheral mesenchyme at the embryonic stages of nephrogenesis.
Sendai, Japan. In Biosci Biotechnol Biochem, 2011
In mice, homozygous Lgr4 inactivation results in hypoplastic kidneys.
LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
Houston, United States. In Plos One, 2011
BACKGROUND: LGR6 (leucine-rich repeat containing, G protein-coupled receptor 6) is a member of the rhodopsin-like seven transmembrane domain receptor superfamily with the highest homology to LGR4 and LGR5.
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.
Basel, Switzerland. In Plos One, 2011
From this screen, we identified LGR4, then an orphan G protein-coupled receptor (GPCR), as the cognate receptor of RSPO.
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.
Heidelberg, Germany. In Embo Rep, 2011
Here we show that R-spondins bind to the orphan G-protein-coupled receptors LGR4 and LGR5 by their Furin domains.
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Impact
Utrecht, Netherlands. In Nature, 2011
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments.
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
GeneRIF
Houston, United States. In Proc Natl Acad Sci U S A, 2011
LGR4 and LGR5 bind the R-spondins with high affinity and mediate the potentiation of Wnt/beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation.
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo.
GeneRIF
Brussels, Belgium. In Embo Rep, 2011
Our results identify LGR4 as a permissive factor in the Wnt pathway in the intestine
Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.
GeneRIF
Sendai, Japan. In Dev Dyn, 2011
Lgr4 has a novel function for maintaining the ureteric bud in an undifferentiated state.
Reduced fertility with impairment of early-stage embryos observed in mice lacking Lgr4 in epithelial tissues.
GeneRIF
Sendai, Japan. In Fertil Steril, 2010
Relationship between the functions of Lgr4 and female reproductive systems.
Conditional knockout of Lgr4 leads to impaired ductal elongation and branching morphogenesis in mouse mammary glands.
Sendai, Japan. In Sex Dev, 2010
We have analyzed the function of LGR4 in the development of various mouse epithelial tissues.
GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation.
GeneRIF
Wenzhou, China. In Febs Lett, 2010
GPR48 is one of the constituents responsible for the EGFR signaling pathway with its effects directly linked to its ligand, HB-EGF.
