Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.
Nayoro, Japan. In Microbiol Immunol, Oct 2015
Viral double-stranded RNAs are reportedly sensed by the helicases DDX1, DDX21, DHX36, DHX9, DDX3, DDX41, LGP2 and DDX60, in addition to RIG-I and MDA5, and induce type I IFNs, thereby blocking viral replication.
Structural insights into RNA recognition by RIG-I.
New Haven, United States. In Cell, 2011
Intracellular RIG-I-like receptors (RLRs, including RIG-I, MDA-5, and LGP2) recognize viral RNAs as pathogen-associated molecular patterns (PAMPs) and initiate an antiviral immune response.
Immune signaling by RIG-I-like receptors.
Seattle, United States. In Immunity, 2011
The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity.