gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

DEXH

LGP2, LPG2, RNA helicase LGP2
Top mentioned proteins: RIG-I, MDA5, ACID, CAN, VISA
Papers on LGP2
Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells.
New
McDowell et al., Lexington, United States. In Plos Negl Trop Dis, Dec 2015
METHODOLOGY/PRINCIPAL FINDINGS: Here we explored the role of parasite glycoconjugates on the hDC IL12 response by generating L. major Friedlin V1 mutants defective in LPG alone, (FV1 lpg1-), or generally deficient for all PGs, (FV1 lpg2-).
Evolutionary conservation of molecular structure and antiviral function of a viral receptor, LGP2, in amphioxus Branchiostoma japonicum.
New
Zhang et al., Qingdao, China. In Eur J Immunol, Dec 2015
RIG-I-like (where RIG-I is retinoic acid inducible gene I) receptor LGP2 (where LGP2 is laboratory of genetics and physiology) is an important intracellular receptor that recognizes viral RNAs in innate immunity, but its origin and evolution remains unknown.
Characterization and expression analysis of laboratory of genetics and physiology 2 gene in sea perch, Lateolabrax japonicus.
New
Yi et al., Guangzhou, China. In Fish Shellfish Immunol, Nov 2015
LGP2 (laboratory of genetics and physiology 2) as a key component of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), plays a predominant role in modulating RLRs-mediated cellular antiviral signaling during viral infection.
Transcriptome comparative analysis revealed poly(I:C) activated RIG-I/MDA5-mediated signaling pathway in miiuy croaker.
New
Xu et al., Zhoushan, China. In Fish Shellfish Immunol, Nov 2015
In this pathway, both MDA5 and LGP2 are important RLRs in host surveillance against infection of dsRNA viruses and induce type I IFNs response which subsequently form a transcription factor complex ISGF3 that promote downstream genes referred to as ISGs to inhibits virus replication.
Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors.
Review
New
Hur et al., Boston, United States. In Trends Biochem Sci, Oct 2015
We will also discuss the closely related, but less understood, helicases, laboratory of genetics and physiology 2 (LGP2) and Dicer-related helicase-1 and -3 (DRH-1 and -3).
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.
New
Seya et al., Nayoro, Japan. In Microbiol Immunol, Oct 2015
Viral double-stranded RNAs are reportedly sensed by the helicases DDX1, DDX21, DHX36, DHX9, DDX3, DDX41, LGP2 and DDX60, in addition to RIG-I and MDA5, and induce type I IFNs, thereby blocking viral replication.
LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling.
Review
New
Horvath et al., Evanston, United States. In Cytokine, Aug 2015
The RLR family is composed of three homologous proteins, RIG-I, MDA5, and LGP2.
Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity.
Review
New
Gale et al., Seattle, United States. In Virol Sin, Jun 2015
The RLRs include RIG-I, MDA5, and LGP2.
Antiviral RNA recognition and assembly by RLR family innate immune sensors.
Review
Horvath et al., Evanston, United States. In Cytokine Growth Factor Rev, 2014
The RLR proteins, RIG-I, MDA5, and LGP2, share the ability to recognize nucleic acid signatures produced by virus infections and activate antiviral signaling.
Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5.
Review
Modis et al., New Haven, United States. In Front Immunol, 2013
This signaling process is under tight regulation, dependent on post-translational modifications of RIG-I and MDA5, and on regulatory proteins including unanchored ubiquitin chains and a third RLR, LGP2.
The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness.
Impact
GeneRIF
Gale et al., Seattle, United States. In Immunity, 2012
LGP2 promotes an essential prosurvival signal in response to antigen stimulation to confer CD8+ T cell-number expansion and effector functions against divergent RNA viruses, including West Nile virus and lymphocytic choriomeningitis virus.
Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction.
GeneRIF
Goodbourn et al., London, United Kingdom. In J Virol, 2012
Paramyxovirus 5 V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon beta induction.
Retinoic acid-inducible gene 1-like receptors in the upper respiratory tract.
GeneRIF
Cardell et al., Malmö, Sweden. In Am J Rhinol Allergy, 2011
the present study shows the presence of RIG-1,MDA-5, and LGP-2 in the human upper airways, most prominently inthe epithelium.
Structural insights into RNA recognition by RIG-I.
Impact
Pyle et al., New Haven, United States. In Cell, 2011
Intracellular RIG-I-like receptors (RLRs, including RIG-I, MDA-5, and LGP2) recognize viral RNAs as pathogen-associated molecular patterns (PAMPs) and initiate an antiviral immune response.
Ambivalent role of the innate immune response in rabies virus pathogenesis.
GeneRIF
Lafon et al., Paris, France. In J Virol, 2011
LGP2 functions as an inhibitor of the innate immune response triggered by Rabeis virus infection
Immune signaling by RIG-I-like receptors.
Review
Impact
Gale et al., Seattle, United States. In Immunity, 2011
The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity.
Impaired cellular responses to cytosolic DNA or infection with Listeria monocytogenes and vaccinia virus in the absence of the murine LGP2 protein.
GeneRIF
Horvath et al., Evanston, United States. In Plos One, 2010
findings demonstrate a regulatory role for LGP2 in the response to cytosolic DNA, an intracellular bacterial pathogen, and a DNA virus, and provide a plausible mechanistic hypothesis as the basis for this activity
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Impact
Hornung et al., Bonn, Germany. In Nat Immunol, 2009
RNA is sensed by Toll-like receptor 7 (TLR7) and TLR8 or by the RNA helicases LGP2, Mda5 and RIG-I to trigger antiviral responses.
Persistence without pathology in phosphoglycan-deficient Leishmania major.
Impact
Beverley et al., Saint Louis, United States. In Science, 2003
Leishmania major lacking phosphoglycans (lpg2-) were unable to survive in sand flies and macrophages, but retained the ability to persist indefinitely in the mammalian host without inducing disease.
share on facebooktweetadd +1mail to friends