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Importin 13

Lgl2, importin 13, IPO13, LLGL2, imp13
This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: importin, V1a, CAN, MBL, E-cadherin
Papers on Lgl2
The impact of genetic factors on response to glucocorticoids therapy in IBD.
Dobrowolska et al., Poznań, Poland. In Scand J Gastroenterol, Feb 2016
To those genes belong: NR3C1 - responsible for the synthesis of GC receptor (GR); Hsp90, HSP70, STIP1, FKB5 - genes of GR protein complex; ABCB1 and IPO13 coding glycoprotein p170; and importin 13 - involved in GCs transport; IL1A, IL1B, IL2, IL4, IL8, IL10, TNF, and MIF - genes of the epithelial pro-inflammatory factors synthesis, which excessive activation causes steroid resistance as well as CYP3A4 and CYP3A5 - encoding GCs biotransformation enzymes.
Dissemination of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa in Romania.
Naas et al., Cluj-Napoca / Kolozsvár, Romania. In Antimicrob Agents Chemother, Nov 2015
One KPC-, nine NDM-1-, four OXA-48-, and one VIM-4-producing Enterobacteriaceae isolates along with 11 VIM-2-producing and one IMP-13-producing P. aeruginosa isolates were recovered from clinical samples.
SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.
Muñoz et al., Madrid, Spain. In Oncogene, Nov 2015
Moreover, SPRY2 represses LLGL2/HUGL2, PATJ1/INADL and ST14, main regulators of the polarized epithelial phenotype, and ESRP1, an epithelial-to-mesenchymal transition (EMT) inhibitor.
High-Resolution Analysis by Whole-Genome Sequencing of an International Lineage (Sequence Type 111) of Pseudomonas aeruginosa Associated with Metallo-Carbapenemases in the United Kingdom.
Woodford et al., London, United Kingdom. In J Clin Microbiol, Aug 2015
Most isolates (73) carried VIM-2, but others carried IMP-1 or IMP-13 (5) or NDM-1 (1); one isolate had VIM-2 and IMP-18, and 7 carried no metallo-beta-lactamase (MBL) gene.
Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study.
Fujimaki et al., Tsu, Japan. In Int J Mol Med, May 2015
Longitudinal analysis with a generalized estimating equation and with adjustment for age, gender, body mass index and smoking status revealed that rs2116519 of family with sequence similarity 78, member B (FAM78B; P=0.0266), rs6929846 of butyrophilin, subfamily 2, member A1 (BTN2A1; P=0.0013), rs146021107 of pancreatic and duodenal homeobox 1 (PDX1; P=0.0031) and rs1671021 of lethal giant larvae homolog 2 (Drosophila) (LLGL2; P=0.0372) were significantly (P<0.05)
Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis.
Ekker et al., Rochester, United States. In Plos One, 2014
Moreover, knockdown of the epithelial polarity regulator and tumor suppressor lgl2 ameliorated the nrg2a mutant phenotype.
Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.
Yoon et al., Seoul, South Korea. In Nat Commun, 2014
Casein kinase 2 alpha phosphorylates PDCD5 at Ser-119 to enhance its stability and importin 13-mediated nuclear translocation of PDCD5.
Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.
Strelkov et al., Leuven, Belgium. In Acta Crystallogr Sect F Struct Biol Commun, 2014
The first nine repeats form a `cradle' for the binding of RanGTP, revealing similarities but also differences with respect to the related importin 13 complex.
Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype.
Pommier et al., Bethesda, United States. In Plos One, 2013
The most highly correlated genes were implicated in the following epithelial functions: interactions at tight junctions (CLDN7, CLDN4, CLDN3, MARVELD3, MARVELD2, TJP3, CGN, CRB3, LLGL2, EPCAM, LNX1); interactions at adherens junctions (CDH1, ADAP1, CAMSAP3); interactions at desmosomes (PPL, PKP3, JUP); transcription regulation of cell-cell junction complexes (GRHL1 and 2); epithelial RNA splicing regulators (ESRP1 and 2); epithelial vesicle traffic (RAB25, EPN3, GRHL2, EHF, ADAP1, MYO5B); epithelial Ca(+2) signaling (ATP2C2, S100A14, BSPRY); terminal differentiation of epithelial cells (OVOL1 and 2, ST14, PRSS8, SPINT1 and 2); maintenance of apico-basal polarity (RAB25, LLGL2, EPN3).
A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif.
Parker et al., London, United Kingdom. In Sci Signal, 2013
We identified a protein interaction surface containing a dibasic motif (RIPR) that bound a distinct subset of PKCι substrates including lethal giant larvae 2 (LLGL2) and myosin X, but not other substrates such as Par3.
CCCTC-binding factor controls its own nuclear transport via regulating the expression of importin 13.
Zhu et al., Beijing, China. In Mol Cells, 2013
In this study, we showed that the expression of CTCF influenced the intracellular distribution of itself, which might go through transport receptor - import 13 (IPO13).
Expression and subcellular distribution of imp13 are regulated in brain development.
Tao et al., Xiamen, China. In In Vitro Cell Dev Biol Anim, 2013
Imp13, a member of importin-β superfamily, is found to be one of two bidirectional transport receptors in many nuclear transport activities in mammals.
Lethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle.
Amack et al., Syracuse, United States. In Development, 2013
In the zebrafish embryo, lethal giant larvae 2 (lgl2) is expressed prominently in ciliated organs.
Difficult-to-detect carbapenem-resistant IMP13-producing P. aeruginosa: experience feedback concerning a cluster of urinary tract infections at a surgical clinic in France.
Van der Mee-Marquet et al., Tours, France. In Antimicrob Resist Infect Control, 2012
Despite an MIC of imipenem in the susceptibility range for two isolates, all were metallo-β-lactamase-producers (IMP13-type, clone ST621).
Increased importin 13 activity is associated with the pathogenesis of pterygium.
Liu et al., Xiamen, China. In Mol Vis, 2012
PURPOSE: We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation.
Increased expression of importin13 in endometriosis and endometrial carcinoma.
Kang et al., Chongqing, China. In Med Sci Monit, 2012
These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma.
The expression levels of stem cell markers importin13, c-kit, CD146, and telomerase are decreased in endometrial polyps.
Yuan et al., Chongqing, China. In Med Sci Monit, 2011
Data show that expression of IPO13, c-kit, telomerase, caspase3, and CD146 are decreased in endometrial polyps; however, the expression of bcl-2 was increased in polyps compared to the normal endometrial tissue.
Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta.
Lauwers et al., Worcester, United States. In Virchows Arch, 2010
There is a role of Lgl2 immunohistochemistry as an adjunct in the diagnosis of foveolar-type gastric dysplasia.
The nuclear import of the constitutive androstane receptor by importin/Ran-GTP systems.
Inouye et al., Funabashi, Japan. In Biochim Biophys Acta, 2010
Data show that nuclear import of CAR is regulated by importin/Ran-GTP systems.
Immunohistochemistry for cell polarity protein lethal giant larvae 2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias.
Mino-Kenudson et al., Boston, United States. In Hum Pathol, 2010
Lgl2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias.
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