Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Jackson, United States. In Oncogene, Sep 2015
Here we report differential regulation of Notch receptors by Lunatic Fringe (Lfng), which encodes an O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase known to modify epidermal growth factor repeats in the Notch extracellular domain, during pathogenesis of Kras-induced pancreatic ductal adenocarcinoma (PDAC).
On the origin of vertebrate somites.
Kōbe, Japan. In Zoological Lett, 2014
In vertebrates, the somite segmental boundary is determined by Notch signalling and the antagonistic relationship of the downstream targets of Notch, Lfng, and Delta1 in the anterior PSM.