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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Aug 2015.


This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, adiponectin, fibrillin-1, HAD, AGE
Papers using leptin antibodies
Leptin is the modulator of HSP60 gene expression in AR42J cells
Frühbeck Gema et al., In Mediators of Inflammation, 2005
... The control and pair-fed groups received vehicle (PBS), while leptin-treated mice were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice daily ...
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.
Calbet Jose A. L., In PLoS ONE, 2004
... were placed under caloric restriction (2 g standard chow diet/day) and were daily injected with recombinant leptin (2 g/kg body weight) (Bachem, Bubendorf, Switzerland) in order ...
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Acharya Subrat K. et al., In The Indian Journal of Medical Research, 2003
... : Commercial ELISA assays kits were used to measure serum level of TNFα, IL-1, IL-6, leptin (Cayman Chemical Company, Michigan, USA, ...
PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Ballock R. Tracy et al., In PPAR Research, 2003
... Tri-iodothyronine (T3, Sigma), leptin (Sigma), and ciglitazone (BioMol, Plymouth Meeting, PA) were ...
Dissecting autocrine effects on pulsatile release of gonadotropin-releasing hormone in cultured rat hypothalamic tissue
Shin Choong Ho et al., In Korean Journal of Pediatrics, 2003
... Recombinant mouse leptin (>98% pure) was purchased from Biodesign International, Meridian Life Science, ...
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Papers on leptin
Leptin applications in 2015: what have we learned about leptin and obesity?
Mantzoros et al., Boston, United States. In Curr Opin Endocrinol Diabetes Obes, 31 Oct 2015
PURPOSE OF REVIEW: To summarize previous and current advancements for leptin therapeutics, we described how leptin may be useful in leptin deficient states such as lipodystrophy, for which leptin was recently approved, and how it may be useful in the future for typical obesity.
Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation.
Scherer et al., Dallas, United States. In Nat Cell Biol, 30 Sep 2015
C/EBPα is essential for all white adipogenic conditions in the adult stage, such as adipose tissue regeneration, adipogenesis in muscle and unhealthy expansion of white adipose tissue during high-fat feeding or due to leptin deficiency.
Dietary Whey and Casein Differentially Affect Energy Balance, Gut Hormones, Glucose Metabolism, and Taste Preference in Diet-Induced Obese Rats.
Chelikani et al., Calgary, Canada. In J Nutr, 26 Sep 2015
Circulating leptin, glucose-dependent insulinotropic polypeptide, interleukin 6, and glucose concentrations were lower in WH, CA, and WHCA rats than in CO rats.
Multigenerational Undernutrition Increases Susceptibility to Obesity and Diabetes that Is Not Reversed after Dietary Recuperation.
Yajnik et al., Sydney, Australia. In Cell Metab, 04 Sep 2015
Undernourished rats also have higher circulating insulin, homocysteine, endotoxin and leptin levels, lower adiponectin, vitamin B12 and folate levels, and an 8-fold increased susceptibility to Streptozotocin-induced diabetes compared to control rats.
60 YEARS OF NEUROENDOCRINOLOGY: TRH, the first hypophysiotropic releasing hormone isolated: control of the pituitary-thyroid axis.
Charli et al., Ecatepec, Mexico. In J Endocrinol, 31 Aug 2015
The activity of TRH neurons is regulated by nutritional status through neurons of the arcuate nucleus, which sense metabolic signals such as circulating leptin levels.
Developmental influences on circuits programming susceptibility to obesity.
Zeltser, New York City, United States. In Front Neuroendocrinol, 20 Aug 2015
Neonatal leptin administration exerts lasting impacts on susceptibility to obesity in rodents.
Circadian Dysfunction Induces Leptin Resistance in Mice.
Fu et al., Houston, United States. In Cell Metab, 07 Aug 2015
Our comprehensive screen of wild-type and three circadian mutant mouse models, with or without chronic jet lag, shows that distinct genetic and physiologic interventions differentially disrupt overall energy homeostasis and Leptin signaling.
Amylin: Pharmacology, Physiology, and Clinical Potential.
Roth et al., Zürich, Switzerland. In Pharmacol Rev, 31 Jul 2015
Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol.
Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes.
Mobasheri et al., Santiago de Compostela, Spain. In Life Sci, 18 Jul 2015
Recent data suggests that metabolic factors produced by white adipose tissue, such as leptin, may provide a mechanistic link between obesity and OA, providing an explanation for the high prevalence of OA among obese and over-weight individuals.
The role of adipokines in gestational diabetes mellitus.
Azar et al., New York City, United States. In Ther Adv Endocrinol Metab, Jun 2015
Our review suggests that, in GDM, various adipokines, mainly leptin and adiponectin, are dysregulated.
[Gestational diabetes in the light of current literature].
Łopucki et al., Chełm, Poland. In Pol Merkur Lekarski, Jun 2015
In the development of gestational diabetes mellitus important role apart from maternal and fetal hyperinsulinemia play: antagonistic to insulin placental hormones, TNFα, placental pro-inflammatory cytokines, resistin, leptin ghrelin.
Does grandparents' diet affect weight and risk of hypogonadism in subsequent generations?
Sharpe et al., Edinburgh, United Kingdom. In Lancet, Mar 2015
F2 male offspring (n=4-7) derived from HFD maternal grandfathers were 7·7% heavier (p=0·029), exhibited a 31% increase in visceral adiposity (p=0·032), a 97% increase in plasma leptin (p=0·027), a trend for lower testosterone (p=0·057), and an increase in the luteinising hormone to testosterone ratio (p=0·017).
FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes.
Sun et al., China. In Sci Rep, Dec 2014
UNASSIGNED: Fatty acid binding protein 4 (FABP4), plays key role in fatty acid transportation and oxidation, and increases with leptin synergistically during adipose inflammation process.
In Search of Biomarkers for Idiopathic Scoliosis: Leptin and BMP4 Functional Polymorphisms.
Kremensky et al., Sofia, Bulgaria. In J Biomark, Dec 2014
In the present study the association of two functional polymorphisms of leptin (rs7799039) and BMP4 (rs4898820) with susceptibility to IS and curve severity was investigated in a Bulgarian population sample.
Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates.
Yen et al., Kao-hsiung, Taiwan. In Neuropsychiatr Dis Treat, Dec 2014
But the association between depression (or anxiety symptoms) and serum leptin is still unclear and controversial, despite the growing body of evidence supporting the existence of "leptin resistance" in obese persons.
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
Bence et al., Philadelphia, United States. In Am J Physiol Endocrinol Metab, 2012
Data suggest that leptin and PTP1B (protein tyrosine phosphatase 1B) are important components in energy balance regulation by pro-opiomelanocortin neurons in hindbrain. PTP1B knockout mice are hypersensitive to administration of leptin to hindbrain.
Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.
Kraft et al., Durham, United States. In Am J Respir Crit Care Med, 2012
Leptin levels were increased in overweight/obese subjects and were significantly higher in overweight/obese subjects with asthma. Alveolar macrophages from overweight/obese subjects with asthma are uniquely sensitive to leptin.
[Association between leptin gene promoter methylation and type 2 diabetes mellitus].
Li et al., Wuhan, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
The methylation rates of leptin gene in IGR and T2DM groups were 43.6 % and 31.5 %, respectively, which were significantly lower than that of healthy subjects (59.2%; Chi-square=22.499 and 5.109, respectively, P<0.05).
Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers.
Bouslama et al., Sousse, Tunisia. In Genet Test Mol Biomarkers, 2012
LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity.
Hennige et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
a crosstalk of leptin and insulin in the brain which leads to a decline in locomotor activity
More papers using leptin antibodies
Divergent effects of soy protein diet on the expression of adipocytokines
Naito Michitaka et al., In Journal of Clinical Biochemistry and Nutrition, 2002
An insulin kit was purchased from Sibayagi (Gunma, Japan), a leptin kit was purchased from Biovendor Laboratory Medicine (Brno, Czech ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Ghribi Othman et al., In Molecular Neurodegeneration, 2000
... Leptin, Aβ42, and rapamycin were purchased from Sigma Aldrich (St ...
Cerebrospinal cytokine levels in patients with acute depression
Dąbrowski Piotr et al., In Mediators of Inflammation, 1998
... Leptin was measured using a commercially available highly sensitive ELISA kits (BioVendor Laboratory Medicine Inc., Czech ...
Expression of cell adhesion molecules in murine placentas and a placental cell line.
Bobé Pierre, In PLoS ONE, 1998
... Plasma leptin levels were measured by ELISA (Cayman Chemical Company, Ann Arbor, ...
The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system.
Calbet Jose A. L., In PLoS ONE, 1987
... The control and pair-fed groups received vehicle (PBS), while leptin-treated groups were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice a day ...
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