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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.


This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, adiponectin, fibrillin-1, HAD, AGE
Papers using leptin antibodies
Leptin is the modulator of HSP60 gene expression in AR42J cells
Frühbeck Gema et al., In Mediators of Inflammation, 2005
... The control and pair-fed groups received vehicle (PBS), while leptin-treated mice were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice daily ...
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.
Calbet Jose A. L., In PLoS ONE, 2004
... were placed under caloric restriction (2 g standard chow diet/day) and were daily injected with recombinant leptin (2 g/kg body weight) (Bachem, Bubendorf, Switzerland) in order ...
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Acharya Subrat K. et al., In The Indian Journal of Medical Research, 2003
... : Commercial ELISA assays kits were used to measure serum level of TNFα, IL-1, IL-6, leptin (Cayman Chemical Company, Michigan, USA, ...
PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Ballock R. Tracy et al., In PPAR Research, 2003
... Tri-iodothyronine (T3, Sigma), leptin (Sigma), and ciglitazone (BioMol, Plymouth Meeting, PA) were ...
Dissecting autocrine effects on pulsatile release of gonadotropin-releasing hormone in cultured rat hypothalamic tissue
Shin Choong Ho et al., In Korean Journal of Pediatrics, 2003
... Recombinant mouse leptin (>98% pure) was purchased from Biodesign International, Meridian Life Science, ...
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Papers on leptin
Claessens et al., Leuven, Belgium. In Endocrinology, 12 Dec 2015
Both models displayed higher adiposity and serum leptin levels upon HFD, while no differences were seen on a regular diet.
Biochemical markers of placental dysfunction in assisted conception.
Cooke et al., Belfast, United Kingdom. In Hum Fertil (camb), 11 Dec 2015
This was investigated by measuring plasma concentrations of biochemical markers: (i) soluble fms-like tyrosine kinase1 (sFlt1); (ii) placental growth factor (PlGF); (iii) leptin; and (iv) plasminogen activator inhibitor 2 (PAI-2), serially at four antenatal time points.
Short-term effects of a hypocaloric diet with low glycemic index and low glycemic load on body adiposity, metabolic variables, ghrelin, leptin, and pregnancy rate in overweight and obese infertile women: a randomized controlled trial.
Moulin et al., Porto Alegre, Brazil. In Am J Clin Nutr, 11 Dec 2015
OBJECTIVE: We investigated the effects of a hypocaloric diet with an LGI and low glycemic load on anthropometric and metabolic variables, ghrelin and leptin concentrations, and the pregnancy rate in overweight and obese infertile women who were undergoing in vitro fertilization (IVF).
Factors related to increased resting energy expenditure in men with liver cirrhosis.
Quiroga et al., Madrid, Spain. In Eur J Gastroenterol Hepatol, 09 Dec 2015
leptin (P<0.05), and leptin adjusted per fat mass (FM) (P<0.05),
Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology.
Iadecola et al., Laizhou, China. In Biochim Biophys Acta, 03 Dec 2015
Here we offer a brief appraisal of how changes in body weight and adiposity are related to both AD and dementia on vascular basis, and examine the involvement of two key adipocyte-derived hormones: leptin and adiponectin.
Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages.
Shi et al., Boston, United States. In Cell Metab, 14 Nov 2015
Rampant body weight gain in ob/ob mice, a strain that lacks leptin, associates with reduced MC content in WAT.
Running on Empty: Leptin Signaling in VTA Regulates Reward from Physical Activity.
Kenny et al., New York City, United States. In Cell Metab, 06 Nov 2015
(2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.
Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal.
Morrison et al., Dallas, United States. In Nature, 01 Nov 2015
Nearly all HSCs contacted leptin receptor positive (Lepr(+)) and Cxcl12(high) niche cells, and approximately 85% of HSCs were within 10 μm of a sinusoidal blood vessel.
Physiology and pathophysiology of IGFBP-1 and IGFBP-2 - Consensus and dissent on metabolic control and malignant potential.
Russo et al., Germany. In Best Pract Res Clin Endocrinol Metab, 31 Oct 2015
IGFBP-2 is further regulated by leptin and has been demonstrated to affect insulin sensitivity and glucose tolerance, further supporting a particular role of IGFBP-2 in glucose and fat metabolism.
The soluble leptin receptor.
Kratzsch et al., Leipzig, Germany. In Best Pract Res Clin Endocrinol Metab, 31 Oct 2015
The adipokine leptin realizes signal transduction via four different leptin receptor (OB-R) isoforms.
Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms.
Grill et al., Philadelphia, United States. In Biol Psychiatry, 28 Oct 2015
Also discussed are recent findings demonstrating that peripherally derived endocrine signals act on receptors in hippocampal neurons to reduce (leptin, glucagon-like peptide-1) or increase (ghrelin) food intake and learned food reward-driven responding, thereby highlighting endocrine and neuropeptidergic signaling in hippocampal neurons as a novel substrate of importance in the higher-order regulation of feeding behavior.
A Sympathetic View on Fat by Leptin.
Horvath et al., New Haven, United States. In Cell, 24 Oct 2015
reveal that the lipolytic effect of the hormone leptin is mediated by sympathetic nerve fibers that directly "envelope" white adipocytes.
Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis.
Domingos et al., New York City, United States. In Cell, 24 Oct 2015
Leptin is a hormone produced by the adipose tissue that acts in the brain, stimulating white fat breakdown.
Potential Biomarkers of Fat Loss as a Feature of Cancer Cachexia.
Mazurak et al., Edmonton, Canada. In Mediators Inflamm, Dec 2014
Plasma glycerol and leptin associate with adipose tissue atrophy and mass, respectively; however, no study has evaluated their potential as a prognostic biomarker of cachexia-associated fat loss.
Search for an Endogenous Bombesin-Like Receptor 3 (BRS-3) Ligand Using Parabiotic Mice.
Reitman et al., Bethesda, United States. In Plos One, Dec 2014
Brs3 null (Brs3-/y) mice become obese.
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
Bence et al., Philadelphia, United States. In Am J Physiol Endocrinol Metab, 2012
Data suggest that leptin and PTP1B (protein tyrosine phosphatase 1B) are important components in energy balance regulation by pro-opiomelanocortin neurons in hindbrain. PTP1B knockout mice are hypersensitive to administration of leptin to hindbrain.
Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.
Kraft et al., Durham, United States. In Am J Respir Crit Care Med, 2012
Leptin levels were increased in overweight/obese subjects and were significantly higher in overweight/obese subjects with asthma. Alveolar macrophages from overweight/obese subjects with asthma are uniquely sensitive to leptin.
[Association between leptin gene promoter methylation and type 2 diabetes mellitus].
Li et al., Wuhan, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
The methylation rates of leptin gene in IGR and T2DM groups were 43.6 % and 31.5 %, respectively, which were significantly lower than that of healthy subjects (59.2%; Chi-square=22.499 and 5.109, respectively, P<0.05).
Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers.
Bouslama et al., Sousse, Tunisia. In Genet Test Mol Biomarkers, 2012
LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity.
Hennige et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
a crosstalk of leptin and insulin in the brain which leads to a decline in locomotor activity
More papers using leptin antibodies
Divergent effects of soy protein diet on the expression of adipocytokines
Naito Michitaka et al., In Journal of Clinical Biochemistry and Nutrition, 2002
An insulin kit was purchased from Sibayagi (Gunma, Japan), a leptin kit was purchased from Biovendor Laboratory Medicine (Brno, Czech ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Ghribi Othman et al., In Molecular Neurodegeneration, 2000
... Leptin, Aβ42, and rapamycin were purchased from Sigma Aldrich (St ...
Cerebrospinal cytokine levels in patients with acute depression
Dąbrowski Piotr et al., In Mediators of Inflammation, 1998
... Leptin was measured using a commercially available highly sensitive ELISA kits (BioVendor Laboratory Medicine Inc., Czech ...
Expression of cell adhesion molecules in murine placentas and a placental cell line.
Bobé Pierre, In PLoS ONE, 1998
... Plasma leptin levels were measured by ELISA (Cayman Chemical Company, Ann Arbor, ...
The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system.
Calbet Jose A. L., In PLoS ONE, 1987
... The control and pair-fed groups received vehicle (PBS), while leptin-treated groups were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice a day ...
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