Amylin: Pharmacology, Physiology, and Clinical Potential.
Zürich, Switzerland. In Pharmacol Rev, 31 Jul 2015
Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol.
[Gestational diabetes in the light of current literature].
Chełm, Poland. In Pol Merkur Lekarski, 22 Jul 2015
In the development of gestational diabetes mellitus important role apart from maternal and fetal hyperinsulinemia play: antagonistic to insulin placental hormones, TNFα, placental pro-inflammatory cytokines, resistin, leptin ghrelin.
Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes.
Santiago de Compostela, Spain. In Life Sci, 18 Jul 2015
Recent data suggests that metabolic factors produced by white adipose tissue, such as leptin, may provide a mechanistic link between obesity and OA, providing an explanation for the high prevalence of OA among obese and over-weight individuals.
Drug targeting of leptin resistance.
Napoli, Italy. In Life Sci, 09 Jul 2015
Indeed, this adipocyte-derived hormone, whose circulating levels mirror fat mass, not only exerts its anti-obesity effects mainly modulating the activity of specific hypothalamic neurons expressing the long form of the leptin receptor (Ob-Rb), but it also shows pleiotropic functions due to the activation of Ob-Rb in peripheral tissues.
Fucoxanthin and lipid metabolism: A minireview.
Kiev, Ukraine. In Nutr Metab Cardiovasc Dis, 03 Jul 2015
It should however be noted that in diabetic/obese KK-Ay mice with genetically compromised insulin signaling, fucoxanthin might increase the plasma levels of cholesterol and low-density lipoproteins.
Leptin keeps working, even in obesity.
Ann Arbor, United States. In Cell Metab, 02 Jul 2015
The concept of leptin resistance posits that elevated endogenous leptin fails to decrease food intake in obese animals due to diminished leptin signaling.
Treatment of obesity with celastrol.
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Boston, United States. In Cell, 21 Jun 2015
Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but it is ineffective in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mouse models.