Association of the leptin receptor Gln223 Arg polymorphism with lipid profile in obese Pakistani subjects.
Lahore, Pakistan. In Nutrition, 30 Sep 2015
CONCLUSIONS: The LEPR Gln223 is associated with obesity, lipid parameters, and plasma glucose in all subjects, with weight, body mass index, and systolic and diastolic blood pressure only in obese subjects, but showed no association with leptin, insulin, and HOMA-IR in a Pakistani study group.
Circadian Dysfunction Induces Leptin Resistance in Mice.
Houston, United States. In Cell Metab, 07 Aug 2015
Our comprehensive screen of wild-type and three circadian mutant mouse models, with or without chronic jet lag, shows that distinct genetic and physiologic interventions differentially disrupt overall energy homeostasis and Leptin signaling.
Amylin: Pharmacology, Physiology, and Clinical Potential.
Zürich, Switzerland. In Pharmacol Rev, 31 Jul 2015
Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol.
Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes.
Santiago de Compostela, Spain. In Life Sci, 18 Jul 2015
Recent data suggests that metabolic factors produced by white adipose tissue, such as leptin, may provide a mechanistic link between obesity and OA, providing an explanation for the high prevalence of OA among obese and over-weight individuals.
Leptin keeps working, even in obesity.
Ann Arbor, United States. In Cell Metab, 02 Jul 2015
The concept of leptin resistance posits that elevated endogenous leptin fails to decrease food intake in obese animals due to diminished leptin signaling.
[Gestational diabetes in the light of current literature].
Chełm, Poland. In Pol Merkur Lekarski, Jun 2015
In the development of gestational diabetes mellitus important role apart from maternal and fetal hyperinsulinemia play: antagonistic to insulin placental hormones, TNFα, placental pro-inflammatory cytokines, resistin, leptin ghrelin.
Treatment of obesity with celastrol.
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Boston, United States. In Cell, Jun 2015
Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but it is ineffective in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mouse models.