Decelerating mature adipocyte dedifferentiation by media composition.
Stuttgart, Germany. In Tissue Eng Part C Methods, 31 Aug 2015
In our study we showed that DMEM/Ham´s F-12 with 10 % FCS reported for the culture of mature adipocytes favors dedifferentiation, which was accompanied by a high glycerol release, a decreasing release of leptin and a low expression of the adipocyte marker perilipin A, but high expression of CD73 after 21 days.
Circadian Dysfunction Induces Leptin Resistance in Mice.
Houston, United States. In Cell Metab, 07 Aug 2015
Our comprehensive screen of wild-type and three circadian mutant mouse models, with or without chronic jet lag, shows that distinct genetic and physiologic interventions differentially disrupt overall energy homeostasis and Leptin signaling.
Amylin: Pharmacology, Physiology, and Clinical Potential.
Zürich, Switzerland. In Pharmacol Rev, 31 Jul 2015
Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol.
Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes.
Santiago de Compostela, Spain. In Life Sci, 18 Jul 2015
Recent data suggests that metabolic factors produced by white adipose tissue, such as leptin, may provide a mechanistic link between obesity and OA, providing an explanation for the high prevalence of OA among obese and over-weight individuals.
Leptin keeps working, even in obesity.
Ann Arbor, United States. In Cell Metab, 02 Jul 2015
The concept of leptin resistance posits that elevated endogenous leptin fails to decrease food intake in obese animals due to diminished leptin signaling.
[Gestational diabetes in the light of current literature].
Chełm, Poland. In Pol Merkur Lekarski, Jun 2015
In the development of gestational diabetes mellitus important role apart from maternal and fetal hyperinsulinemia play: antagonistic to insulin placental hormones, TNFα, placental pro-inflammatory cytokines, resistin, leptin ghrelin.
Treatment of obesity with celastrol.
Boston, United States. In Cell, Jun 2015
Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but it is ineffective in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mouse models.
The Role of Kisspeptin in the Onset of Puberty and in the Ovulatory Mechanism: A Mini-review.
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Santiago, Chile. In J Pediatr Adolesc Gynecol, Nov 2014
The points under discussion are (1) the characteristics of kisspeptin and its receptor, (2) the relevance of this hormone and its interaction with leptin in the onset of puberty, (3) the role of kisspeptin in the ovulatory mechanism based on its differential expression at hypothalamic nuclei, which is modulated by sex steroid hormones, and (4) the clinical relevance of kisspeptin and its antagonists in new therapeutic strategies for the treatment of various reproductive pathologies.