Metabolic reprogramming of the heart through stearoyl-CoA desaturase.
Warsaw, Poland. In Prog Lipid Res, 04 Jan 2015
Furthermore, SCD4, a heart-specific isoform of SCD, is specifically repressed by leptin and the lack of SCD1 function in leptin-deficient ob/ob mice results in a decrease in the accumulation of neutral lipids and ceramide and improves the systolic and diastolic function of a failing heart.
Dietary intakes and leptin concentrations.
Eşfahān, Iran. In Arya Atheroscler, Sep 2014
BACKGROUND: Leptin, a peptide contained 146 amino-acids, is mostly secreted from adipose tissue and it has a critical role on regulation of body weight, body fat mass, appetite, and food intakes.
Leptin signaling molecular actions and drug target in hepatocellular carcinoma.
More papers using
Jinan, China. In Drug Des Devel Ther, Dec 2013
The stringent binding affinity of leptin and its receptor Ob-R, as well as the highly upregulated expression of both leptin and Ob-R in cancer cells compared to normal cells, makes leptin an ideal drug target for the prevention and treatment of HCC, especially in obese patients.