gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 05 Mar 2015.

Leptin

leptin
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, adiponectin, fibrillin-1, AGE, HAD
Papers using leptin antibodies
Leptin is the modulator of HSP60 gene expression in AR42J cells
Supplier
Frühbeck Gema et al., In Mediators of Inflammation, 2005
... The control and pair-fed groups received vehicle (PBS), while leptin-treated mice were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice daily ...
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.
Supplier
Calbet Jose A. L., In PLoS ONE, 2004
... were placed under caloric restriction (2 g standard chow diet/day) and were daily injected with recombinant leptin (2 g/kg body weight) (Bachem, Bubendorf, Switzerland) in order ...
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Supplier
Acharya Subrat K. et al., In The Indian Journal of Medical Research, 2003
... : Commercial ELISA assays kits were used to measure serum level of TNFα, IL-1, IL-6, leptin (Cayman Chemical Company, Michigan, USA, ...
PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Supplier
Ballock R. Tracy et al., In PPAR Research, 2003
... Tri-iodothyronine (T3, Sigma), leptin (Sigma), and ciglitazone (BioMol, Plymouth Meeting, PA) were ...
Dissecting autocrine effects on pulsatile release of gonadotropin-releasing hormone in cultured rat hypothalamic tissue
Supplier
Shin Choong Ho et al., In Korean Journal of Pediatrics, 2003
... Recombinant mouse leptin (>98% pure) was purchased from Biodesign International, Meridian Life Science, ...
more suppliers
Papers on leptin
Metabolic profiling in Prader-Willi syndrome and non-syndromic obesity: sex differences and the role of growth hormone.
New
Freemark et al., Durham, United States. In Clin Endocrinol (oxf), 04 Apr 2015
METHODS: We compared amino acids, fatty acids, and acylcarnitines in GH-treated and untreated PWS children and obese and lean controls to identify biomarkers associated with ghrelin, peptide YY, and markers of insulin sensitivity (adiponectin and HOMA-IR).
Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling.
New
Takeda et al., Tokyo, Japan. In Mol Metab, 31 Mar 2015
The discovery that the anorexigenic hormone leptin regulates bone mass via neuronal pathways revealed that neurons and neuropeptides are intimately involved in bone homeostasis.
SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes.
New
Donato et al., São Paulo, Brazil. In Mol Metab, 31 Mar 2015
Based on these results, we generated a conditional knockout mouse that lacks the suppressor of cytokine signaling-3 (SOCS3) only in leptin receptor-expressing cells and studied these animals during pregnancy.
Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes.
New
Altarejos et al., Orlando, United States. In Mol Metab, 31 Mar 2015
OBJECTIVE: Leptin alleviates hyperglycemia in rodent models of Type 1 diabetes by activating leptin receptors within the central nervous system.
Associations of serum adiponectin and leptin with Barrett's esophagus.
New
Chak et al., Philadelphia, United States. In Clin Gastroenterol Hepatol, 28 Mar 2015
Serum levels of adiponectin and leptin are deregulated in obese states and implicated as putative mediators in the pathophysiology of esophageal columnar metaplasia.
A short review of adipokines, smooth muscle and uterine contractility.
Review
New
Wray et al., Liverpool, United Kingdom. In Life Sci, 21 Mar 2015
In the UK, for example, 60% of adults are overweight and 25% are obese.
Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system.
Review
New
Nair et al., Riverside, United States. In Cytokine, 18 Mar 2015
Though they are responsive to adipokines, particularly lipoproteins, leptin, and adiponectin, macrophages generally do not synthesize their own adipokines, with the exception being resistin-like molecules.
Recurrent miscarriage: causes, evaluation and management.
Review
New
Alijotas-Reig et al., Barcelona, Spain. In Postgrad Med J, 13 Mar 2015
New immunological approaches such as natural killer cells, regulatory T cells, tumour necrosis factor α, cell-derived microparticles, leptin, certain glycoproteins and cytokines should be considered.
Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals.
Review
New
Kalsbeek et al., Amsterdam, Netherlands. In Mol Cell Endocrinol, 05 Mar 2015
The sleep-wake cycle, the feeding/fasting rhythm and most hormonal rhythms, including that of leptin, ghrelin and glucocorticoids, usually show an opposite phase (relative to the light-dark cycle) in diurnal and nocturnal species.
Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat.
New
Impact
Tiganis et al., Australia. In Cell, 15 Feb 2015
Here, we report that insulin and leptin act together on hypothalamic neurons to promote WAT browning and weight loss.
A new biology of diabetes revealed by leptin.
New
Impact
Roth et al., Dallas, United States. In Cell Metab, 06 Feb 2015
A variety of leptin actions require a re-examination of classic concepts of metabolic diseases.
Biologically inactive leptin and early-onset extreme obesity.
New
Impact
Fischer-Posovszky et al., Gauting, Germany. In N Engl J Med, Feb 2015
Mutations in the gene encoding leptin (LEP) typically lead to an absence of circulating leptin and to extreme obesity.
Leptin mediates the increase in blood pressure associated with obesity.
New
Impact
Cowley et al., Australia. In Cell, Jan 2015
We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or leptin receptors (LepR).
Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy.
Review
New
James et al., Sydney, Australia. In Front Endocrinol (lausanne), Dec 2014
The largest depot, subcutaneous white fat [subcutaneous white adipose tissue (SAT)], has important beneficial characteristics including storage of lipid "out of harms way" and secretion of adipokines, especially leptin and adiponectin, with positive metabolic effects including lipid oxidation, energy utilization, enhanced insulin action, and an anti-inflammatory role.
An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease.
New
Impact
Walsh et al., Boston, United States. In Nat Med, Dec 2014
In mice, VEGF-A165b expression was upregulated by conditions associated with impaired limb revascularization, including leptin deficiency, diet-induced obesity, genetic ablation of the secreted frizzled-related protein 5 (Sfrp5) adipokine and transgenic overexpression of Wnt5a in myeloid cells.
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
GeneRIF
Bence et al., Philadelphia, United States. In Am J Physiol Endocrinol Metab, 2012
Data suggest that leptin and PTP1B (protein tyrosine phosphatase 1B) are important components in energy balance regulation by pro-opiomelanocortin neurons in hindbrain. PTP1B knockout mice are hypersensitive to administration of leptin to hindbrain.
Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.
GeneRIF
Kraft et al., Durham, United States. In Am J Respir Crit Care Med, 2012
Leptin levels were increased in overweight/obese subjects and were significantly higher in overweight/obese subjects with asthma. Alveolar macrophages from overweight/obese subjects with asthma are uniquely sensitive to leptin.
[Association between leptin gene promoter methylation and type 2 diabetes mellitus].
GeneRIF
Li et al., Wuhan, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
The methylation rates of leptin gene in IGR and T2DM groups were 43.6 % and 31.5 %, respectively, which were significantly lower than that of healthy subjects (59.2%; Chi-square=22.499 and 5.109, respectively, P<0.05).
Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers.
GeneRIF
Bouslama et al., Sousse, Tunisia. In Genet Test Mol Biomarkers, 2012
LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity.
GeneRIF
Hennige et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
a crosstalk of leptin and insulin in the brain which leads to a decline in locomotor activity
More papers using leptin antibodies
Divergent effects of soy protein diet on the expression of adipocytokines
Supplier
Naito Michitaka et al., In Journal of Clinical Biochemistry and Nutrition, 2002
An insulin kit was purchased from Sibayagi (Gunma, Japan), a leptin kit was purchased from Biovendor Laboratory Medicine (Brno, Czech ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Supplier
Ghribi Othman et al., In Molecular Neurodegeneration, 2000
... Leptin, Aβ42, and rapamycin were purchased from Sigma Aldrich (St ...
Cerebrospinal cytokine levels in patients with acute depression
Supplier
Dąbrowski Piotr et al., In Mediators of Inflammation, 1998
... Leptin was measured using a commercially available highly sensitive ELISA kits (BioVendor Laboratory Medicine Inc., Czech ...
Expression of cell adhesion molecules in murine placentas and a placental cell line.
Supplier
Bobé Pierre, In PLoS ONE, 1998
... Plasma leptin levels were measured by ELISA (Cayman Chemical Company, Ann Arbor, ...
The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system.
Supplier
Calbet Jose A. L., In PLoS ONE, 1987
... The control and pair-fed groups received vehicle (PBS), while leptin-treated groups were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice a day ...
share on facebooktweetadd +1mail to friends