Treatment of obesity with celastrol.
Boston, United States. In Cell, 21 Jun 2015
Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but it is ineffective in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mouse models.
Leptin resistance in obesity: An epigenetic landscape.
Santiago de Compostela, Spain. In Life Sci, 18 Jun 2015
However, most obese individuals and subjects with a predisposition to regain weight after losing it have leptin concentrations than lean individuals, but despite the anorexigenic function of this hormone, appetite is not effectively suppressed in these individuals.
Effects of exercise on brain functions in diabetic animal models.
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Asan, South Korea. In World J Diabetes, 15 Jun 2015
Additionally, many physiopathologic alterations are caused in the brain by DM such as increased adiposity, inflammation, hormonal dysregulation, uncontrolled hyperphagia, insulin and leptin resistance, and dysregulation of neurotransmitters and declined neurogenesis in the hippocampus and we describe how exercise corrects these alterations in animal models.