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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Oct 2015.


This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, adiponectin, fibrillin-1, AGE, HAD
Papers using leptin antibodies
Leptin is the modulator of HSP60 gene expression in AR42J cells
Frühbeck Gema et al., In Mediators of Inflammation, 2005
... The control and pair-fed groups received vehicle (PBS), while leptin-treated mice were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice daily ...
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.
Calbet Jose A. L., In PLoS ONE, 2004
... were placed under caloric restriction (2 g standard chow diet/day) and were daily injected with recombinant leptin (2 g/kg body weight) (Bachem, Bubendorf, Switzerland) in order ...
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Acharya Subrat K. et al., In The Indian Journal of Medical Research, 2003
... : Commercial ELISA assays kits were used to measure serum level of TNFα, IL-1, IL-6, leptin (Cayman Chemical Company, Michigan, USA, ...
PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Ballock R. Tracy et al., In PPAR Research, 2003
... Tri-iodothyronine (T3, Sigma), leptin (Sigma), and ciglitazone (BioMol, Plymouth Meeting, PA) were ...
Dissecting autocrine effects on pulsatile release of gonadotropin-releasing hormone in cultured rat hypothalamic tissue
Shin Choong Ho et al., In Korean Journal of Pediatrics, 2003
... Recombinant mouse leptin (>98% pure) was purchased from Biodesign International, Meridian Life Science, ...
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Papers on leptin
Interplay of atherogenic factors, protein intake and betatrophin levels in obese-metabolic syndrome patients treated with hypocaloric diets.
Casanueva et al., Santiago de Compostela, Spain. In Int J Obes (lond), 07 Nov 2015
UNASSIGNED: CONTEXTThe understanding of the potential role of betatrophin in human metabolic disorders is a current challenge.OBJECTIVEThe present research evaluated circulating betatrophin levels in obese patients with metabolic syndrome features under energy-restricted weight-loss programs and in normal weight in order to stablish the putative interplay between the levels of this hormone, diet and metabolic risk factors linked to obesity and associated comorbidities.SUBJECTS AND METHODSOne-hundred and forty three participants were enrolled in the study (95 obese-metabolic syndrome; age 49.5±9.4
Reduction in Aβ-induced cell death in the hippocampus of 17β-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone.
Barrios et al., Alcalá de Henares, Spain. In J Neurochem, 07 Nov 2015
As alterations in somatostatin have been demonstrated in Alzheimer's disease, we examined whether E2 prevents changes in the hippocampal somatostatinergic system induced by Aβ25-35 and cell death, as well as the possible involvement of leptin and insulin-like growth factor (IGF)-I signaling.
Increased leptin levels correlate with thyroid autoantibodies in non-obese males.
Worley et al., Durham, United States. In Clin Endocrinol (oxf), 07 Nov 2015
We then stratified men and women into obese (BMI > 30) or non-obese (BMI ≤ 30) subgroups and determined the association between leptin levels and anti-TPO antibody titers for each subgroup.
Running on Empty: Leptin Signaling in VTA Regulates Reward from Physical Activity.
Kenny et al., New York City, United States. In Cell Metab, 06 Nov 2015
(2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.
Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal.
Morrison et al., Dallas, United States. In Nature, 01 Nov 2015
Nearly all HSCs contacted leptin receptor positive (Lepr(+)) and Cxcl12(high) niche cells, and approximately 85% of HSCs were within 10 μm of a sinusoidal blood vessel.
Are leptin levels increased among people with schizophrenia versus controls? A systematic review and comparative meta-analysis.
Miller et al., London, United Kingdom. In Psychoneuroendocrinology, 30 Oct 2015
OBJECTIVE: Leptin may play a role in the pathophysiology of schizophrenia and it remains unclear if levels are raised compared to controls.
Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis.
Domingos et al., New York City, United States. In Cell, 24 Oct 2015
Leptin is a hormone produced by the adipose tissue that acts in the brain, stimulating white fat breakdown.
A Sympathetic View on Fat by Leptin.
Horvath et al., New Haven, United States. In Cell, 24 Oct 2015
reveal that the lipolytic effect of the hormone leptin is mediated by sympathetic nerve fibers that directly "envelope" white adipocytes.
Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma.
Pchejetski et al., Amman, Jordan. In Oncotarget, 10 Oct 2015
Here, we review the role of adipose tissue from an endocrine perspective and outline the effect of adipokines on cancer metabolism, with particular focus on leptin.
Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons.
Fulton et al., Montréal, Canada. In Cell Metab, 01 Oct 2015
UNASSIGNED: The adipose hormone leptin potently influences physical activity.
Cardiovascular Disease in South Asian Migrants.
Anand et al., Toronto, Canada. In Can J Cardiol, 30 Sep 2015
Novel biomarkers like leptin and adipokines may show distinct patterns in SAs and provide insights into cardiometabolic risk determinants.
Developmental influences on circuits programming susceptibility to obesity.
Zeltser, New York City, United States. In Front Neuroendocrinol, Aug 2015
Neonatal leptin administration exerts lasting impacts on susceptibility to obesity in rodents.
Early Life Nutrition and Energy Balance Disorders in Offspring in Later Life.
Vickers et al., Auckland, New Zealand. In Nutrients, Dec 2014
However there is evidence from intervention studies which indicate altered wiring of the hypothalamic circuits that regulate energy balance and epigenetic effects including altered DNA methylation of key adipokines including leptin.
Plasticity of the Melanocortin System: Determinants and Possible Consequences on Food Intake.
Benani et al., Dijon, France. In Front Endocrinol (lausanne), Dec 2014
Interestingly, composition and abundance of pre-synaptic inputs onto arcuate AgRP and POMC neurons vary in the adult hypothalamus in response to changes in the metabolic state, a phenomenon that can be recapitulated by treatment with hormones, such as leptin or ghrelin.
Leptin Is Required for Glucose Homeostasis after Roux-en-Y Gastric Bypass in Mice.
Aguirre et al., Dallas, United States. In Plos One, Dec 2014
BACKGROUND & AIMS: Leptin, the protein product of the ob gene, increases energy expenditure and reduces food intake, thereby promoting weight reduction.
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
Bence et al., Philadelphia, United States. In Am J Physiol Endocrinol Metab, 2012
Data suggest that leptin and PTP1B (protein tyrosine phosphatase 1B) are important components in energy balance regulation by pro-opiomelanocortin neurons in hindbrain. PTP1B knockout mice are hypersensitive to administration of leptin to hindbrain.
Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.
Kraft et al., Durham, United States. In Am J Respir Crit Care Med, 2012
Leptin levels were increased in overweight/obese subjects and were significantly higher in overweight/obese subjects with asthma. Alveolar macrophages from overweight/obese subjects with asthma are uniquely sensitive to leptin.
[Association between leptin gene promoter methylation and type 2 diabetes mellitus].
Li et al., Wuhan, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
The methylation rates of leptin gene in IGR and T2DM groups were 43.6 % and 31.5 %, respectively, which were significantly lower than that of healthy subjects (59.2%; Chi-square=22.499 and 5.109, respectively, P<0.05).
Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers.
Bouslama et al., Sousse, Tunisia. In Genet Test Mol Biomarkers, 2012
LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity.
Hennige et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
a crosstalk of leptin and insulin in the brain which leads to a decline in locomotor activity
More papers using leptin antibodies
Divergent effects of soy protein diet on the expression of adipocytokines
Naito Michitaka et al., In Journal of Clinical Biochemistry and Nutrition, 2002
An insulin kit was purchased from Sibayagi (Gunma, Japan), a leptin kit was purchased from Biovendor Laboratory Medicine (Brno, Czech ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Ghribi Othman et al., In Molecular Neurodegeneration, 2000
... Leptin, Aβ42, and rapamycin were purchased from Sigma Aldrich (St ...
Cerebrospinal cytokine levels in patients with acute depression
Dąbrowski Piotr et al., In Mediators of Inflammation, 1998
... Leptin was measured using a commercially available highly sensitive ELISA kits (BioVendor Laboratory Medicine Inc., Czech ...
Expression of cell adhesion molecules in murine placentas and a placental cell line.
Bobé Pierre, In PLoS ONE, 1998
... Plasma leptin levels were measured by ELISA (Cayman Chemical Company, Ann Arbor, ...
The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system.
Calbet Jose A. L., In PLoS ONE, 1987
... The control and pair-fed groups received vehicle (PBS), while leptin-treated groups were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice a day ...
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