Extracellular matrix in obesity - cancer interactions.
In Horm Mol Biol Clin Investig, 14 May 2015
Furthermore, obesity affects almost all body systems including the extracellular matrix (ECM) by generating a pro-inflammatory environment, which are associated with abnormal secretions of several cytokines or hormonal substances, for example, insulin-like growth factors (IGFs), leptin, and sex hormones.
Phenomenon of leptin resistance in seasonal animals: the failure of leptin action in the brain.
Kraków, Poland. In Domest Anim Endocrinol, 14 Apr 2015
UNASSIGNED: The core of the leptin resistance hypothesis promulgated several years ago to explain obesity as a result of environmental causes consists of 2 tenets: the extinction of leptin-induced intracellular signaling downstream of leptin binding to the long form of the neuronal receptor LTRb in the hypothalamus and the impedance to leptin entry imposed at the blood-brain barrier (BBB).
The impact of sleep and circadian disturbance on hormones and metabolism.
Seoul, South Korea. In Int J Endocrinol, Dec 2014
The regulation and metabolism of several hormones are influenced by interactions between the effects of sleep and the intrinsic circadian system; growth hormone, melatonin, cortisol, leptin, and ghrelin levels are highly correlated with sleep and circadian rhythmicity.
Role of non-neuronal cells in body weight and appetite control.
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Madrid, Spain. In Front Endocrinol (lausanne), Dec 2014
Indeed, microglia and astrocytes participate in the hypothalamic inflammatory response to high fat diet (HFD)-induced obesity, with this process contributing to inflammatory-related insulin and leptin resistance.