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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Jul 2015.


This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, adiponectin, fibrillin-1, AGE, HAD
Papers using leptin antibodies
Leptin is the modulator of HSP60 gene expression in AR42J cells
Frühbeck Gema et al., In Mediators of Inflammation, 2005
... The control and pair-fed groups received vehicle (PBS), while leptin-treated mice were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice daily ...
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.
Calbet Jose A. L., In PLoS ONE, 2004
... were placed under caloric restriction (2 g standard chow diet/day) and were daily injected with recombinant leptin (2 g/kg body weight) (Bachem, Bubendorf, Switzerland) in order ...
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Acharya Subrat K. et al., In The Indian Journal of Medical Research, 2003
... : Commercial ELISA assays kits were used to measure serum level of TNFα, IL-1, IL-6, leptin (Cayman Chemical Company, Michigan, USA, ...
PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Ballock R. Tracy et al., In PPAR Research, 2003
... Tri-iodothyronine (T3, Sigma), leptin (Sigma), and ciglitazone (BioMol, Plymouth Meeting, PA) were ...
Dissecting autocrine effects on pulsatile release of gonadotropin-releasing hormone in cultured rat hypothalamic tissue
Shin Choong Ho et al., In Korean Journal of Pediatrics, 2003
... Recombinant mouse leptin (>98% pure) was purchased from Biodesign International, Meridian Life Science, ...
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Papers on leptin
Amylin: Pharmacology, Physiology, and Clinical Potential.
Roth et al., Zürich, Switzerland. In Pharmacol Rev, 31 Jul 2015
Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol.
MicroRNA-29a Mitigates Glucocorticoid Induction of Bone Loss and Fatty Marrow by Rescuing Runx2 Acetylation.
Wang et al., Kao-hsiung, Taiwan. In Bone, 30 Jul 2015
Through inhibition of histone deacetylase 4 (HDAC4) expression, miR-29a restored acetylated Runx2 and β-catenin abundances and reduced RANKL, leptin and glucocorticoid receptor expression in glucocorticoid-mediated osteoporosis bone tissues.
The novel SNPs of leptin gene and their associations with growth traits in Chinese Nanjiang Yellow goat.
Zhong et al., Chengdu, China. In Gene, 30 Jul 2015
UNASSIGNED: The leptin gene (LEP) encodes a protein that greatly affects the regulation of body weight, energy balance, and food intake in mammals.
Maternal high-fat diet acts as a stressor increasing maternal glucocorticoids' signaling to the fetus and disrupting maternal behavior and brain activation in C57BL/6J mice.
Cirulli et al., Roma, Italy. In Psychoneuroendocrinology, 24 Jul 2015
Basal corticosterone plasma levels and brain levels of c-Fos were measured both before and after delivery, in addition to leptin levels in the adipose tissue.
[Gestational diabetes in the light of current literature].
Łopucki et al., Chełm, Poland. In Pol Merkur Lekarski, 22 Jul 2015
In the development of gestational diabetes mellitus important role apart from maternal and fetal hyperinsulinemia play: antagonistic to insulin placental hormones, TNFα, placental pro-inflammatory cytokines, resistin, leptin ghrelin.
Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes.
Mobasheri et al., Santiago de Compostela, Spain. In Life Sci, 18 Jul 2015
Recent data suggests that metabolic factors produced by white adipose tissue, such as leptin, may provide a mechanistic link between obesity and OA, providing an explanation for the high prevalence of OA among obese and over-weight individuals.
Drug targeting of leptin resistance.
Meli et al., Napoli, Italy. In Life Sci, 09 Jul 2015
Indeed, this adipocyte-derived hormone, whose circulating levels mirror fat mass, not only exerts its anti-obesity effects mainly modulating the activity of specific hypothalamic neurons expressing the long form of the leptin receptor (Ob-Rb), but it also shows pleiotropic functions due to the activation of Ob-Rb in peripheral tissues.
Twenty-four-hour profiles of metabolic and stress hormones in sheep selected for a calm or nervous temperament.
Blache et al., Australia. In Domest Anim Endocrinol, 09 Jul 2015
In resting "calm" (n = 8) and "nervous" (n = 8) sheep, concentrations of cortisol, prolactin, leptin, and insulin were measured in blood plasma sampled via jugular catheter every 20 min for 24 h.
Fucoxanthin and lipid metabolism: A minireview.
Fraifeld et al., Kiev, Ukraine. In Nutr Metab Cardiovasc Dis, 03 Jul 2015
It should however be noted that in diabetic/obese KK-Ay mice with genetically compromised insulin signaling, fucoxanthin might increase the plasma levels of cholesterol and low-density lipoproteins.
Leptin keeps working, even in obesity.
Myers, Ann Arbor, United States. In Cell Metab, 02 Jul 2015
The concept of leptin resistance posits that elevated endogenous leptin fails to decrease food intake in obese animals due to diminished leptin signaling.
Diet-induced obese mice retain endogenous leptin action.
Perez-Tilve et al., Cincinnati, United States. In Cell Metab, 02 Jul 2015
To directly determine endogenous leptin activity in obesity, we treated lean and obese mice with a leptin receptor antagonist.
The role of adipokines in gestational diabetes mellitus.
Azar et al., New York City, United States. In Ther Adv Endocrinol Metab, 30 Jun 2015
Our review suggests that, in GDM, various adipokines, mainly leptin and adiponectin, are dysregulated.
Treatment of obesity with celastrol.
Ozcan et al., Boston, United States. In Cell, 21 Jun 2015
Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but it is ineffective in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mouse models.
Relationship of adiponectin and its multimers to metabolic indices in cats during weight change.
Lauten et al., Knoxville, United States. In Domest Anim Endocrinol, 14 Jun 2015
This study uses a novel method of size-exclusion gel chromatography combined with enzyme-linked immunosorbent assay to measure HMW feline adiponectin and determine its relationship to leptin, cholesterol, and insulin sensitivity as cats gain and lose weight.
Leptin and insulin act on POMC neurons to promote the browning of white fat.
Tiganis et al., Australia. In Cell, Feb 2015
Here, we report that insulin and leptin act together on hypothalamic neurons to promote WAT browning and weight loss.
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
Bence et al., Philadelphia, United States. In Am J Physiol Endocrinol Metab, 2012
Data suggest that leptin and PTP1B (protein tyrosine phosphatase 1B) are important components in energy balance regulation by pro-opiomelanocortin neurons in hindbrain. PTP1B knockout mice are hypersensitive to administration of leptin to hindbrain.
Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.
Kraft et al., Durham, United States. In Am J Respir Crit Care Med, 2012
Leptin levels were increased in overweight/obese subjects and were significantly higher in overweight/obese subjects with asthma. Alveolar macrophages from overweight/obese subjects with asthma are uniquely sensitive to leptin.
[Association between leptin gene promoter methylation and type 2 diabetes mellitus].
Li et al., Wuhan, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
The methylation rates of leptin gene in IGR and T2DM groups were 43.6 % and 31.5 %, respectively, which were significantly lower than that of healthy subjects (59.2%; Chi-square=22.499 and 5.109, respectively, P<0.05).
Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers.
Bouslama et al., Sousse, Tunisia. In Genet Test Mol Biomarkers, 2012
LEP G2548A and LEPR Q223R polymorphisms and haplotype combination were associated with MetS and obesity risk in Tunisian volunteers.
Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity.
Hennige et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
a crosstalk of leptin and insulin in the brain which leads to a decline in locomotor activity
More papers using leptin antibodies
Divergent effects of soy protein diet on the expression of adipocytokines
Naito Michitaka et al., In Journal of Clinical Biochemistry and Nutrition, 2002
An insulin kit was purchased from Sibayagi (Gunma, Japan), a leptin kit was purchased from Biovendor Laboratory Medicine (Brno, Czech ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Ghribi Othman et al., In Molecular Neurodegeneration, 2000
... Leptin, Aβ42, and rapamycin were purchased from Sigma Aldrich (St ...
Cerebrospinal cytokine levels in patients with acute depression
Dąbrowski Piotr et al., In Mediators of Inflammation, 1998
... Leptin was measured using a commercially available highly sensitive ELISA kits (BioVendor Laboratory Medicine Inc., Czech ...
Expression of cell adhesion molecules in murine placentas and a placental cell line.
Bobé Pierre, In PLoS ONE, 1998
... Plasma leptin levels were measured by ELISA (Cayman Chemical Company, Ann Arbor, ...
The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system.
Calbet Jose A. L., In PLoS ONE, 1987
... The control and pair-fed groups received vehicle (PBS), while leptin-treated groups were intraperitoneally administered with leptin (Bachem, Bubendorf, Switzerland) twice a day ...
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