Statin treatment and new-onset diabetes: a review of proposed mechanisms.
Montréal, Canada. In Metabolism, Jun 2014
Other possible mechanisms implicated in the effect of statins on new-onset diabetes are: statin interference with intracellular insulin signal transduction pathways via inhibition of necessary phosphorylation events and reduction of small GTPase action; inhibition of adipocyte differentiation leading to decreased peroxisome proliferator activated receptor gamma and CCAAT/enhancer-binding protein which are important pathways for glucose homeostasis; decreased leptin causing inhibition of β-cells proliferation and insulin secretion; and diminished adiponectin levels.
The effects of light at night on circadian clocks and metabolism.
Columbus, United States. In Endocr Rev, Apr 2014
Multiple genes involved in nutrient metabolism display rhythmic oscillations, and metabolically related hormones such as glucagon, insulin, ghrelin, leptin, and corticosterone are released in a circadian fashion.
Metabolism of activated T lymphocytes.
Saskatoon, Canada. In Curr Opin Immunol, Apr 2014
Upon activation, T cells express the insulin and leptin receptors on their surface and become sensitive to insulin signaling and nutrient availability and show changes in differentiation.
Regulation of hepatic energy metabolism and gluconeogenesis by BAD.
Boston, United States. In Cell Metab, Mar 2014
The physiologic relevance of these findings is evident from the ability of a BAD phosphomimic variant to counteract unrestrained gluconeogenesis and improve glycemia in leptin-resistant and high-fat diet models of diabetes and insulin resistance.
Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.
Saint-Pierre-des-Corps, France. In Cell Metab, Mar 2014
Triggering ERK signaling in tanycytes with EGF reestablishes leptin transport, elicits MBH neuron activation and energy expenditure in obese animals, and accelerates the restoration of leptin sensitivity upon the return to a normal-fat diet.
New concepts in white adipose tissue physiology.
Limeira, Brazil. In Braz J Med Biol Res, Feb 2014
In addition to leptin, other biologically active substances secreted by AT, generally classified as cytokines, include adiponectin, interleukin-6, tumor necrosis factor-alpha, resistin, vaspin, visfatin, and many others now collectively referred to as adipokines.
Obesity: Friend or foe for osteoporosis.
Jammu, India. In J Midlife Health, Jan 2014
Adipocytes secret leptin, adiponectin, adipsin, as well as proinflammatory cytokines, that contributes in pathogenesis of osteoporosis.
[New insights into adipose cell biology].
More papers using
In Bull Acad Natl Med, 2013
We then found that the enteric-vagal nervous system transmits this nutritional information towards the brain stem and hypothalamus, where leptin, neuropeptide Y and GLP-1 relay the enteric signal to control the endocrine pancreas (insulin-glucagon secretion), the liver (glycogen metabolism), the vascular system (vasodilation, arterial flow), and muscle metabolism.