Leptin applications in 2015: what have we learned about leptin and obesity?
Boston, United States. In Curr Opin Endocrinol Diabetes Obes, 31 Oct 2015
PURPOSE OF REVIEW: To summarize previous and current advancements for leptin therapeutics, we described how leptin may be useful in leptin deficient states such as lipodystrophy, for which leptin was recently approved, and how it may be useful in the future for typical obesity.
Dietary Whey and Casein Differentially Affect Energy Balance, Gut Hormones, Glucose Metabolism, and Taste Preference in Diet-Induced Obese Rats.
Calgary, Canada. In J Nutr, 26 Sep 2015
Circulating leptin, glucose-dependent insulinotropic polypeptide, interleukin 6, and glucose concentrations were lower in WH, CA, and WHCA rats than in CO rats.
Circadian Dysfunction Induces Leptin Resistance in Mice.
Houston, United States. In Cell Metab, 07 Aug 2015
Our comprehensive screen of wild-type and three circadian mutant mouse models, with or without chronic jet lag, shows that distinct genetic and physiologic interventions differentially disrupt overall energy homeostasis and Leptin signaling.
Amylin: Pharmacology, Physiology, and Clinical Potential.
Zürich, Switzerland. In Pharmacol Rev, 31 Jul 2015
Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol.
Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes.
Santiago de Compostela, Spain. In Life Sci, 18 Jul 2015
Recent data suggests that metabolic factors produced by white adipose tissue, such as leptin, may provide a mechanistic link between obesity and OA, providing an explanation for the high prevalence of OA among obese and over-weight individuals.
[Gestational diabetes in the light of current literature].
Chełm, Poland. In Pol Merkur Lekarski, Jun 2015
In the development of gestational diabetes mellitus important role apart from maternal and fetal hyperinsulinemia play: antagonistic to insulin placental hormones, TNFα, placental pro-inflammatory cytokines, resistin, leptin ghrelin.
Does grandparents' diet affect weight and risk of hypogonadism in subsequent generations?
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Edinburgh, United Kingdom. In Lancet, Mar 2015
F2 male offspring (n=4-7) derived from HFD maternal grandfathers were 7·7% heavier (p=0·029), exhibited a 31% increase in visceral adiposity (p=0·032), a 97% increase in plasma leptin (p=0·027), a trend for lower testosterone (p=0·057), and an increase in the luteinising hormone to testosterone ratio (p=0·017).