Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma.
Amman, Jordan. In Oncotarget, Dec 2015
Both high levels of leptin in circulation and leptin receptor mutation are associated with prostate cancer risk in human patients; however, the in vivo mechanistic evidence is less conclusive.Given the complexity of metabolic cancer pathways, it is possible that leptin may have varying effects on prostate cancer at different stages of its development, a point that may be addressed by further epidemiological studies.
The soluble leptin receptor.
Leipzig, Germany. In Best Pract Res Clin Endocrinol Metab, Oct 2015
The adipokine leptin realizes signal transduction via four different leptin receptor (OB-R) isoforms.
[Expression of neuropeptide Y and long leptin receptor in gastrointestinal tract of giant panda].
In Sheng Wu Gong Cheng Xue Bao, Aug 2015
To study the expression and distribution of neuropeptide Y (NPY) and long leptin receptor (OB-Rb) in the gastrointestinal tract of giant panda, samples of three animals were collected from the key laboratory for reproduction and conservation genetics of endangered wildlife of Sichuan province, China conservation and research center for the giant panda.
Treatment of obesity with celastrol.
Boston, United States. In Cell, Jun 2015
Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic diet-induced obese (DIO) mice by increasing leptin sensitivity, but it is ineffective in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mouse models.