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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Left right determination factor 1

Lefty1, Lefty, LEFTB
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on Lefty1
Transforming growth factor β and Ras/MEK/ERK signaling regulate the expression level of a novel tumor suppressor Lefty.
GeneRIF
Hibi et al., Tokyo, Japan. In Pancreas, 2012
Data suggest that Lefty is a novel TGF-beta target molecule that mediates growth inhibition of pancreatic cancer cells.
Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system.
Impact
GeneRIF
Schier et al., Cambridge, United States. In Science, 2012
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish.
GeneRIF
Burdine et al., Princeton, United States. In Development, 2011
Bmp represses Nodal signaling independently of lefty1 expression and through the activity of a ligand other than Bmp4.
Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish.
GeneRIF
Bakkers et al., Utrecht, Netherlands. In Plos Genet, 2011
both Nodal and Bmp independently are required for lefty1 expression to assure unilateral Nodal activation and correct LR patterning
Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.
GeneRIF
Tabibzadeh, Stony Brook, United States. In Ann N Y Acad Sci, 2011
Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation.
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