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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Leukocyte cell-derived chemotaxin 2

LECT2, leukocyte cell-derived chemotaxin 2, chondromodulin-II, ChM-II
This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, fibrillin-1, CAN, chondromodulin-I
Papers on LECT2
Gene expression profiling of bone marrow-derived stromal cells seeded onto a sandblasted, large-grit, acid-etched-treated titanium implant surface: The role of the Wnt pathway.
Guan et al., Hangzhou, China. In Arch Oral Biol, Jan 2016
RESULTS: A total of 19 genes were differentially expressed after SLA treatment, which included Apc2, Fzd1, Frzb, Wnt16, Fzd2, Plau, Wnt5b, Wnt5a, Lrp6, Wnt9a, Sfrp4, Prkch, Calcoco1, Ccnd1, Wif1, Fzd4, Myc, LRP5, and Lect2.
Leukocyte Cell-Derived Chemotaxin 2-Associated Amyloidosis: A Recently Recognized Disease with Distinct Clinicopathologic Characteristics.
Larsen et al., Little Rock, United States. In Clin J Am Soc Nephrol, Dec 2015
Amyloidosis derived from leukocyte cell-derived chemotaxin 2 is a recently recognized form of amyloidosis, and it has already been established as a frequent form of systemic amyloidosis in the United States, with predominant involvement of kidney and liver.
A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression.
Yoo et al., Seoul, South Korea. In Biochem Pharmacol, Dec 2015
Leukocyte cell-derived chemotaxin 2 (LECT2) is a recently discovered hepatokine that mediates obesity-related metabolic disturbances.
Renal LECT2 amyloidosis: a newly described disorder gaining greater recognition.
Lerma et al., In Clin Nephrol, Oct 2015
Recently, a new type of amyloidogenic protein was discovered, leukocyte chemotactic factor 2 (LECT2).
LECT2 induces atherosclerotic inflammatory reaction via CD209 receptor-mediated JNK phosphorylation in human endothelial cells.
Yoo et al., Seoul, South Korea. In Metabolism, Sep 2015
OBJECTIVE: Leukocyte cell-derived chemotaxin 2 (LECT2) is a recently discovered novel hepatokine, leading to skeletal muscle insulin resistance by activating c-Jun N-terminal kinase (JNK).
Interaction between smoking history and gene expression levels impacts survival of breast cancer patients.
Wittliff et al., Louisville, United States. In Breast Cancer Res Treat, Aug 2015
Using methods similar to Andres et al. (BMC Cancer 13:326, 2013a; Horm Cancer 4:208-221, 2013b), multivariable analyses revealed CENPN, CETN1, CYP1A1, IRF2, LECT2, and NCOA1 to be important predictors for both breast carcinoma recurrence and mortality among smokers.
[Leukocyte chemotactic factor 2 associated renal amyloidosis: one case report].
Zhang et al., Beijing, China. In Beijing Da Xue Xue Bao, May 2015
Here we report a case of leukocyte chemotactic factor 2 (LECT2)-associated renal amyloidosis (ALect2) in our hospital.
Globular hepatic amyloid is highly sensitive and specific for LECT2 amyloidosis.
Wu et al., New York City, United States. In Am J Surg Pathol, Apr 2015
LECT2 immunostaining was performed in 49 cases.
LECT2 improves the outcomes in ayu with Vibrio anguillarum infection via monocytes/macrophages.
Li et al., Ningbo, China. In Fish Shellfish Immunol, 2014
Leukocyte cell-derived chemotaxin 2 (LECT2) is reported to be a cytokine involved in the immune response against pathogenic microorganisms in fish.
Role of intestinal inflammation in predisposition of Edwardsiella tarda infection in zebrafish (Danio rerio).
Zhang et al., Shanghai, China. In Fish Shellfish Immunol, 2014
Furthermore, the expression of genes involved in neutrophil recruitment (mpx, IL-8 and LECT2) and antimicrobial response (β-defensin and hepcidin) showed notable up-regulation in the intestine of inflammatory zebrafish.
ALECT2 amyloidosis: a new type of systemic amyloid highly prevalent in the Hispanic population.
Leung et al., Calgary, Canada. In Rev Invest Clin, 2014
ALECT2 is a clinical entity characterized by deposition of the LECT2 protein mainly on liver and kidney.
Hepatic ALECT-2 amyloidosis causing portal hypertension and recurrent variceal bleeding: a case report and review of the literature.
How et al., Montréal, Canada. In Am J Clin Pathol, 2014
METHODS: One of the more recently reported proteins is ALECT-2 (leukocyte cell-derived chemotaxin 2) amyloid, found in renal specimens of Hispanic patients.
Leukocyte chemotactic factor 2 (LECT2) amyloidosis presenting as pulmonary-renal syndrome: a case report and review of the literature.
Wallace et al., Chicago, United States. In Clin Kidney J, 2013
Leukocyte chemotactic factor-2 (LECT2) amyloidosis has been described as being associated with kidney disease; however, no clinical manifestations outside of the kidney have been previously reported.
The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target.
Hui et al., Singapore, Singapore. In Cancer Gene Ther, 2011
Re-expression of LECT2 significantly reduced the migration and invasion of human hepatocellular carcinoma cells in vitro and significantly reduced their growth in vivo.
Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in d-galactosamine-sensitized mice.
Yagi et al., Tokyo, Japan. In Clin Immunol, 2010
Data suggest the involvement of LECT2 in the regulation of fatal SEA-induced toxicity in d-GalN-sensitized mice.
Leukocyte chemotactic factor 2 (LECT2)-associated renal amyloidosis: a case series.
Solomon et al., Knoxville, United States. In Am J Kidney Dis, 2010
LECT2-associated renal amyloidosis represents a unique and perhaps not uncommon disease, especially in Mexican Americans.
Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology.
Ohtomi et al., Funabashi, Japan. In Neuroreport, 2010
Our results suggest that LECT2 regulates neuritic extension through microtubular morphallaxis through the control of katanin-P60 levels.
Regulation of neurite extension by expression of LECT2 and neurotrophins based on findings in LECT2-knockout mice.
Ohtomi et al., Funabashi, Japan. In Brain Res, 2010
Our results show that LECT2 regulates the extension of axons and dendrites and the expressions of NGF, BDNF and NT-3 during neuronal development.
Neutrophil functions of patients with vasculitis related to myeloperoxidase-specific anti-neutrophil antibody.
Suzuki, Tokyo, Japan. In Int J Hematol, 2001
In addition, the reactivities of ANCA and inflammatory cytokines involving leukocyte-derived chemotaxin 2 (LECT2) are also discussed.
Roles of cartilage matrix proteins, chondromodulin-I and -II, in endochondral bone formation: a review.
Suzuki, Ōsaka, Japan. In Connect Tissue Res, 1995
Another cartilage-derived chondromodulin-II (ChM-II) also stimulates cartilage growth.
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