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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Leukocyte cell-derived chemotaxin 2

LECT2, leukocyte cell-derived chemotaxin 2, chondromodulin-II, ChM-II
This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on LECT2
The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target.
GeneRIF
Hui et al., Singapore, Singapore. In Cancer Gene Ther, 2011
Re-expression of LECT2 significantly reduced the migration and invasion of human hepatocellular carcinoma cells in vitro and significantly reduced their growth in vivo.
Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in d-galactosamine-sensitized mice.
GeneRIF
Yagi et al., Tokyo, Japan. In Clin Immunol, 2010
Data suggest the involvement of LECT2 in the regulation of fatal SEA-induced toxicity in d-GalN-sensitized mice.
Leukocyte chemotactic factor 2 (LECT2)-associated renal amyloidosis: a case series.
GeneRIF
Solomon et al., Knoxville, United States. In Am J Kidney Dis, 2010
LECT2-associated renal amyloidosis represents a unique and perhaps not uncommon disease, especially in Mexican Americans.
Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology.
GeneRIF
Ohtomi et al., Funabashi, Japan. In Neuroreport, 2010
Our results suggest that LECT2 regulates neuritic extension through microtubular morphallaxis through the control of katanin-P60 levels.
Regulation of neurite extension by expression of LECT2 and neurotrophins based on findings in LECT2-knockout mice.
GeneRIF
Ohtomi et al., Funabashi, Japan. In Brain Res, 2010
Our results show that LECT2 regulates the extension of axons and dendrites and the expressions of NGF, BDNF and NT-3 during neuronal development.
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