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Leucine zipper, down-regulated in cancer 1

LDOC1, leucine zipper down-regulated in cancer 1
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, PrP, SET, AGE
Papers on LDOC1
LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation.
New
Lin et al., Taipei, Taiwan. In Oncotarget, Oct 2015
By using integrated analysis of cDNA and methylation arrays of the smoking-associated dysplastic oral cell line and OSCC tumors, respectively, we identified four epigenetic targets--UCHL1, GPX3, LXN, and LDOC1--which may be silenced by cigarette.
LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-κB activation in papillary thyroid carcinoma.
Qin et al., Zhengzhou, China. In J Exp Clin Cancer Res, 2014
LDOC1 was first identified as a gene encoding a leucine zipper protein whose expression was decreased in a series of pancreatic and gastric cancer cell lines.
Epigenetic silencing of the LDOC1 tumor suppressor gene in ovarian cancer cells.
Jückstock et al., München, Germany. In Arch Gynecol Obstet, 2014
We analyzed the expression of the tumor suppressor candidate gene LDOC1 (leucine zipper downregulated in cancer 1) as a potential early biomarker in ovarian cancer cell lines.
Overexpression of LDOC1 in human biliary epithelial cells inhibits apoptosis through NF-κB signaling.
Zheng et al., Shanghai, China. In J Pediatr Gastroenterol Nutr, 2013
Leucine zipper downregulated in cancer 1 (LDOC1) may control the expression of NF-κB.
Loss of LDOC1 expression by promoter methylation in cervical cancer cells.
Brüning et al., München, Germany. In Cancer Invest, 2013
The expression of the LDOC1 tumor suppressor candidate was therefore investigated.
Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma.
Chang et al., Taiwan. In J Pathol, 2013
We identified BEX1 and LDOC1 as two epigenetically silenced X-linked tumour suppressors and demonstrated a functional link between the transcription of BEX1 and LDOC1 and promoter hypermethylation.
Two proapoptotic genes are downregulated in a patient with melanoma and repeated in-transit metastases.
GeneRIF
Calogero et al., In Am J Dermatopathol, 2012
Letter/Case Report: LDOC1/PARP1 are down-regulated in melanoma with repeated in-transit metastases.
LDOC1 gene expression in two patients with head and neck squamous cell carcinomas and Parkinson's disease.
Calogero et al., Enna, Italy. In Tumori, 2012
One of these genes is the leucine zipper, down-regulated in cancer 1 (LDOC1) gene.
Three apoptotic genes are upregulated in a patient with Alzheimer's disease and well-differentiated squamous cell carcinoma.
Calogero et al., Catania, Italy. In Int J Biol Markers, 2012
Also poly (ADP-ribose) polymerase 1 (PARP1) and the leucine zipper downregulated in cancer 1 (LDOC1) genes play a proapoptotic role.
Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma.
Teixeira et al., Porto, Portugal. In Plos One, 2011
We crossed a publicly available list of all putative EWSR1-FLI1 target genes in ESFT with our microarray expression data on 24 PCa and 6 non-malignant prostate tissues (NPT) and choose four genes among the top-most differentially expressed between PCa with (PCa ERG+) and without (PCa ETS-) ETS fusion genes (HIST1H4L, KCNN2, ECRG4 and LDOC1), as well as four well-validated direct targets of the EWSR1-FLI1 chimeric protein in ESFT (NR0B1, CAV1, IGFBP3 and TGFBR2).
Expression of LDOC1 mRNA in leucocytes of patients with Down's syndrome.
GeneRIF
Bosco et al., Italy. In J Genet, 2011
The aim of this study was to evaluate the possible differential expression of LDOC1 mRNA in leucocytes of peripheral blood of Down's syndrome subjects. compared with the normal population.
Over expression of LDOC1 and PARP1, two pro-apoptotic genes, in a patient with cryptorchidism and DiGeorge anomaly.
GeneRIF
Calogero et al., In Hum Cell, 2011
Over expression of LDOC1 may explain the clinical manifestation found in patients with cryptochidism and Digeorge anomaly.
LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patients.
GeneRIF
Abruzzo et al., Houston, United States. In Blood, 2011
LDOC1 is dramatically down-regulated in mutated chronic lymphocytic leukemia cases compared with unmutated cases, and have identified a new splice variant, LDOC1S
Sexy gene conversions: locating gene conversions on the X-chromosome.
Zhang et al., United States. In Nucleic Acids Res, 2009
We identified seven gene families (WD repeat protein family, Ferritin Heavy Chain family, RAS-related Protein RAB-40 family, Diphosphoinositol polyphosphate phosphohydrolase family, Transcription Elongation Factor A family, LDOC1-related family, Zinc Finger Protein ZIC, and GLI family) that show evidence of gene conversion.
A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data.
Pan et al., Taipei, Taiwan. In Bioinformatics, 2009
Identification of SLC4A5, SLC5A10 and LDOC1 indicated that sodium/bicarbonate transport, sodium/glucose transport and cell-proliferation regulation may play important upstream roles and identification of BNIP1, APOBEC3F and LDOC1 suggested that apoptosis, innate immune response and cell-proliferation regulation may play important downstream roles in hypertension.
Identification of candidate genes involved in the radiosensitivity of esophageal cancer cells by microarray analysis.
Fujii et al., Nagoya, Japan. In Dis Esophagus, 2007
The up-regulated genes included CABPR, FABP5, DSC2, GPX2, NME, CBR3, DOCK8, and ABCC5, while the down-regulated genes included RPA1, LDOC1, NDN, and SKP1A.
WAVE3 functions as a negative regulator of LDOC1.
Takenawa et al., Tokyo, Japan. In J Biochem, 2005
We found that LDOC1-encoded by a gene that is down-regulated in tumor cell lines-binds directly to the verprolin homology domain of WAVE3.
Identification of differentially expressed genes in psoriasis using expression profiling approaches.
Okubo et al., Mishima, Japan. In Exp Dermatol, 2005
We identified seven genes such as alpha-1-microglobulin/bikunin precursor, calnexin, claudin 1, leucine zipper down-regulated in cancer 1, tyrosinase-related protein 1, Yes-associated protein 1, and unc-13-like protein (Coleonyx elegans) which show high-expression levels only in uninvolved psoriatic lesions.
LDOC1, a novel MZF-1-interacting protein, induces apoptosis.
GeneRIF
Ra et al., Ōiso, Japan. In Febs Lett, 2005
MZF-1 was revealed to interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis
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