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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Component of oligomeric golgi complex 2

LDLC
This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: HAD, HDL, MEN, Apo, ACID
Papers on LDLC
Effect of mevalonic acid on cholesterol synthesis in bovine intramuscular and subcutaneous adipocytes.
New
Liu et al., China. In J Appl Genet, Jul 2015
The morphology of lipid accumulation of bovine preadipocytes was detected by Oil Red O staining, and total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and high-density lipoprotein cholesterol (HDLC) levels were measured.
Relationship between testosterone, estradiol and circulating PCSK9: Cross-sectional and interventional studies in humans.
New
Mayne et al., Ottawa, Canada. In Clin Chim Acta, Jul 2015
RESULTS: In men, (1) serum T does not correlate with circulating PCSK9 or with LDLC in the basal state, (2) T replacement therapy does not have any effect on circulating PCSK9, and (3) T ablation therapy has mixed results.
LOX-1 in atherosclerotic disease.
Review
New
Okamura et al., Matsumoto, Japan. In Clin Chim Acta, Mar 2015
We hypothesized that LOX-1 is a candidate risk factor beyond LDL cholesterol (LDLC) and developed a novel assay to quantify LOX-1 ligand containing apoB (LAB).
Feeding milk replacer instead of whole milk affects blood plasma proteome and lipid profile in preruminant calves.
Skrzypczak et al., In Pol J Vet Sci, 2014
Animals fed milk had a greater concentration of TC, HDLC and LDLC.
Lipoproteins, stroke and statins.
Review
Pende et al., Genova, Italy. In Curr Vasc Pharmacol, 2014
In this review, we want to point out the role of the different lipoproteins, such as triglycerides, HDL-C, LDLC, Lp(a), in the pathogenesis of stroke and the role of statins in reducing both lipid fractions and stroke risk.
Influence of dietary nicotinic acid supplementation on lipid metabolism and related gene expression in two distinct broiler breeds of female chickens.
Wen et al., In J Anim Physiol Anim Nutr (berl), 2014
Arbor Acres broilers had thickness of subcutaneous fat plus the skin (SFS), and plasma concentration of low-density lipoprotein cholesterol (LDLC) and lower percentage of abdominal fat (PAF), plasma concentrations of TG, NEFA and adiponectin than the BJY line.
[PCSK9 inhibitors and dyslipidemias: an update on clinical evidence].
Review
Norata, In G Ital Cardiol (rome), 2014
The inhibition of PCSK9 favors LDL catabolism and reduces plasma LDLC levels.
Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation.
Krauss et al., In Genome Biol, 2013
BACKGROUND: Statins are widely prescribed for lowering LDL-cholesterol (LDLC) levels and risk of cardiovascular disease.
Whole-exome sequencing in an extended family with myocardial infarction unmasks familial hypercholesterolemia.
Cardiogenics consortium et al., Lübeck, Germany. In Bmc Cardiovasc Disord, 2013
Sequencing of all family members available for genetic analysis revealed co-segregation of the variant with CAD (LOD 3.0) and increased LDLC (>190 mg/dL), following correction for statin treatment (LOD 4.3).
Lower levels of high-density lipoprotein cholesterol in urban Africans presenting with communicable versus non-communicable forms of heart disease: the 'Heart of Soweto' hospital registry study.
Stewart et al., Adelaide, Australia. In Bmj Open, 2013
years) had fasting blood lipid levels (total cholesterol (TC), triglyceride, HDLC and low-density lipoprotein cholesterol (LDLC)) documented on admission.
Increased cardiovascular risk in South African patients with Addison's disease.
Marais et al., Cape Town, South Africa. In Horm Metab Res, 2013
had a higher LDLC.
Haematological and serum biochemical responses of chickens to hydric stress.
Chimonyo et al., Durban, South Africa. In Animal, 2013
Packed cell volume (PCV), erythrocyte count (RBC), mean corpuscular volume (MCV) and total leucocyte count (WBC), and biochemical parameters (uric acid (UA)), creatinine (CREAT), total protein (TP), albumin (ALB), globulin (GLOB), triglyceride (TGA), total cholesterol (TC), high- (HDLC) and low- (LDLC) density lipoprotein cholesterol and activity of alanine transaminase (ALT), alkaline phosphatase (ALP) and aspartate transaminase (AST) were determined from blood collected after 60 days of water restriction.
Hepatitis C virus and lipids in the era of direct acting antivirals (DAAs).
Review
Bassendine et al., Newcastle upon Tyne, United Kingdom. In Clin Res Hepatol Gastroenterol, 2013
Several host factors associated with response to pegylated interferon-α and ribavirin are not as important in predicting response to triple therapy, and yet low-density lipoprotein cholesterol (LDLC) and statin use remain important associations of outcome with DAAs.
Antihyperlipidemic and antiatherogenic activity of simvastatin may involve modulation of the expression of lecithin:cholesterol acyl transferase.
Adelusi et al., Nigeria. In Acta Biochim Pol, 2012
Simvastatin caused a significant reduction in the atherogenic index (TC/HDL-C; LDLC/HDL-C).
Molecular pathways and agents for lowering LDL-cholesterol in addition to statins.
Review
Costet, Nantes, France. In Pharmacol Ther, 2010
Recent guidelines in North America and Europe recommend lowering low density lipoprotein associated cholesterol (LDLC) to achieve optimal coronary heart disease risk reduction.
The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.
GeneRIF
Ikehara et al., Fukuoka, Japan. In Traffic, 2007
The interaction between p115 and Cog2 was found to be essential for Golgi ribbon reformation after the disruption of the ribbon by p115 KD or brefeldin A treatment and recovery by re-expression of p115 or drug wash out, respectively.
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