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Lactate dehydrogenase B

LDH-B, lactate dehydrogenase B, LDH2
This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: LDH-X, ACID, HAD, CAN, fibrillin-1
Papers on LDH-B
Antibodies against Clonorchis sinensis LDH could cross-react with LDHB localizing on the plasma membrane of human hepatocarcinoma cell SMMC-7721 and induce apoptosis.
Hu et al., Guangzhou, China. In Parasitol Res, Feb 2016
UNASSIGNED: Lactate dehydrogenase (LDH) is a terminal enzyme in anaerobic glycolytic pathway.
Molecular changes in mitochondrial respiratory activity and metabolic enzyme activity in muscle of four pig breeds with distinct metabolic types.
Ponsuksili et al., Germany. In J Bioenerg Biomembr, Feb 2016
At the transcriptional level, lactate dehydrogenase B showed breed specificity, with significantly lower expression in Pietrain pigs homozygous-positive for malignant hyperthermia syndrome.
RPS7 inhibits colorectal cancer growth via decreasing HIF-1α-mediated glycolysis.
Wang et al., Shanghai, China. In Oncotarget, Jan 2016
In this study, we demonstrate that RPS7 inhibits the colorectal cancer (CRC) cell glycolysis by suppressing the expression of hypoxia-inducible transcription factor-1α (HIF-1α) and the metabolic promoting proteins glucose transporter 4 (GLUT4) and lactate dehydrogenase B (LDHB).
Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival.
Wanner et al., Los Angeles, United States. In Glia, Jan 2016
STAT3-CKO astrocytes had reduced basal expression of GFAP, lactate dehydrogenase B (LDHB), aldolase C (ALDOC), and astrocytic phosphoprotein 15 (PEA15), and elevated levels of tropomyosin (TPM4) and α actinin 4 (ACTN4).
Enzymatic Kinetic Properties of the Lactate Dehydrogenase Isoenzyme C₄ of the Plateau Pika (Ochotona curzoniae).
Wei et al., Xining, China. In Int J Mol Sci, Dec 2015
The pure enzymes of Lactate Dehydrogenase A₄ (LDH-A₄), Lactate Dehydrogenase B₄ (LDH-B₄), and LDH-C₄ were prepared by a series of expression and purification processes, and the three enzymes were identified by the method of sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and native polyacrylamide gel electrophoresis (PAGE).
Cancer metabolism and mass spectrometry-based proteomics.
Petricoin et al., Manassas, United States. In Cancer Lett, Feb 2015
In addition, MS analyses from pancreatic cancer cells demonstrate that lactate dehydrogenase-B is significantly upregulated in pancreatic cancer cells, whereas previous reports show that lactate dehydrogenase-A is overexpressed and is responsible for lactate production in cancer cells.
Evaluation of multiple serum markers in advanced melanoma.
González et al., Pamplona, Spain. In Tumour Biol, 2011
Results show that S-100B, MIA and LDH levels were significantly higher in patients with advanced melanoma than in disease-free patients or healthy controls.
Loss of lactate dehydrogenase B subunit expression is correlated with tumour progression and independently predicts inferior disease-specific survival in urinary bladder urothelial carcinoma.
Wu et al., Kao-hsiung, Taiwan. In Pathology, 2011
results confirmed the prognostic roles of LDH-B in urinary bladder urothelial carcinoma.
The role of LDH serum levels in predicting global outcome in HCC patients undergoing TACE: implications for clinical management.
Cascinu et al., Ancona, Italy. In Plos One, 2011
Data indicate that serum lactate dehydrogenase (LDH) seemed able to predict clinical outcome for hepatocellular carcinoma (HCC) patients undergoing hepatocellular carcinoma (HCC).
Serum creatine kinase and lactate dehydrogenase activities in patients with thyroid disorders.
Rawlins et al., Kingston, Jamaica. In Niger J Clin Pract, 2011
The significant elevation in serum CK [creatine kinase ]and LDH [L-Lactate Dehydrogenase ] activities indicates that these can be used as parameters for screening hypothyroid patients but not hyperthyroid patients.
Circadian rhythm of metabolic oscillation in suprachiasmatic nucleus depends on the mitochondrial oxidation state, reflected by cytochrome C oxidase and lactate dehydrogenase.
Nishino et al., Nagoya, Japan. In J Neurosci Res, 2011
LDH and its coding mRNA were higher during the dark period.
[Significance of lactate dehydrogenase measurements in diagnosis of malignancies].
Grabowski et al., Laizhou, China. In Pol Merkur Lekarski, 2004
Each isoenzyme is a tetrametric composition of two subunits, A(M) and B(H), encoded by separate genes (Ldh-A and Ldh-B respectively).
Environmental adaptations as windows on molecular evolution.
Schulte, Waterloo, Canada. In Comp Biochem Physiol B Biochem Mol Biol, 2001
We have determined the mechanism responsible for changes in lactate dehydrogenase-B (Ldh-B) gene regulation.
Methods for the separation of lactate dehydrogenases and clinical significance of the enzyme.
Kirchberger et al., Leipzig, Germany. In J Chromatogr B Biomed Appl, 1996
In mammals, three types of subunits encoded by the genes Ldh-A, Ldh-B and Ldh-C give rise to a selected number of tetrameric isoenzymes.
Recruitment of enzymes and stress proteins as lens crystallins.
Tomarev et al., Bethesda, United States. In Exs, 1993
Some crystallins have been recruited without duplication of the original gene (i.e., lactate dehydrogenase B and alpha-enolase), while others have incurred one (i.e., argininosuccinate lyase and a small heat shock protein) or several (i.e., glutathione S-transferase) gene duplications.
Physiological basis for swimming endurance differences between LDH-B genotypes of Fundulus heteroclitus.
Powers et al., In Science, 1982
Adenosine triphosphate levels in erythrocytes are correlated with LDH-B genotype in Fundulus heteroclitus.
Centric fusion and trisomy for the LDH-B locus in brook trout, Salvelinus fontinalis.
Atherton et al., In Science, 1973
Cytogenetic analyses showed that a trisomic male brook trout of genotype BB'B'' for one of the lactate dehydrogenase subunit loci had a karyotype with two extra arms appearing as a metacentric chromosome.
Homology of lactate dehydrogenase genes: E gene function in the teleost nervous system.
Whitt, In Science, 1969
Immunochemical and other studies demonstrate that this third locus is closely related to the lactate dehydrogenase B locus.
Linkage of lactate dehydrogenase B and C loci in pigeons.
Renwick et al., In Science, 1969
Synthesis of lactate dehydrogenase in somatic and gametic tissues of certain avian and mammalian species is controlled by alleles at three loci, A, B, and C. We report breeding experiments with pigeons that conclusively demonstrate linkage between the B and C structural loci in this species.
NEELY et al., In Science, 1964
One of these is similar to the one previously described by Boyer and is interpreted as a variant of LDH-B.
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