gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

LIM domain binding 1

Ldb1, NLI, CLIM2
Top mentioned proteins: LIM, LMO2, LIM-only, CAN, LMO4
Papers on Ldb1
Low-Grade Inflammation and Increased Arterial Stiffness in Chinese Youth and Adolescents with Newly-Diagnosed Type 2 Diabetes Mellitus.
New
Sun et al., Wuhan, China. In J Clin Res Pediatr Endocrinol, 05 Jan 2016
The subjects were divided into a non-LI group (NLI, n=42) and a LI group (n=56) according to their high-sensitivity C-reactive protein (Hs-CRP) levels.
LMO2 Oncoprotein Stability in T-cell Leukemia Requires Direct LDB1 Binding.
New
Davé et al., Nashville, United States. In Mol Cell Biol, 23 Dec 2015
In this study we systematically dissected the LMO2/LDB1 binding interface to investigate the role of this interaction in T-cell leukemia.
Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping.
New
Miller et al., Bethesda, United States. In Blood, Aug 2015
Transcription of β-globin genes is regulated by the distant locus control region (LCR), which is brought into direct gene contact by the LDB1/GATA-1/TAL1/LMO2-containing complex.
Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program.
New
Rosenfeld et al., Hefei, China. In Proc Natl Acad Sci U S A, Mar 2015
Here we report the required actions of LIM domain-binding protein 1 (LDB1)/cofactor of LIM homeodomain protein 2/nuclear LIM interactor, interacting with the enhancer-binding protein achaete-scute complex homolog 1, to mediate looping to target gene promoters and target gene regulation in corticotrope cells.
Control of developmentally primed erythroid genes by combinatorial co-repressor actions.
Soler et al., Rotterdam, Netherlands. In Nat Commun, 2014
Here we show that the key haematopoietic LIM-domain-binding protein-1 (LDB1) TF complex contains several activator and repressor components that together maintain an erythroid-specific gene expression programme primed for rapid activation until differentiation is induced.
Early stages of induction of anterior head ectodermal properties in Xenopus embryos are mediated by transcriptional cofactor ldb1.
Grainger et al., United States. In Dev Dyn, 2014
RESULTS: Using an expression cloning strategy to isolate genes with lens-inducing activity, we identified the transcriptional cofactor ldb1.
Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.
Nagarajan et al., Houston, United States. In J Immunol, 2014
SSBP2 binds the transcriptional adaptor protein Lim domain-binding protein 1 (LDB1) and enhances LDB1 stability to regulate gene expression.
The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.
Andersen et al., Irvine, United States. In Plos Genet, 2014
We explored these mechanisms in the basal cell compartment and identified the Co-factor of LIM domains (CLIM/LDB/NLI) as a transcriptional regulator that maintains these cells.
Role of LDB1 in the transition from chromatin looping to transcription activation.
Dean et al., Bethesda, United States. In Genes Dev, 2014
In erythroid cells, lim domain binding 1 (LDB1) protein is recruited to the β-globin locus via LMO2 and is required for looping of the β-globin locus control region (LCR) to the active β-globin promoter.
A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].
Jackson et al., Edinburgh, United Kingdom. In Plos Genet, 2014
Co-immunoprecipitation experiments show that both wild-type and Icst LMX1B are found in complexes with LIM domain binding protein 1 (LDB1), resulting in lower levels of functional LMX1B in Icst heterozygotes than null heterozygotes.
The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.
Matthews et al., Sydney, Australia. In Plos One, 2013
We used yeast two-hybrid assays to show that DEAF1 binds both LIM domains of LMO4 and that DEAF1 binds the same face on LMO4 as two other LMO4-binding partners, namely LIM domain binding protein 1 (LDB1) and C-terminal binding protein interacting protein (CtIP/RBBP8).
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Impact
Cho et al., Cambridge, United States. In Nature, 2012
Recurrent somatic mutations were newly identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR and LDB1.
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Impact
GeneRIF
Blobel et al., Philadelphia, United States. In Cell, 2012
Findings establish Ldb1 as a critical effector of GATA1-mediated loop formation and indicate that chromatin looping causally underlies gene regulation.
Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells.
GeneRIF
Dean et al., Bethesda, United States. In Blood, 2012
We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin locus in human erythroid cells.
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.
Impact
GeneRIF
Love et al., Bethesda, United States. In Nat Immunol, 2011
controls transcriptional program required for stem cells maintenance by restricting their differentiation
Liver-specific Ldb1 deletion results in enhanced liver cancer development.
GeneRIF
Galle et al., Mainz, Germany. In J Hepatol, 2010
knockout mice demonstrated a significantly enhanced growth of liver cancer (HCC) by means of tumor size and number, advocating for an essential role of Ldb1 in HCC development
A requirement for Lim domain binding protein 1 in erythropoiesis.
GeneRIF
Love et al., Bethesda, United States. In J Exp Med, 2010
a role for Ldb1 in erythropoiesis in vivo and establish a critical function for Ldb1-nucleated complexes in regulating the erythroid/megakaryocyte transcriptional program.
LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.
Impact
Pfaff et al., Los Angeles, United States. In Cell, 2002
Using in vivo function and protein interaction assays, we found that Lhx3 binds directly to the LIM cofactor NLI to trigger V2 interneuron differentiation.
Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.
Impact
Bach et al., Hamburg, Germany. In Nature, 2002
LIM homeodomain (LIM-HD) transcription factors associate with RLIM (RING finger LIM domain-binding protein) and with CLIM (cofactor of LIM-HD proteins; also known as NLI, Ldb and Chip) cofactors.
RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.
Impact
Rosenfeld et al., San Diego, United States. In Nat Genet, 1999
The inhibitory actions of the LIM domain can often be overcome by the LIM co-regulator known as CLIM2, LDB1 and NLI (referred to hereafter as CLIM2; refs 2-4).
share on facebooktweetadd +1mail to friends