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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

LIM domain binding 1

Ldb1, NLI, CLIM2
Top mentioned proteins: LIM, LMO2, LIM-only, CAN, LMO4
Papers on Ldb1
Mechanism governing a stem cell-generating cis-regulatory element.
New
Bresnick et al., Madison, United States. In Proc Natl Acad Sci U S A, Apr 2014
Loss-of-function analyses provided evidence for a mechanism in which a mediator of long-range transcriptional control [LIM domain binding 1 (LDB1)] and a chromatin remodeler [Brahma related gene 1 (BRG1)] synergize through the +9.5 site, conferring expression of GATA-2, which is known to promote the genesis and survival of hematopoietic stem cells.
Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation.
New
Jeong et al., New York City, United States. In Bmc Dev Biol, Dec 2013
BACKGROUND: LIM domain binding protein 1 (LDB1) is a transcriptional co-factor, which interacts with multiple transcription factors and other proteins containing LIM domains.
Elucidation of the role of LMO2 in human erythroid cells.
New
Harigae et al., Sendai, Japan. In Exp Hematol, Dec 2013
LIM-only protein 2 (LMO2) is a non-DNA-binding component of a protein complex containing master regulators of hematopoiesis, including GATA-1, SCL/TAL1, and LDB1.
Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets.
New
Mancini et al., Oxford, United Kingdom. In Cell Rep, Aug 2013
One such complex, which contains the basic-helix-loop-helix heterodimer SCL:E47 and bridging proteins LMO2:LDB1, critically regulates hematopoiesis and induces T cell leukemia.
Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.
New
Matthews et al., Sydney, Australia. In J Mol Biol, May 2013
Our data reveal that CtIP and the essential LMO cofactor LDB1 (LIM-domain binding protein 1) bind to the same face on LMO4 and cannot simultaneously bind to LMO4.
Role of transcriptional corepressor ETO2 in erythroid cells.
New
Harigae et al., Sendai, Japan. In Exp Hematol, Mar 2013
Transcriptional corepressor ETO2 is a component of a protein complex containing master regulators of hematopoiesis, including GATA-1, SCL/TAL1, LMO2, and LDB1.
Suspected leukemia oncoproteins CREB1 and LYL1 regulate Op18/STMN1 expression.
Minden et al., Toronto, Canada. In Biochim Biophys Acta, 2012
NLI, LMO2 and GATA2 are previously described co-activators of Tal1/Lyl1-E47 transcriptional complexes and potentiate Lyl1 activation of the STMN1 promoter while having no effect on TAL1 transactivation.
A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cells.
Grosveld et al., Rotterdam, Netherlands. In Mol Cell Biol, 2012
RUNX1 has been shown to be part of a large transcription factor complex, together with LDB1, GATA1, TAL1, and ETO2 (N.
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Impact
Cho et al., Cambridge, United States. In Nature, 2012
Recurrent somatic mutations were newly identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR and LDB1.
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Impact
GeneRIF
Blobel et al., Philadelphia, United States. In Cell, 2012
Findings establish Ldb1 as a critical effector of GATA1-mediated loop formation and indicate that chromatin looping causally underlies gene regulation.
Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.
Lossos et al., Miami, United States. In Blood, 2012
In DLBCL, the LMO2 complex contains some of the traditional partners, such as LDB1, E2A, HEB, Lyl1, ETO2, and SP1, but not TAL1 or GATA proteins.
Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells.
GeneRIF
Dean et al., Bethesda, United States. In Blood, 2012
We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin locus in human erythroid cells.
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.
Impact
GeneRIF
Love et al., Bethesda, United States. In Nat Immunol, 2011
controls transcriptional program required for stem cells maintenance by restricting their differentiation
Liver-specific Ldb1 deletion results in enhanced liver cancer development.
GeneRIF
Galle et al., Mainz, Germany. In J Hepatol, 2010
knockout mice demonstrated a significantly enhanced growth of liver cancer (HCC) by means of tumor size and number, advocating for an essential role of Ldb1 in HCC development
A requirement for Lim domain binding protein 1 in erythropoiesis.
GeneRIF
Love et al., Bethesda, United States. In J Exp Med, 2010
a role for Ldb1 in erythropoiesis in vivo and establish a critical function for Ldb1-nucleated complexes in regulating the erythroid/megakaryocyte transcriptional program.
Decoding the LIM development code.
Review
Gill, In Trans Am Clin Climatol Assoc, 2002
The basic code is a homotetramer of 2 LIM homeodomain proteins bridged by the adaptor protein, nuclear LIM interactor (NLI).
A short history of LIM domains (1993-2002): from protein interaction to degradation.
Review
Bachy et al., Gif-sur-Yvette, France. In Mol Neurobiol, 2002
In this review, the authors describe the progressive discoveries of NLI/Ldb/CLIM, LMO and RLIM, and discuss how the field was very recently updated by the finding that LIM-hd transcriptional activity is controlled by regulated degradation of cofactors and LIM-hd themselves.
LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.
Impact
Pfaff et al., Los Angeles, United States. In Cell, 2002
Using in vivo function and protein interaction assays, we found that Lhx3 binds directly to the LIM cofactor NLI to trigger V2 interneuron differentiation.
Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.
Impact
Bach et al., Hamburg, Germany. In Nature, 2002
LIM homeodomain (LIM-HD) transcription factors associate with RLIM (RING finger LIM domain-binding protein) and with CLIM (cofactor of LIM-HD proteins; also known as NLI, Ldb and Chip) cofactors.
RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.
Impact
Rosenfeld et al., San Diego, United States. In Nat Genet, 1999
The inhibitory actions of the LIM domain can often be overcome by the LIM co-regulator known as CLIM2, LDB1 and NLI (referred to hereafter as CLIM2; refs 2-4).
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