Mechanism governing a stem cell-generating cis-regulatory element.
Madison, United States. In Proc Natl Acad Sci U S A, Apr 2014
Loss-of-function analyses provided evidence for a mechanism in which a mediator of long-range transcriptional control [LIM domain binding 1 (LDB1)] and a chromatin remodeler [Brahma related gene 1 (BRG1)] synergize through the +9.5 site, conferring expression of GATA-2, which is known to promote the genesis and survival of hematopoietic stem cells.
Decoding the LIM development code.
In Trans Am Clin Climatol Assoc, 2002
The basic code is a homotetramer of 2 LIM homeodomain proteins bridged by the adaptor protein, nuclear LIM interactor (NLI).