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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

LIM domain binding 1

Ldb1, NLI, CLIM2
Top mentioned proteins: LIM, LMO2, LIM-only, CAN, LMO4
Papers on Ldb1
Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.
New
Nagarajan et al., Houston, United States. In J Immunol, 01 Dec 2014
SSBP2 binds the transcriptional adaptor protein Lim domain-binding protein 1 (LDB1) and enhances LDB1 stability to regulate gene expression.
Early stages of induction of anterior head ectodermal properties in Xenopus embryos are mediated by transcriptional cofactor ldb1.
New
Grainger et al., United States. In Dev Dyn, 25 Oct 2014
Results: Using an expression cloning strategy to isolate genes with lens-inducing activity, we identified the transcriptional cofactor ldb1.
The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.
New
Andersen et al., Irvine, United States. In Plos Genet, Jul 2014
We explored these mechanisms in the basal cell compartment and identified the Co-factor of LIM domains (CLIM/LDB/NLI) as a transcriptional regulator that maintains these cells.
Role of LDB1 in the transition from chromatin looping to transcription activation.
New
Dean et al., Bethesda, United States. In Genes Dev, Jul 2014
In erythroid cells, lim domain binding 1 (LDB1) protein is recruited to the β-globin locus via LMO2 and is required for looping of the β-globin locus control region (LCR) to the active β-globin promoter.
A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LBD1-mediated dimerisation.
New
Jackson et al., Edinburgh, United Kingdom. In Plos Genet, May 2014
Co-immunoprecipitation experiments show that both wild-type and Icst LMX1B are found in complexes with LIM domain binding protein 1 (LDB1), resulting in lower levels of functional LMX1B in Icst heterozygotes than null heterozygotes.
Mechanism governing a stem cell-generating cis-regulatory element.
New
Bresnick et al., Madison, United States. In Proc Natl Acad Sci U S A, Apr 2014
Loss-of-function analyses provided evidence for a mechanism in which a mediator of long-range transcriptional control [LIM domain binding 1 (LDB1)] and a chromatin remodeler [Brahma related gene 1 (BRG1)] synergize through the +9.5 site, conferring expression of GATA-2, which is known to promote the genesis and survival of hematopoietic stem cells.
Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation.
New
Jeong et al., New York City, United States. In Bmc Dev Biol, Dec 2013
BACKGROUND: LIM domain binding protein 1 (LDB1) is a transcriptional co-factor, which interacts with multiple transcription factors and other proteins containing LIM domains.
Elucidation of the role of LMO2 in human erythroid cells.
New
Harigae et al., Sendai, Japan. In Exp Hematol, Dec 2013
LIM-only protein 2 (LMO2) is a non-DNA-binding component of a protein complex containing master regulators of hematopoiesis, including GATA-1, SCL/TAL1, and LDB1.
The Structure of an LIM-Only Protein 4 (LMO4) and Deformed Epidermal Autoregulatory Factor-1 (DEAF1) Complex Reveals a Common Mode of Binding to LMO4.
New
Matthews et al., Sydney, Australia. In Plos One, Dec 2013
We used yeast two-hybrid assays to show that DEAF1 binds both LIM domains of LMO4 and that DEAF1 binds the same face on LMO4 as two other LMO4-binding partners, namely LIM domain binding protein 1 (LDB1) and C-terminal binding protein interacting protein (CtIP/RBBP8).
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Impact
Cho et al., Cambridge, United States. In Nature, 2012
Recurrent somatic mutations were newly identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR and LDB1.
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Impact
GeneRIF
Blobel et al., Philadelphia, United States. In Cell, 2012
Findings establish Ldb1 as a critical effector of GATA1-mediated loop formation and indicate that chromatin looping causally underlies gene regulation.
Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells.
GeneRIF
Dean et al., Bethesda, United States. In Blood, 2012
We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin locus in human erythroid cells.
Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.
Impact
GeneRIF
Love et al., Bethesda, United States. In Nat Immunol, 2011
controls transcriptional program required for stem cells maintenance by restricting their differentiation
Liver-specific Ldb1 deletion results in enhanced liver cancer development.
GeneRIF
Galle et al., Mainz, Germany. In J Hepatol, 2010
knockout mice demonstrated a significantly enhanced growth of liver cancer (HCC) by means of tumor size and number, advocating for an essential role of Ldb1 in HCC development
A requirement for Lim domain binding protein 1 in erythropoiesis.
GeneRIF
Love et al., Bethesda, United States. In J Exp Med, 2010
a role for Ldb1 in erythropoiesis in vivo and establish a critical function for Ldb1-nucleated complexes in regulating the erythroid/megakaryocyte transcriptional program.
Decoding the LIM development code.
Review
Gill, In Trans Am Clin Climatol Assoc, 2002
The basic code is a homotetramer of 2 LIM homeodomain proteins bridged by the adaptor protein, nuclear LIM interactor (NLI).
A short history of LIM domains (1993-2002): from protein interaction to degradation.
Review
Bachy et al., Gif-sur-Yvette, France. In Mol Neurobiol, 2002
In this review, the authors describe the progressive discoveries of NLI/Ldb/CLIM, LMO and RLIM, and discuss how the field was very recently updated by the finding that LIM-hd transcriptional activity is controlled by regulated degradation of cofactors and LIM-hd themselves.
LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.
Impact
Pfaff et al., Los Angeles, United States. In Cell, 2002
Using in vivo function and protein interaction assays, we found that Lhx3 binds directly to the LIM cofactor NLI to trigger V2 interneuron differentiation.
Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.
Impact
Bach et al., Hamburg, Germany. In Nature, 2002
LIM homeodomain (LIM-HD) transcription factors associate with RLIM (RING finger LIM domain-binding protein) and with CLIM (cofactor of LIM-HD proteins; also known as NLI, Ldb and Chip) cofactors.
RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.
Impact
Rosenfeld et al., San Diego, United States. In Nat Genet, 1999
The inhibitory actions of the LIM domain can often be overcome by the LIM co-regulator known as CLIM2, LDB1 and NLI (referred to hereafter as CLIM2; refs 2-4).
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