Femtosecond crystallography of membrane proteins in the lipidic cubic phase.
Los Angeles, United States. In Philos Trans R Soc Lond B Biol Sci, 2014
During the past two years, crystallization in lipidic cubic phase (LCP) has started gaining a widespread acceptance, owing to the spectacular success in high-resolution structure determination of G protein-coupled receptors (GPCRs) and to the introduction of commercial instrumentation, tools and protocols.
GPCR crystallization using lipidic cubic phase technique.
Xinpu, China. In Curr Pharm Biotechnol, 2013
Recently, the development and application of lipidic cubic phase (LCP) technology has reduced one major hurdle for crystallization of GPCRs, with 22 unique receptors being structurally characterized from LCP grown crystals over the span of seven years.
Prion strain discrimination using luminescent conjugated polymers.
Zürich, Switzerland. In Nat Methods, 2007
LCP reactivity and emission spectra of brain sections discriminated among four immunohistochemically indistinguishable, serially mouse-passaged prion strains derived from sheep scrapie, chronic wasting disease (CWD), bovine spongiform encephalopathy (BSE), and mouse-adapted Rocky Mountain Laboratory scrapie prions.