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Lymphocyte-specific protein tyrosine kinase

Lck, p56lck, Protein-Tyrosine Kinase
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Src, CAN, CD4, ZAP-70, V1a
Papers using Lck antibodies
Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer.
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Chandra Dhyan, In PLoS ONE, 2009
... Lck-Casp9DN transgenic mice were genotyped by ...
Notch dimerization is required for leukemogenesis and T-cell development.
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Alberola-Ila Jose, In PLoS ONE, 2009
... Lck-Cre transgenic mice as previously described ...
Interstitial leukocyte migration and immune function
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Griffiths Gillian M et al., In European Journal of Immunology, 2007
... were: rabbit anti-γ-tubulin (Sigma-Aldrich), anti-lamin B1 (Abcam), and anti-actin (Sigma-Aldrich); mouse anti-γ-tubulin (clone TU-30, Abcam), anti-Lck (clone 3a5, Millipore), and anti-pT538-PKCθ (clone 19/PKC, BD Biosciences); sheep anti-GFP (AbD Serotec); ...
Public T cell receptor beta-chains are not advantaged during positive selection
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Crompton Tessa et al., In European Journal of Immunology, 2007
... Lck-Gli2ΔC2 (C2, Gli2R) 24 transgenic mice and HY-TCR transgenic ...
The cytoplasmic tail of CD45 is released from activated phagocytes and can act as an inhibitory messenger for T cells.
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Fritz Jörg Hermann, In PLoS ONE, 2007
... Rabbit polyclonal antibodies to phospho-Lck (Tyr505) and Lck were obtained from Cell Signaling Technology (Beverly, MA) ...
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Papers on Lck
Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis.
New
Rafei et al., Montréal, Canada. In Aging Cell, Feb 2016
As a result, stimulation of T cells derived from rIL-21-treated aged mice displayed enhanced activation of Lck, ZAP-70, and ERK, which ultimately boosted their IL-2 production, CD25 expression, and proliferation capabilities in comparison with T cells derived from control aged mice.
T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion.
New
Gallagher et al., London, United Kingdom. In Cell Rep, Feb 2016
To better understand the role of Mekk1 (encoded by Map3k1) in T cells, we conditionally deleted Map3k1 in Lck(Cre/+)Map3k1(f/f) mice, and these display larger iNKT cell populations within the liver, spleen, and bone marrow.
Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases.
Review
New
Levite, Jerusalem, Israel. In Acta Physiol (oxf), Jan 2016
ERK, Lck, Fyn, NF-κB, KLF2), (x) T cells produce dopamine (Tregs>>>Teffs), can release dopamine, mainly after activation (by antigen, mitogen, anti-CD3 antibodies, PKC activators or other), uptake extracellular dopamine, and most probably need dopamine, (xi) dopamine is important for antigen-specific interactions between T cells and dendritic cells, (xii) in few autoimmune diseases (e.g.
Construction of an immunorelated protein-protein interaction network for clarifying the mechanism of burn.
New
Wang et al., Guangzhou, China. In Burns, Jan 2016
The PPI network and module analysis revealed that, 1 day after the burn, lymphocyte-specific protein tyrosine kinase (Lck) (downregulated), Jun (upregulated), Cd19 (downregulated), Stat1 (downregulated), and Cdk1 (upregulated) were located centrally in both the PPI network and modules.
[Screening genes related with leukocyte responses early after burn injury: analysis of differentially gene expression profiling data in mice].
New
Yang et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, Jan 2016
PPI network and module analysis suggested that some of genes (such as Lck, Stat1, Myd88, Stat3, and Jun) play critical roles in the PPI network post-burn.
How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions.
Review
New
Arold et al., Saudi Arabia. In Prog Biophys Mol Biol, Oct 2015
The focal adhesion kinase (FAK) and the related protein-tyrosine kinase 2-beta (Pyk2) are highly versatile multidomain scaffolds central to cell adhesion, migration, and survival.
T cell receptor dwell times control the kinase activity of Zap70.
New
Impact
Lillemeier et al., Los Angeles, United States. In Nat Immunol, Sep 2015
Parallel recruitment of coreceptor-associated Lck kinase to the TCR ensured Zap70 phosphorylation and stabilized Zap70 TCR binding.
Genomic Classification of Cutaneous Melanoma.
New
Impact
Cancer Genome Atlas Network, In Cell, Jul 2015
We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival.
[Construction of expression vector pLCK-CD69-IRES-EGFP and generation of CD69 transgenic mice].
New
Hui-Ying et al., Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, Jun 2015
Second, this DNA fragment was subcloned to the pInsulater-LCK-IRES-EGFP plasmid and constructed the transgenic vector after the verification of nucleotide sequence.
Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors.
Review
New
Roskoski, United States. In Pharmacol Res, Apr 2015
The physiological Src proto-oncogene is a protein-tyrosine kinase that plays key roles in cell growth, division, migration, and survival signaling pathways.
Fyn in Neurodevelopment and Ischemic Brain Injury.
Review
Jiang et al., New York City, United States. In Dev Neurosci, 2014
The SFKs Fyn, Src, Yes, Lyn, and Lck are expressed in the brain.
The role of dasatinib in the management of chronic myeloid leukemia.
Review
Chen et al., Nanjing, China. In Drug Des Devel Ther, 2014
It potently inhibits BCR/ABL and SRC-family kinases (SRC, LCK, HCK, YES, FYN, FGR, BLK, LYN, FRK), as well as c-KIT, PDGFR-a and -b, and ephrin receptor kinase.
N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²⁺ signaling.
Impact
Demetriou et al., Irvine, United States. In Nat Immunol, 2014
N-glycan branching was required for positive selection and decoupled Lck signaling from TCR-driven Ca(2+) flux to simultaneously promote low-affinity peptide-MHC responses while inhibiting high-affinity ones.
Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.
Impact
Palmer et al., Basel, Switzerland. In Cell, 2014
We show that very few CD4 or CD8 coreceptor molecules are coupled with the signal-initiating kinase, Lck.
Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Impact
Malarkannan et al., Milwaukee, United States. In Nat Immunol, 2013
Both of those effector functions required the kinases Lck, Fyn and PI(3)K (subunits p85α and p110δ) and the signaling protein PLC-γ2.
Cytoskeletal modulation of lipid interactions regulates Lck kinase activity.
GeneRIF
Rodgers et al., Oklahoma City, United States. In J Biol Chem, 2012
Data show that cytoskeletal modulation of lipid interactions regulates Lck kinase activity.
Stage I non-small cell lung cancer: the presence of the lymphocyte-specific protein tyrosin kinase in the tumour infiltrate is associated with a better long-term prognosis.
GeneRIF
Rendina et al., Roma, Italy. In Interact Cardiovasc Thorac Surg, 2012
LCK-positive tumour infiltrate is associated with a significantly longer overall survival and time to relapse in patients with radically resected stage I NSCLC.
Lymphocyte cell kinase activation mediates neuroprotection during ischemic preconditioning.
GeneRIF
Majid et al., East Lansing, United States. In J Neurosci, 2012
results show that Lck plays an essential role in PC in both cellular and animal models of stroke.
Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex.
GeneRIF
Conforti et al., Cincinnati, United States. In Am J Physiol Cell Physiol, 2012
The Kv1.3/Dlg1/Lck complex is part of the membrane pathway utilized by cyclic AMP to regulate T-cell function.
Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.
GeneRIF
Laufer et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2012
Data show that activation of both tuned and untuned CD4 single-positive (SP) thymocytes is Lck-dependent.
More papers using Lck antibodies
The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion.
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Klefstrom Juha, In PLoS ONE, 2004
... Lck-Bax38/1 are mice that harbor two independent transgenic Bax constructs as previously ...
The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling
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Spits Hergen et al., In The Journal of Experimental Medicine, 2002
... Lck-Cre transgenic mice (provided by Merck; ...
An essential role for c-FLIP in the efficient development of mature T lymphocytes
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He You-Wen et al., In The Journal of Experimental Medicine, 2001
... mice were bred with Lck-cre transgenic mice (The Jackson Laboratory; ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT Method.
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Bishai William, In PLoS Pathogens, 2000
... (T202/Y204), p38 (T180/Y182) and CREB (S133), as well as an antibody recognizing phosphorylated Y505 on Lck, were from Cell Signaling Technology (Beverly, MA), Santa ...
The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures
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Reynolds C Hugh et al., In Molecular Neurodegeneration, 1994
... Lck protein was purified using a cobalt containing matrix (Talon, Clontech, Palo Alto, CA, USA) ...
Collagen induces normal signal transduction in platelets deficient in CD36 (platelet glycoprotein IV)
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Takayama Hiroshi et al., In The Journal of Experimental Medicine, 1993
... IgG specific to Fyn (FYN3), Hck (N-30), and PLCγ2 (C19) and affinity-purified goat IgG to Lck (2102) were purchased from Santa Cruz Biotechnology Inc. ...
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