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Fanconi anemia, complementation group E

LCE, FANCE, ELOVL6, long chain fatty acid elongase
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, FANCC, CAN, FAA, FANCG
Papers on LCE
Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.
Ling et al., Copenhagen, Denmark. In Diabetologia, Feb 2016
The most strongly upregulated genes were ELOVL6, FADS2 and NNAT; in contrast, INSR, IRS2 and the SLC27A2 fatty acid transporter showed decreased expression after HFO.
Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.
Vidal-Puig et al., Cambridge, United Kingdom. In Cell Rep, Jan 2016
In this study, we demonstrate that the enzyme Elongation of Very Long Chain fatty acids 6 (Elovl6) is necessary for the thermogenic action of BAT.
Effect of standardized fruit extract of Luffa cylindrica on oxidative stress markers in hydrogen peroxide induced cataract.
Saraf et al., Lucknow, India. In Indian J Pharmacol, Nov 2015
OBJECTIVE: The ability of Luffa cylindrica Roem fruit extract (LCE) to modulate biochemical parameters was investigated by in vitro studies for its role in hydrogen peroxide induced cataract on isolated goat lenses which were incubated for 72 h at 37°C.
Association of the late cornified envelope-3 genes with psoriasis and psoriatic arthritis: a systematic review.
Zhang et al., Hefei, China. In J Genet Genomics, Mar 2015
Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop (LCE) gene cluster, especially the cluster 3 (LCE3) genes.
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model.
Shimano et al., Tsukuba, Japan. In Sci Rep, 2014
Elongation of very long chain fatty acids (ELOVL) family member 6 (Elovl6) is a microsomal enzyme that regulates the elongation of C12-16 saturated and monounsaturated fatty acids (FAs).
Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.
Vidal-Puig et al., Málaga, Spain. In Sci Rep, 2014
The relative composition of these fatty acids (FA) is influenced by the desaturases, SCD1-4 and the elongase, ELOVL6.
Novel qualitative aspects of tissue fatty acids related to metabolic regulation: lessons from Elovl6 knockout.
Shimano, Tsukuba, Japan. In Prog Lipid Res, 2012
As a target gene of SREBP-1 that controls lipogenesis we identified a unique enzyme, Elovl6, which is responsible for the final step in endogenous saturated fatty acid synthesis, thereby controlling tissue fatty acid composition.
Update on the epidermal differentiation complex.
Simon et al., Toulouse, France. In Front Biosci, 2011
Apart from those for involucrin and loricrin, most of the genes are organized in four families: the genes encoding EF-hand calcium-binding proteins of the S100A family, the genes encoding the small proline rich proteins (SPRRs) and the late cornified envelope (LCE) proteins, two families of cornified cell envelope components, and the genes encoding the S100-fused type proteins (SFTPs).
Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Shimano et al., Tsukuba, Japan. In Arterioscler Thromb Vasc Biol, 2011
Elovl6 in macrophages may contribute to foam cell formation and progression of atherosclerosis.
Increased elongase 6 and Δ9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis.
Seegmiller et al., Nashville, United States. In Lipids, 2011
study showed cystic fibrosis cells exhibit increased metabolism along metabolic pathways leading to n-7 and n-9 fatty acids compared with wild-type cells; changes are accompanied by increased expression of Delta5, Delta6 and Delta9 desaturases and elongases 5 and 6
The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.
Tessier et al., Dijon, France. In Biochim Biophys Acta, 2011
Results show that delta-6 desaturase as well as elongase-6 expressions were upregulated in 3-month-old Zucker fatty rats as compared to lean littermates.
Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.
Olson et al., East Lansing, United States. In Am J Physiol Endocrinol Metab, 2011
Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering beta-cells more susceptible to saturated FA-induced ER stress and apoptosis.
ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
Soriguer et al., Málaga, Spain. In Plos One, 2010
Genetic variations in the ELOVL6 gene were associated with insulin sensitivity in this population-based study.
The genetics of psoriatic arthritis: lessons from genome-wide association studies.
Barton et al., Manchester, United Kingdom. In Discov Med, 2010
One study has suggested that late cornified envelope (LCE) gene polymorphisms are associated with psoriasis but not PsA.
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.
Jacobsson et al., Toulouse, France. In Prog Lipid Res, 2010
More recently, several transgenic mouse models lacking either an elongase (Elovl3(-/-), Elovl4(-/-), Elovl5(-/-), Elovl6(-/-)) or a desaturase (Scd-1(-/-), Scd-2(-/-), Fads2(-/-)) have been developed and the second part of this review focuses on the insights gained from studies with these mice, as well as from investigations on cell cultures.
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21.
Liu et al., Hefei, China. In Nat Genet, 2009
In addition to the strong replication for two known susceptibility loci MHC (rs1265181, P = 1.93 x 10(-208), OR = 22.62) and IL12B (rs3213094, P(combined) = 2.58 x 10(-26), OR = 0.78), we identified a new susceptibility locus within the LCE gene cluster on 1q21 (rs4085613, P(combined) = 6.69 x 10(-30), OR = 0.76).
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.
Estivill et al., Barcelona, Spain. In Nat Genet, 2009
In a genome-wide search for copy number variants (CNV) using a sample pooling approach, we have identified a deletion comprising LCE3B and LCE3C, members of the late cornified envelope (LCE) gene cluster.
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Yamada et al., Tsukuba, Japan. In Nat Med, 2007
Mice deficient for Elovl6, the gene encoding the elongase that catalyzes the conversion of palmitate to stearate, were generated and shown to become obese and develop hepatosteatosis when fed a high-fat diet or mated to leptin-deficient ob/ob mice.
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.
Auerbach et al., New York City, United States. In Nat Genet, 2005
Seven Fanconi anemia-associated proteins (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG and FANCL) form a nuclear Fanconi anemia core complex that activates the monoubiquitination of FANCD2, targeting FANCD2 to BRCA1-containing nuclear foci.
Fast liquid-crystal elastomer swims into the dark.
Shelley et al., Kent, United States. In Nat Mater, 2004
We demonstrate here that by dissolving-rather than covalently bonding-azo dyes into an LCE sample, its mechanical deformation in response to non-uniform illumination by visible light becomes very large (more than 60 degrees bending) and is more than two orders of magnitude faster than previously reported.
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