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Clathrin, light chain B

LCB, CLTB
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LCa, ACID, CAN, HAD, fibrillin-1
Papers on LCB
Cranberries (Oxycoccus quadripetalus) inhibit pro-inflammatory cytokine and chemokine expression in 3T3-L1 adipocytes.
New
Olejnik et al., Poznań, Poland. In Food Chem, May 2016
Here we studied the effects of lyophilized cranberries (LCB) on the secretion and expression of PAI-1, IL-6, MCP-1 and leptin in mature 3T3-L1 adipocytes under baseline conditions and excessive inflammatory response elicitation by stimulation with H2O2.
High Orientation of Long chain branched Poly (lactic acid) with Enhanced Blood Compatibility and Bionic Structure.
New
Martyn et al., Chengdu, China. In J Biomed Mater Res A, Feb 2016
In order to enhance the melt strength and thus obtain high orientation degree, long chain branched PLA (LCB-PLA) was prepared at first through a two-step ring-opening reaction during processing.
Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1.
New
Biondi et al., Frankfurt am Main, Germany. In Biochim Biophys Acta, Jan 2016
Pkh phosphorylates the activation loop of Ypks, Tpks, Sch9 and also phosphorylates the eisosome components Lsp1 and Pil1, which play fundamental roles upstream of diverse signaling pathways, including the cell wall integrity and sphingosine/long-chain base (LCB) signaling pathways.
Substrate Specificity, Kinetic Properties and Inhibition by Fumonisin B1 of Ceramide Synthase Isoforms from Arabidopsis.
New
Markham et al., Lincoln, United States. In Biochem J, Jan 2016
In Arabidopsis, the varied chemical composition of ceramide is determined by the specificity of three different isoforms of ceramide synthase, denoted LOH1, 2 and 3, for a range of long-chain base (LCB) and acyl-CoA substrates.
Sea cucumber cerebrosides and long-chain bases from Acaudina molpadioides protect against high fat diet-induced metabolic disorders in mice.
New
Wang et al., Qingdao, China. In Food Funct, Dec 2015
In the present study, sea cucumber cerebrosides (SCC) and the main structural units, long-chain bases (LCB), were prepared from Acaudina molpadioides and then administered to high fat (HF) diet-induced obese C57BL/6J mice at a diet supplement dosage of 0.025% for 5 weeks to evaluate their effects on obesity-related metabolic disorders.
Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration.
New
Nishina et al., Stony Brook, United States. In Proc Natl Acad Sci U S A, Nov 2015
Sphingolipids typically have an 18-carbon (C18) sphingoid long chain base (LCB) backbone.
Genomic Resources of Three Pulsatilla Species Reveal Evolutionary Hotspots, Species-Specific Sites and Variable Plastid Structure in the Family Ranunculaceae.
Sawicki et al., Olsztyn, Poland. In Int J Mol Sci, 2014
Four junctions between single copy regions and inverted repeats and junctions between the identified locally-collinear blocks (LCB) were confirmed by Sanger sequencing.
Quantitative Profiling of Long-Chain Bases by Mass Tagging and Parallel Reaction Monitoring.
Fabregat et al., Odense, Denmark. In Plos One, 2014
To understand how regulation of sphingolipid metabolism and levels of individual LCB species impinge upon physiological and pathophysiological processes requires sensitive and specific assays for monitoring these molecules.
Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
GeneRIF
Harrison et al., Boston, United States. In Embo J, 2010
Structure of clathrin coat with bound Hsc70 and auxilin.
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.
GeneRIF
Dias-Neto et al., São Paulo, Brazil. In J Neural Transm, 2009
This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.
Regulation of ceramide biosynthesis by TOR complex 2.
Impact
Powers et al., Davis, United States. In Cell Metab, 2008
Because Ypk2 is activated independently by LCBs, the direct precursors to ceramides, our data suggest a model wherein TORC2 signaling is coupled with LCB levels to control Ypk2 activity and, ultimately, regulate ceramide formation.
Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.
Review
Igarashi et al., Sapporo, Japan. In Prog Lipid Res, 2007
The addition of phosphate groups to LCB/Sph and Cer generates LCBP/S1P and C1P, respectively.
Clathrin light chain b is capable of affecting potently a major protein phosphatase from microtubules (MT-PP1).
GeneRIF
Munakata et al., Sendai, Japan. In Febs Lett, 2006
CLTLB purified from bovine brain postmicrotubule supernatant and identified by mass spectrometry potently inhibited a catalytic activity of a major protein phosphatase (PP) that was copurified with microtubules and recognized by antiPP1 antibodies
Differential control of clathrin subunit dynamics measured with EW-FRAP microscopy.
GeneRIF
Klingauf et al., Göttingen, Germany. In Traffic, 2005
Data suggest that clathrin heavy chains bound to light chains (LC) a and b contribute to pit formation, but the affinity of LCa-free HC in pits is reduced, and the Ca(2+)- and ATP-mediated control of clathrin function is lost.
Clathrin light and heavy chain interface: alpha-helix binding superhelix loops via critical tryptophans.
GeneRIF
Brodsky et al., San Francisco, United States. In Embo J, 2002
Based on circular dichroism data, mapping and mutagenesis, bovine LCa and LCb were represented as alpha-helices, aligned along the heavy chain. A structural model of the interaction was generated with new implications for LC control of clathrin assembly.
Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis.
Impact
Hill et al., Stanford, United States. In Cell, 1990
Uncoating of clathrin-coated vesicles is mediated by the heat shock cognate protein, hsc70, and requires clathrin light chains (LCa and LCb) and ATP hydrolysis.
[Lyme borreliosis: underdiagnosed?--overtreated?].
Review
Peuckert, Freiburg, Germany. In Monatsschr Kinderheilkd, 1990
B. burdorferi is also responsible for an early skin lesion, Borrelia lymphozytom [Lymphadenosis cutis benigna (LCB)], and for a late one, Acrodermatitis chronica atrophicans (ACA), both seen primarily in Europe.
Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs.
Impact
Brosius et al., In Science, 1987
The clathrin light chains fall into two major classes, LCA and LCB.
Localization of clathrin light-chain sequences mediating heavy-chain binding and coated vesicle diversity.
Impact
Parham et al., In Nature, 1987
This molecular variability derives from tissue-specific patterns of expression of LCa and LCb genes.
Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments.
Impact
Parham et al., In Nature, 1987
Light chains LCa and LCb are homologous proteins encoded by different genes.
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