Histiocytic and Nonhistiocytic Glomerular Lesions: Foam Cells and Their Mimickers.
Rochester, United States. In Am J Kidney Dis, Dec 2015
We have observed this histiocytic/foamy glomerular change on the kidney biopsy specimen in 5 different disease entities: crystal-storing histiocytosis, histiocytic glomerulopathy associated with macrophage-activating syndrome, thrombotic microangiopathy, lecithin-cholesterol acyltransferase deficiency, and lipoprotein glomerulopathy.
Implications of reverse cholesterol transport: recent studies.
Louisville, United States. In Clin Chim Acta, Feb 2015
CONCLUSIONS: Mutation studies of ABCA1, LCAT and SR-B1 genes in humans showed expected variations in HDLC but little association with ASCVD and there was no significant association between HDLC and ASCVD in Mendelian randomization studies.
Paraoxonase 1 and HDL maturation.
Vallejo, United States. In Clin Chim Acta, Feb 2015
PON1 activation and flux across HDL particles are blocked by CETP and LCAT inhibitors.
HDL biogenesis, remodeling, and catabolism.
Boston, United States. In Handb Exp Pharmacol, 2014
The biogenesis of HDL initially requires functional interaction of apoA-I with the ATP-binding cassette transporter A1 (ABCA1) and subsequently interactions of the lipidated apoA-I forms with lecithin/cholesterol acyltransferase (LCAT).
High-density lipoprotein metabolism, composition, function, and deficiency.
Boston, United States. In Curr Opin Lipidol, 2014
PURPOSE OF REVIEW: To examine the recent advances in our knowledge of HDL metabolism, composition, function, and coronary heart disease (CHD), as well as marked HDL deficiency states because of mutations in the apolipoprotein (apo) A-I, ATP-binding cassette transfer protein A1 and lecithin cholesterol acyltransferase (LCAT) gene loci.
HDL genetic defects.
London, United Kingdom. In Curr Pharm Des, 2013
Tangier disease and Fish Eye disease are caused by mutations in the ATP binding cassette A1 (ABCA1), a transport protein, and lecithin cholesterol acyl transferase (LCAT), an enzyme, involved in the esterification of cholesterol, respectively.
The role of HDL and its modulators in the development of diabetes.
In Curr Opin Lipidol, 2012
Studies indicate the direct effects of HDL and its major modulators, ATP-binding cassette transporter A1 (ABCA1), apolipoprotein A-I (ApoA-I), and lecithin cholesterol acyltransferase (LCAT) on the development of type 2 diabetes mellitus (T2D).
Cloning and sequencing of human cholesteryl ester transfer protein cDNA.
In Nature, 1987
Catalysed steps of this pathway are believed to include an efflux from peripheral cells, which generates a diffusion gradient between these membranes and extracellular fluid; esterification of this cholesterol by lecithin-cholesterol acyltransferase (LCAT) (phosphatidylcholine-sterol acyltransferase) acting on species of high-density lipoproteins; transfer of the cholesteryl esters formed (largely to low- and very low-density lipoproteins) (LDL and VLDL) by a cholesteryl ester transfer protein (CETP); and removal of these lipoproteins, together with their cholesteryl ester content, by the liver through receptor-mediated and nonspecific endocytosis.